Volume 12.24 | Jun 23

Mesenchymal Cell News 12.24 | Jun 23
Mesenchymal Cell News by STEMCELL Technologies
Vol. 12.24 – 23 June, 2020
TOP STORY

Mesenchymal Stem Cells Offer a Drug-Tolerant and Immune-Privileged Niche to Mycobacterium tuberculosis

Investigators report that mesenchymal stem cells (MSCs) sheltered Mybacterium tuberculosis (Mtb) to help tolerate anti-TB drugs. MSCs readily took up Mtb and allowed unabated mycobacterial growth despite having a functional innate pathway of phagosome maturation.
[Nature Communications]

Full Article

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
PUBLICATIONSRanked by the impact factor of the journal

Geriatric Fragility Fractures are Associated with a Human Skeletal Stem Cell Defect

Functional analysis of isolated stem cells revealed that advanced age significantly correlated with reduced osteochondrogenic potential but was not associated with decreased in vitro clonogenicity.
[Aging Cell]

Full Article

Induction of ASC Pyroptosis Requires Gasdermin D or Caspase-1/11-Dependent Mediators and IFNβ from Pyroptotic Macrophages

Scientists found that LPS, flagellin, dsDNA, nigericin, or LPS combined with nigericin could not induce pyroptosis in adipose-tissue-derived mesenchymal stem cells.
[Cell Death & Disease]

Full Article

Berberine Mediates Root Remodeling in an Immature Tooth with Apical Periodontitis by Regulating Stem Cells from Apical Papilla Differentiation

Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity, mineralization ability, and gene expression of osteogenic makers.
[International Journal of Oral Science]

Full Article

TGF-β-Driven Downregulation of the Transcription Factor TCF7L2 affects Wnt/β-Catenin Signaling in PDGFRα+ Fibroblasts

The authors investigated whether damage-induced transforming growth factor β signaling impaired the expression and function of T-cell factor 4, using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors.
[Journal of Cell Science]

Abstract

Fibronectin 1 Activates WNT/β-Catenin Signaling to Induce Osteogenic Differentiation via Integrin β1 Interaction

Researchers report that fibronectin 1 promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts.
[Laboratory investigation]

Abstract

Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells

Investigators report the ability of a scalable hollow fiber bioreactor to effectively maintain ideal mesenchymal stem cell function as a single population while also being able to impart an immunoregulatory effect when cultured in tandem with an inflamed lymphocyte population.
[Scientific Reports]

Full Article

Dose and Duration of Interferon γ Pre-Licensing Interact with Donor Characteristics to Influence the Expression and Function of Indoleamine-2,3-Dioxygenase in Mesenchymal Stromal Cells

Scientists found that across three human MSC donors, MSCs increased their expression of indoleamine-2,3-dioxygenase in response to both increased dose of IFNγ and duration of pre-licensing.
[Journal of the Royal Society interface]

Full Article

Piezo2 Expressed in Proprioceptive Neurons Is Essential for Skeletal Integrity

While loss of Piezo2 in chondrogenic or osteogenic lineages did not lead to human-like skeletal abnormalities, its loss in proprioceptive neurons led to spine malalignment and hip dysplasia.
[Nature Communications]

Full Article

Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo

Scientists demonstrated that MSC-derived factors could stimulate oligodendrogenesis and myelin sheath generation of adult neural stem cells transplanted into different rodent central nervous system regions.
[International Journal of Molecular Sciences]

Full Article

Runx2 Regulates Mouse Tooth Root Development via Activation of WNT Inhibitor Notum

Investigators provided in vivo evidence that Runx2 played a crucial role in tooth root development and in regulating the differentiation of root progenitor cells.
[Journal of Bone and Mineral Research]

Abstract

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REVIEWS

Exosomes: Roles and Therapeutic Potential in Osteoarthritis

The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discuss the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
[Bone Research]

Full Article

INDUSTRY AND POLICY NEWS

Ultragenyx and Kyowa Kirin Announce US FDA Approval of Crysvita® (Burosumab) for the Treatment of Tumor-Induced Osteomalacia (TIO)

Ultragenyx Pharmaceutical, Inc. and Kyowa Kirin Co., Ltd. announced that the FDA has approved Crysvita® for the treatment of fibroblast growth factor 23-related hypophosphatemia in tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors that cannot be curatively resected or localized in adults and pediatric patients two years of age and older.
[Ultragenyx Pharmaceutical, Inc.]

Press Release

Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]

Editorial

Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]

Editorial

FEATURED EVENT

Life Science Innovation Northwest Conference

2020-07-16 – 2020-07-17
Virtual

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JOB OPPORTUNITIES

Senior Scientist – Process Development Lab, Gene and Cell Therapy

Genezen Laboratories – Indianapolis, Indiana, United States

Postdoctoral Fellow – Mesenchymal Neoplasms

Memorial Sloan Kettering Cancer Center – New York, New York, United States

Quality Control Manager – Gene and Cell Therapy

Genezen Laboratories – Indianapolis, Indiana, United States

Postdoctoral Position – Bone Development

KU Leuven – Leuven, Belgium

Postdoctoral Position – Regeneration of Diseased Bone

Radboud umc – Nijmegen, Netherlands

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