Volume 2.06 | Feb 16

Mesenchymal Cell News 2.06, February 16, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Biologists Image Birth of Blood-Forming Stem Cells in Embryo
Biologists have identified the specific region in vertebrates where adult blood stem cells arise during embryonic development. [Press release from the EurekaAlert! discussing the online prepublication in Nature]

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SCIENCE NEWS

Method of the Future Uses Single-Cell Imaging to Identify Gene Interactions
Researchers have developed a novel method of interpreting data from single-cell images to identify genetic interactions within biological networks, offering a glimpse into the future of high-throughput cell imaging analysis. [Press release from EurekaAlert! discussing the online prepublication in Genome Research]

Long-Term Comparisons of Induced Pluripotency Stem Cells and Human Embryonic Stem Cells Conducted to Assess Therapeutic Potential
For the first time, scientists have performed a detailed long-term evaluation and comparison of two different types of pluripotent stem cells: human embryonic stem cells and induced pluripotency stem cells. [Press release from Advanced Cell Technology discussing the online prepublication in Stem Cells]

‘Death’ Proteins Help Stem Cells Develop: Study
Stem cells that can repair and regenerate tissues may need to get their DNA chopped up as a normal part of growing up and turning into specialized cells like muscle cells, Ottawa researchers have found. [Press release from the Canadian Broadcasting Corporation discussing the online prepublication in the Proceedings of the National Academy of Sciences]

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CURRENT PUBLICATIONS

Comparison of Mesenchymal Stem Cells from Bone Marrow and Adipose Tissue for Bone Regeneration in a Critical Size Defect of the Sheep Tibia and the Influence of Platelet-Rich Plasma
Aim of the present study was to compare the osteogenic potential of bone marrow derived mesenchymal stem cells and adipose-tissue derived stem cells (ASC) and to evaluate the influence of platelet-rich plasma on the osteogenic capacity of ASC in a large animal model. [Biomaterials

Chondrogenic Differentiation of Human Adipose-Derived Stem Cells in Polyglycolic Acid Mesh Scaffolds Under Dynamic Culture Conditions
Cells cultured under dynamic conditions in polyglycolic acid scaffolds produced substantially higher glycosaminoglycan and total collagen levels than cells in pellet cultures. [Biomaterials

Protein Kinase C-Delta is Involved in the Inflammatory Effect of IL-6 in Mouse Adipose Cells
The aim of the study was to address the role of protein kinase C-delta on phosphorylation of signal transducer and activator of transcription 3 and activation of inflammatory genes in response to IL-6 in adipose cells. [Diabetologia]

Bone Morphogenetic Protein-3 Promotes Mesenchymal Stem Cell Proliferation Through the Transforming Growth Factor-Beta/Activin Signaling Pathway
Bone Morphogenetic Protein-3 stimulates mesenchymal stem cell (MSC) proliferation via the transforming growth factor-beta (TGF-beta)/activin signaling pathway, thus revealing a novel role for this divergent and poorly understood member of the TGF-beta superfamily in regulating MSC proliferation. [J Cell Physiol]

Animal Serum-Free Expansion and Differentiation of Human Mesenchymal Stromal Cells
Human plasma is a suitable fetal calf serum replacement for the expansion and differentiation of mesenchymal stromal cells, providing a feasible alternative for tissue engineering with good manufacturing practice-compatible protocols. [Cytotherapy]

The Bone Marrow-Derived Human Mesenchymal Stem Cell: Potential Progenitor of the Endometrial Stromal Fibroblast
Mesenchymal stem cells (MSC) can be differentiated down the endometrial stromal fibroblasts (hESF) pathway as evidenced by changes in cell shape and common expression of decidual markers and other genes important in hESF differentiation and function, and these data support that bone marrow-derived MSC may be a source of endometrial stem/progenitor cells. [Biol Reprod]

Characterization of Mesenchymal Stem Cells Isolated from the Rabbit Fetal Liver
The special biological qualities of fetal rabbit liver mesenchymal stem cells endow them as model candidate vehicles/agents for gene/cell therapy strategies applied to a variety of rabbit models of injury, such as osteochondral lesions. [Stem Cells Dev]

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INDUSTRY NEWS

Living Cell Technologies Awarded NZ$4.04 Million New Zealand Government Grant to Advance DIABECELL®
Cell implant company Living Cell Technologies Limited announced that it has been awarded a grant of NZ$4.04 million from the New Zealand government’s Foundation for Research Science & Technology. [Living Cell Technologies Limited Press Release]

Athersys Receives United States Patent Covering Adult Stem Cell Composition & Production
Athersys, Inc. announced that it has been granted U.S. patent 7,659,118 that covers non-embryonic multipotent stem cells, their isolation and expansion, and related pharmaceutical compositions. [Athersys, Inc. Press Release]

£6 Million to be Invested in Further Regenerative Medicine Research and Development
The Technology Strategy Board is to invest a further £6m in regenerative medicine research and development and has invited British companies to bid for funding through two new competitions. [Technology Strategy Board Press Release]

Portland Development Commission Spends $800,000 for Bioscience ‘Wet Labs’
Oregon’s biotech community will soon have access to four wet labs, where early stage companies can test and analyze chemicals and drugs. [Portland Business Journal]

Cartilage Replacement Therapy
Fusion IP has created Progenteq, a new Cardiff University spin-out developing a novel cartilage replacement therapy for use in treating acute knee injuries. [The Engineer]



POLICY NEWS

Expressions of Interest for Membership of the Therapeutic Goods Committee [Therapeutic Goods Administration, Australia]

Medvedev Talks Science in Moscow
Russian science has been getting some bad press recently, what with a recent report on its declining productivity in scientific papers and a letter from expatriate scientists to the Russian president and prime minister warning of the parlous state of basic research. [Russian Academy of Sciences, Russia]

Food and Drug Administration Budget Draws Cries of ‘Not Enough’
A coalition of interests will push for more money, saying chronic underfunding has led to failures at the agency and that society, not just companies, are affected. [Food and Drug Administration, United States]

Delays in Grant Application Submission due to Widespread Winter Storm (NOT-OD-10-061) [National Institutes of Health, United States]

Waivers for Conflicts of Interest for the February 22, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States]

Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001) [National Institutes of Health, United States]

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]

Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Heart, Lung, and Blood Institute, United States]



EVENTS

2010 Bone Marrow Transplant (BMT) Tandem Meetings
February 24-28, 2010
Orlando, United States

36th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

9th Transgenic Technology (TT) Meeting
March 22-24, 2010
Berlin, Germany

4th United Kingdom Mesenchymal Stem Cell Meeting
April 14, 2010
Leeds, United Kingdom

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

World Stem Cells & Regenerative Medicine Congress 2010
May 12-14, 2010
London, United Kingdom

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

5th World Congress on Preventative and Regenerative Medicine
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States



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