| Mesenchymal Cell News 10.43 October 30, 2018 | |
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TOP STORYMelatonin-treated chronic kidney disease-derived MSCs (CKD-mMSCs) survived longer, with increased secretion of angiogenic cytokines in ischemic disease engraftment sites. CKD-mMSCs were more susceptible to H2O2-induced senescence than normal-mMSCs, and melatonin administration protected CKD-mMSCs from excessive senescence by up-regulating PrPC and enhancing mitochondrial function. [J Pineal Res] Abstract |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROPanobinostat effectively inhibited all malignant glioma cells, enhancing the expression of DRs, but not in human adipose tissue-derived MSCs (hAT-MSCs). Combined treatment with hAT-MSC expressing the secreted form of the tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) and panobinostat significantly suppressed cell viability and enhanced apoptosis. [Cancer Lett] Abstract Osteogenesis-associated long noncoding RNA (lncRNA-OG) interacted with heterogeneous nuclear ribonucleoprotein K (hnRNPK) protein to regulate bone morphogenetic protein signaling pathway activation. hnRNPK positively regulated lncRNA-OG transcriptional activity by promoting H3K27 acetylation of the lncRNA-OG promoter. [Stem Cells] Abstract Scientists demonstrated that mDia1, a downstream effector of RhoA, exerted a crucial function in Activin B-induced bone marrow-derived MSC (BMSC) migration by promoting membrane ruffling, microtubule morphology and adhesion signaling dynamics. They showed that Activin B did not change Rac1 activity but increased Cdc42 activity in BMSCs. [Stem Cells] Abstract CD90high glioma-associated MSCs (gbMSCs) significantly drove glioma progression mainly by increasing proliferation, migration and adhesion, where as CD90low gbMSCs contributed to glioma progression chiefly through the transition to pericytes and stimulation of vascular formation via vascular endothelial cells. [Cell Death Dis] Full Article The authors showed that bone marrow MSCs (BMSC) provided resistance to acute myeloid leukaemia (AML) cells against BH3-mimetics, cytarabine and daunorubicin, but this was not mediated by Bcl-2 and/or Bcl-XL as previously thought. [Sci Rep] Full Article Researchers implemented regression modeling to identify eight MSC-secreted proteins that correlated strongly with improved rescue from radiation damage, including hematopoietic recovery, in a murine model of hematopoietic failure. They then predicted recovery potential of MSC populations that were culture expanded on substrata of varying mechanical stiffness. [Stem Cell Res Ther] Full Article | Press Release IN VIVOInvestigators attempted to evaluate oxidative stress and supraspinal neuro-inflammation in rat brain after sciatic nerve injury. The expression of a microglial marker and reactive oxygen species was lower in dental pulp stem cells (DPSCs) and higher in differentiated neuronal cells from DPSCs (DF-DPSCs). In contrast, the expression of an astroglial marker was higher in DPSCs and lower in DF-DPSCs at two weeks. [Sci Rep] Full Article miR-9 modified BMSCs (pri-miR-9-BMSCs) induced angiogenesis in SAP rats and repaired damaged vascular endothelial cells (VECs) in vitro, promoting angiogenesis. Pri-miR-9-BMSCs released miR-9 into VECs or injured pancreatic tissue, targeting the VE-cadherin gene and promoting PI3K/AKT signaling to treat SAP, whereas antagonizing miR-9 in BMSCs did not alleviate or aggravated SAP. [Stem Cell Res Ther] Full Article Sorafenib, in combination with MSCs, strongly inhibited tumor growth in the xenograft model. The combination therapy significantly inhibited hepatocellular carcinoma cell proliferation, decreased tumor angiogenesis, and induced apoptosis and maintained antitumor-associated anti-inflammatory effects of MSCs. [J Cell Physiol] Abstract Researchers investigated the effect of heme oxygenase-1 (HO-1)-modified bone-marrow-derived MSCs (MSCs-HO-1) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and its underlying mechanisms. The ALI rat model was established by successive LPS inhalations following injection with MSCs-HO-1. [J Cell Physiol] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. |
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REVIEWSThe Mechanisms and Potential of Stem Cell Therapy for Penile Fibrosis In preclinical studies, MSCs have proven to be the most effective and readily available type of stem cells for therapeutic use. Many studies using stem cells have been applied exclusively to corpora cavernosa fibrosis owing to its well-established disease models. A plethora of preclinical data suggest the benefit of stem cells for use in penile fibrosis. [Nat Rev Urol] Abstract Pulp Stem Cell-Mediated Functional Pulp Regeneration The authors summarize recent breakthroughs in pulp stem cell-mediated pulp regeneration, emphasizing the crucial achievement of neurovascularization. This functional pulp regeneration represents an innovative and promising approach for future regenerative endodontics. [J Dent Res] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. |
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INDUSTRY NEWSBiological Industries USA, and StemExpress announced a strategic partnership for the non-exclusive worldwide distribution of StemExpress’ human bone marrow-derived MSCs. [Biological Industries USA (Business Wire, Inc.)] Press Release Mesoblast Limited announced it has expanded its partnership with JCR Pharmaceuticals Co. Ltd. in Japan for wound healing in patients with Epidermolysis Bullosa (EB). JCR has received Orphan Designation for the allogeneic MSC product TEMCELL HS Inj in the treatment of EB. [Mesoblast Limited (GlobeNewswire, Inc.)] Press Release SpinalCyte, LLC announced 12-month endpoint data from its Phase I/Phase II clinical trial for treatment of degenerative disc disease. The analysis showed that patients who received intradiscal injections of the HDF product CybroCell™ had sustained improvement in pain relief and increased back mobility after 12 months. [SpinalCyte, LLC] Press Release Scientists Awarded $8 Million to Develop Tissue Regeneration Therapy A new method developed at Cedars-Sinai may revolutionize how severe injuries are treated by harnessing stem cells to regrow tissue damaged by major trauma, such as traffic accidents or war injuries. The new tissue-regeneration technique recently earned three Cedars-Sinai investigators grants from the Department of Defense and National Institutes of Health totaling nearly $8 million. [Cedars-Sinai] Press Release | |
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POLICY NEWSAustralian Academics Fear Political Interference following Vetoed Projects Australian universities and researchers have condemned the actions of a government minister who vetoed projects that had been selected for funding by expert panels. Academics say that the government’s interference has undermined the integrity of the peer-review system and could damage the country’s reputation as a desirable place to do research. [Nature News] Editorial Top Genomics Institute Clears Director of Bullying and Gender Discrimination The Wellcome Sanger Institute dismissed allegations of harassment and misuse of funds, following an independent investigation. [Nature News] Editorial Heart Failure Stem Cell Trial to Be Paused after Calls for Retractions The National Institutes of Health will pause human testing of an experimental stem cell therapy for heart failure while a board charged with overseeing patient safety reviews the taxpayer-funded trial, in light of emerging questions about the scientific foundation for the treatment. [The Washington Post] Editorial
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EVENTSNEW 7th International Stem Cell Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Professor – Stem Cell & Regenerative Medicine (University College London) NEW Faculty Position – Department of Biochemistry & Molecular Biology (Mayo Clinic) PhD Positions/ Early Stage Researcher Positions – EU Horizon 2020 MSCA-ITN Project (Renal Tool Box) Assistant Professor – Department of Stem Cell and Regenerative Biology (Harvard University) Faculty Positions – Biomedical Engineering (Pennsylvania State University) Assistant Professor – Stem Cell and Regenerative Biology (Columbia University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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