Volume 6.39 | Oct 14

Mesenchymal Cell News 6.39 October 14, 2014
Mesenchymal Cell News
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New Technique Allows Scientists to Identify Populations of Rare Stem Cells in Bone Marrow
Researchers identified three physical characteristics of mesenchymal stem cells (MSCs) that can distinguish them from other immature cells found in the bone marrow. Based on this information, they plan to create devices that could rapidly isolate MSCs, making it easier to generate enough stem cells to treat patients. [Press release from Massachusetts Institute of Technology discussing online prepublication in Proceedings of the National Academy of Sciences USA ] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Conversion of Th17 into IL-17Aneg Regulatory T Cells: A Novel Mechanism in Prolonged Allograft Survival Promoted by Mesenchymal Stem Cell-Supported Minimized Immunosuppressive Therapy
The authors found that when mesenchymal stem cells (MSCs) were used to induce long-term acceptance of allogeneic heart grafts in mice, the induction of regulatory T cells was preceded by development of a CD11bhiGr1int myeloid-derived immunosuppressive cell-mediated Th17 response. [J Immunol] Abstract

Non-Invasive Characterization of the Adipogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells by HS-SPME/GC-MS
Using optimized procedures, researchers discovered that seven fatty acid methyl esters were only detected in adipogenic differentiated mesenchymal stromal cells and not in the mesenchymal stromal cells before differentiation. [Sci Rep] Full Article

Intermittent PTHrP(1-34) Exposure Augments Chondrogenesis and Reduces Hypertrophy of Mesenchymal Stromal Cells
Scientists evaluated whether intermittent supplementation of parathyroid hormone-related protein (PTHrP), as opposed to constant treatment, can beneficially influence mesenchymal stromal cells chondrogenesis and explored molecular mechanisms below catabolic and anabolic responses. [Stem Cells Dev] Full Article

Paracrine-Mediated Neuroprotection and Neuritogenesis of Axotomized Retinal Ganglion Cells by Human Dental Pulp Stem Cells: Comparison with Human Bone Marrow and Adipose-Derived Mesenchymal Stem Cells
Researchers investigated and compared the neurotrophic activity of human dental pulp stem cells, human bone marrow-derived mesenchymal stem cells and human adipose-derived stem cells on axotomized adult rat retinal ganglion cells (RGC) in vitro in order to evaluate their therapeutic potential for neurodegenerative conditions of RGC. [PLoS One] Full Article

Testing Stem Cell Therapy in a Rat Model of Inflammatory Bowel Disease: Role of Bone Marrow Stem Cells and Stem Cell Factor in Mucosal Regeneration
Scientists explored a role of bone marrow mesenchymal stromal cells and soluble stem cell factor in gastrointestinal mucosa regeneration in a rat model of inflammatory bowel diseases. [PLoS One] Full Article

Effects of Different Mesenchymal Stromal Cell Sources and Delivery Routes in Experimental Emphysema
Investigators assessed whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route.
[Respir Res]
Full Article

Comparison of Therapeutic Characteristics of Islet Cell Transplantation Simultaneous with Pancreatic Mesenchymal Stem Cell Transplantation in Rats with Type 1 Diabetes Mellitus
Researchers investigated the effect of pancreatic mesenchymal stem cell transplantation simultaneous with islet cell transplantation on islet liveliness and thus on the treatment of diabetes in type 1 diabetic rats.
[Stem Cell Rev]

Curcumin-Induced Heme Oxygenase-1 Expression Prevents H2O2-Induced Cell Death in Wild Type and Heme Oxygenase-2 Knockout Adipose-Derived Mesenchymal Stem Cells
In order to analyze potential modulatory effects of the heme oxygenase (HO)-system on adipose-derived mesenchymal stem cell (ASC) survival, wildtype and HO-2 knockout ASCs were pre-treated with HO-activity modulators, or downstream effector molecules biliverdin, bilirubin, and CO before co-exposure of ASCs to a toxic dose of H2O2. [Int J Mol Sci] Abstract | Download Full Article

Myocardin and Pdx-1 Synergistically Induce hMSCs to Differentiate into Insulin Secreting Cells
Researchers investigated a new method to induce the differentiation of human mesenchymal stem cells (hMSCs) into insulin secretion cells and explored its molecular mechanisms. They investigated in vitro differentiation of hMSCs by overexpression of myocardin and pdx-1. [Biochem Biophys Res Commun] Abstract

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Homing of Mesenchymal Stem Cells: Mechanistic or Stochastic? Implications for Targeted Delivery in Arthritis
The authors discuss current knowledge of the mechanism of mesenchymal stem cell (MSC) homing to injured/inflamed tissue and its implications for targeted MSC-based therapy in arthritis. [Rheumatology] Abstract

A Review of Therapeutic Effects of Mesenchymal Stem Cell Secretions and Induction of Secretory Modification by Different Culture Methods
This review summarizes the up- and down-regulation of mesenchymal stem cell anti-inflammatory, immune modulating, anti-tumor, and regenerative secretions resulting from different stimuli. [J Transl Med]
| Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Global Controls in Stem Cells
NIH Common Fund Announces 2014 High-Risk, High-Reward Research Awardees
Eighty-five grants have been awarded to scientists proposing highly innovative approaches to major contemporary challenges in biomedical research, under the High Risk-High Reward program supported by the National Institutes of Health (NIH)’s Common Fund. [National Institutes of Health] Press Release

Henry Ford Celebrates First Double-Cord Stem Cell Transplant
Doctors at Henry Ford Hospital are celebrating the success of the system’s first double-cord stem cell transplant, a promising treatment for African Americans and other minorities affected by disparities in life-saving transplant options. [Henry Ford Hospital] Press Release

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NEW World Stem Cell Summit 2014
December 3-5, 2014
San Antonio, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Research Associate Position – Skeletal Research Center (Case Western Reserve University)

PhD Studentship – Biophysics and Mechanics of Stem Cells (Queen Mary University of London)

Postdoctoral Position – Epigenetics in Aging, Osteoporosis and Stem Cells (Aachen University Medical School)

Postdoctoral Fellow – Chondrocyte Differentiation and Its Role in Osteoarthritis (NYU Langone Medical Center)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellowship – Epigenetic Regulation of Cell Fate and Metabolism (University Medical Center Freiburg)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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