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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
ALPL Regulates Pro-Angiogenic Capacity of Mesenchymal Stem Cells through ATP-P2X7 Axis Controlled Exosomes Secretion
[Journal of Nanobiotechnology] Exosomes derived from normal and hypophosphatasia human bone marrow MSCs were isolated and identified by ultracentrifugation, transmission electron microscopy, and nanoparticle size measurement.
HWJMSC-EVs Promote Cartilage Regeneration and Repair via the ITGB1/TGF-β/Smad2/3 Axis Mediated by Microfractures
[Journal of Nanobiotechnology] Researchers verify whether MSC-derived extracellular vesicles (MSC-EVs) promoted cartilage damage repair mediated by microfractures and to explore the repair mechanisms.
Bioengineered MSCCxcr2 Transdifferentiated Keratinocyte-Like Cell-Derived Organoid Potentiates Skin Regeneration Through ERK1/2 and STAT3 Signaling in Diabetic Wound
[Cellular And Molecular Life Sciences] 3D skin organoids generated using MSCCxcr2-derived keratinocyte-like cells upon grafting in a relatively avascular and non-healing wounds of type 2 diabetic transgenic mice resulted in a significant enhancement in the rate of wound closure by increased epithelialization and endothelialization.
Mitochondrial Ca2+ Signaling Is a Hallmark of Specific Adipose Tissue-Cancer Crosstalk
[Scientific Reports] The authors showed that conditioned media derived from adipose tissue cultures enriched in precursor cells impinge on mitochondrial Ca2+ homeostasis of target cells.
Comprehensive Assessment of Goat Adipose Tissue-Derived Mesenchymal Stem Cells Cultured in Different Media
[Scientific Reports] Scientists assessed the effects of four commonly used culture media on goat adipose tissue-derived MSC culture characteristics, stem cell-specific immunophenotype, and differentiation.
Mesenchymal Stem Cell Based Therapies for Uveitis: A Systematic Review of Preclinical Studies
[Eye] Researchers analysed and critically appraised all preclinical studies using cell therapy or cell derived extracellular vesicles for uveitis, and provided insight into mechanisms regulating ocular inflammation.
Cell Membrane Vesicles Derived From hBMSCs and hUVECs Enhance Bone Regeneration
[Scientific Reports] Investigators successfully prepared cell membrane vesicles from BMSCs and endothelial cells. The results showed that BMSC-derived cell membrane vesicles possessed membrane receptors involved in juxtacrine signaling and growth factors derived from their parental cells.
Efficacy and Safety of Mesenchymal Stem Cell Therapy for Ovarian Aging in a Mouse Model
[Stem Cell Research & Therapy] Two common sources of MSCs, umbilical cord-derived MSCs and adipose tissue-derived MSCs, were orthotopically transplanted into a mouse model of ovarian aging to evaluate their therapeutic effects.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7
[Molecular Neurobiology] Researchers explored the role of miR-140-5p delivered by MSC-extracellular vesicles in mitigating brain damage following subarachnoid hemorrhage (SAH). Serum from SAH patients and healthy individuals was analyzed for miR-140-5p and cAMP levels.
Exosomes From Adipose-Derived Mesenchymal Stem Cell Improve Diabetic Wound Healing and Inhibit Fibrosis via miR-128-1-5p/TGF-β1/Smad Axis
[Molecular And Cellular Endocrinology] In vitro, adipose stem cell-derived exosomes significantly enhanced proliferation and migration of rat skin fibroblasts while reducing the expression of TGF-β1 and α-SMA.
Regulatory T Cell-Derived Exosome Mediated Macrophages Polarization for Osteogenic Differentiation in Fracture Repair
[Journal Of Controlled Release] Investigators constructed regulatory T cell-derived exosomes for the treatment of fracture. The obtained exosomes displayed a spheroid shape with a hydrated particle size of approximately 130 nm.
Charles River Announces Rare Disease Gene Therapy Collaboration with Axovia Therapeutics
[Charles River Laboratories International, Inc. (BusinessWire, Inc.)] Charles River Laboratories International, Inc. announced a plasmid DNA contract development and manufacturing organization collaboration with Axovia Therapeutics Ltd. Charles River will manufacture High Quality gene of interest plasmid to support the development of Axovia’s gene therapies for ciliopathies, including Bardet-Biedl Syndrome, a condition with limited treatment options and no cure.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
