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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
MSC Promotes the Secretion of Exosomal lncRNA KLF3-AS1 to Regulate Sphk1 through YY1-Musashi-1 Axis and Improve Cerebral Ischemia–Reperfusion Injury
[Molecular Neurobiology] The oxygen–glucose deprivation/reoxygenation and middle cerebral artery occlusion rat model were generated. MSCs were isolated and characterized by flow cytometry and histochemical staining, and MSC exosomes were purified and characterized by transmission electron microscopy, flow cytometry, and Western blot.
A Novel miR-466l-3p/FGF23 Axis Promotes Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
[Bone] Scientists investigated the potential role of miR-466 l-3p in osteoporosis (OP). The expression levels of miR-466 l-3p and fibroblast growth factor 23 (FGF23) were quantified in the trabeculae of the femoral neck of 40 individuals with or without OP using qRT-PCR.
Vasoactive Intestinal Peptide Exerts an Osteoinductive Effect in Human Mesenchymal Stem Cells
[BioFactors] Researchers characterized the influence of the neuropeptide vasoactive intestinal peptide on the differentiation process of human MSCs into osteoblasts and on their anabolic function.
Synergistic Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicle and miR-137 Alleviates Autism-Like Behaviors by Modulating the NF-κB Pathway
[Journal of Translational Medicine] The authors explored the effectiveness of MSC-derived extracellular vesicles loaded with miR-137 in enhancing autism-like behaviors and mitigating neuroinflammation.
Melatonin and Mesenchymal Stem Cells Co-Administration Alleviates Chronic Obstructive Pulmonary Disease via Modulation of Angiogenesis at the Vascular-Alveolar Unit
[Pflugers Archiv-European Journal Of Physiology] The COPD model was established using cigarette smoking and lipopolysaccharide. The COPD rats were divided into four groups: COPD group, Melatonin-treated group, MSC-treated group, and combined treated group, Melatonin–MSCs.
Mesenchymal Stem Cell Secretome for Regenerative Medicine: Where Do We Stand?
[Journal of Advanced Research] Investigators discuss the potential benefits of MSC-derived secretome in regenerative medicine with particular focus on respiratory, hepatic, and neurological diseases.
NSF Awards $630,000 to Study Teeth of Non-Human Primates
[University of Arkansas (EurekAlert)] The National Science Foundation (NSF) awarded $630,444 to Kathleen Paul, an assistant professor of anthropology at the University of Arkansas, to provide a comprehensive outline of dental genetic architecture for two primate species of tamarins and macaques.
Bone Mesenchymal Stem Cells Improve Cholestatic Liver Fibrosis by Targeting ULK1 to Regulate Autophagy through PI3K/AKT/mTOR Pathway
[Stem Cells Translational Medicine] Scientists investigated the therapeutic effects and underlying mechanisms of bone MSCs transplantation in mouse models of bile duct ligation-induced cholestatic liver fibrosis.
Role of Umbilical Cord Mesenchymal Stromal Cells in Skin Rejuvenation
[npj Regenerative Medicine] Investigators summarize the characteristics of skin aging and the mechanism of umbilical cord-derived MSCs (UC-MSCs) in skin rejuvenation reported in recent years in order to provide a reference for further research of UC-MSCs to delay skin aging.
Dexamethasone-Integrated Mesenchymal Stem Cells for Systemic Lupus Erythematosus Treatment via Multiple Immunomodulatory Mechanisms
[ACS Nano] Scientists presented a promising strategy based on dexamethasone liposome-integrated MSCs for treating systemic lupus erythematosus via multiple immunomodulatory pathways.
Vascular Architecture Regulates Mesenchymal Stromal Cell Heterogeneity via P53-PDGF Signaling in the Mouse Incisor
[Cell Stem Cell] Using adult mouse incisors as a model, scientists uncovered the role of Trp53 in regulating vascular composition through THBS2 to maintain mesenchymal tissue homeostasis.
YTHDF2-Mediated m6A Methylation Inhibition by miR27a as a Protective Mechanism against Hormonal Osteonecrosis in BMSCs
[BMC Musculoskeletal Disorders] Researchers compared miR27a, YTHDF2, and total m6A mRNA levels in steroid-induced necrosis of the femoral head-affected and control bone marrow MSCs. CCK-8 and TUNEL assays were used to assess BMSC proliferation and apoptosis.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
