Volume 2.07 | Feb 23

Mesenchymal Cell News 2.07, February 23, 2010.
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TOP STORY

Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma
The enhanced clonogenic growth and migratory properties of aldehyde dehydrogenase-positive pancreatic cancer cells suggest that they play a key role in the development of metastatic disease that negatively affects the overall survival of patients with pancreatic adenocarcinoma. [J Natl Cancer Inst]


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SCIENCE NEWS

Stem Cell Capsules to Target Broken Bones
A new way of delivering stem cells could one day lead to a single injection to mend broken or diseased bones and joints, French and Australian scientists say. [Press release from the Australian Broadcasting Corporation discussing the online prepublication in the Proceedings of the National Academy of Sciences USA]

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CURRENT PUBLICATIONS

Active Multilayered Capsules for In Vivo Bone Formation
Herein, the differentiation of stem cells to bone cells using active multilayered capsules is presented. [Proc Natl Acad Sci U S A]

Dose-Dependent Effect of Adipose-Derived Adult Stem Cells on Vertical Bone Regeneration in Rabbit Calvarium
This study suggests that delivery of adipose-derived adult stem cells on anorganic bovine bone (ABB) might effectively increase vertical bone regeneration and implant osseointegration, versus ABB alone. [Biomaterials

The Healing of Critical-Sized Femoral Segmental Bone Defects in Rabbits Using Baculovirus-Engineered Mesenchymal Stem Cells
To explore whether bone marrow-derived mesenchymal stem cells (BMSC) engineered by baculovirus (an emerging gene delivery vector) can heal large bone defects, New Zealand White (NZW) rabbit BMSCs were transduced with the BMP2-expressing baculovirus or VEGF-expressing baculovirus, and co-implanted into critical-sized (10 mm) femoral segmental defects in NZW rabbits. [Biomaterials]

GD2 Expression is Closely Associated with Neuronal Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
Researcher data demonstrates that GD2 ganglioside expression is associated with regulation of basic helix-loop-helix factors and identify neurogenic-capable umbilical cord blood-derived mesenchymal stem cells (MSC), providing new insights into the potential clinical applications of MSC-based therapy. [ Cell Mol Life Sci]

Discrepancy Between the In Vitro and In Vivo Effects of Murine Mesenchymal Stem Cells on T Cell Proliferation and Collagen-Induced Arthritis
Whereas mesenchymal stem cells (MSC) inhibit anti-CD3-induced proliferation of T cells in vitro, an effect partially mediated by IFN-gamma, MSC do not influence in vivo T cell proliferation nor the disease course of collagen-induced arthritis. [ Arthritis Res Ther]

Toll-Like Receptor 2 Mediates Mesenchymal Stem Cell Associated Myocardial Recovery and VEGF Production Following Acute Ischemia/Reperfusion Injury
Researchers characterized GD2 ganglioside expression and its implications in umbilical cord blood-derived mesenchymal stem cells. [Cell Mol Life Sci]

Shear Stress Induces Nitric Oxide-Mediated VEGF Production in Human Adipose Tissue Mesenchymal Stem Cells
Results indicate that even though shear stress failed to induce endothelial cell surface markers in human adipose tissue-derived mesenchymal stem cells under the tested conditions, it stimulated nitric oxide-dependent VEGF production. [Stem Cells Dev]

Mesenchymal Stem Cells Inhibit Complement Activation by Secreting Factor H
Results indicate that mesenchymal stem cells (MSC) inhibit complement activation by producing factor H, which could be another mechanism underlying MSCs’ broad immunosuppressive capabilities. [Stem Cells Dev]

Treatment of Metastatic Neuroblastoma with Systemic Oncolytic Virotherapy Delivered by Autologous Mesenchymal Stem Cells: An Exploratory Study
Researchers study the safety and the efficacy of infusing autologous mesenchymal stem cells infected with ICOVIR-5, a new oncolytic adenovirus, for treating metastatic neuroblastoma. [Cancer Gene Ther]



INDUSTRY NEWS

Printing Body Parts – Making a Bit of Me
The ability to make organs as they are needed would not only relieve suffering but also save lives. And that possibility may be closer with the arrival of the first commercial 3D bio-printer for manufacturing human tissue and organs. [The Economist]

Thermo Fisher Said to Offer $6 Billion for Millipore
Thermo Fisher Scientific Inc. made an unsolicited takeover offer of about $6 billion for Millipore Corp., according to a person close to the situation. [Bloomberg Business Week]

Athersys Announces Completion of Patient Enrollment in Phase I Study of Multistem® in Acute Myocardial Infarction
Athersys, Inc. announced that it has completed patient enrollment for its phase I clinical trial of MultiStem®, its allogeneic stem cell therapy product, administered to individuals following acute myocardial infarction. [Athersys, Inc. Press Release]

Stem Cell Firm Cellular Dynamics Raises $40.6 million
Madison-based Cellular Dynamics Inc. has raised $40.6 million, according to a filing the company made with the Securities and Exchange Commission. [Journal Sentinel]

Histostem Participates in Clinical Trials Demonstrating the Effective Use of Its Proprietary Stem Cells in the Treatment of Cirrhosis of the Liver
AmStem Corporation announced that Histostem Ltd. of South Korea has participated in a successful preclinical study of the use of its proprietary Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in the treatment of cirrhosis of the liver. [CNN Money]

University of Minnesota Awarded $8.6 Million Contract to Manufacture Stem Cell Therapies
The University of Minnesota has been awarded an $8.6 million contract to speed the development of novel stem cell and immune cell-based therapies from the laboratory to clinical trials. [University of Minnesota Press Release]



POLICY NEWS

Indian Council of Medical Research to Set Up Apex Committee to Regulate Stem Cell Research
The Indian Council of Medical Research said recently it would soon set up a body to regulate the scientific community on the crucial health research of stem cell therapy. [Indian Council of Medical Research, India]

Study Finds Stem Cell Research in the State of Maryland Supports More than 500 Local Jobs and Facilitates $71.3 Million in Business Sales Annually
A recent third party economic development impact study conducted by Sage Policy Group, Inc., entitled “Economic Benefits of Maryland’s Stem Cell Program already Apparent,” found that Maryland’s Stem Cell Research Fund supports 514 local jobs, with an average salary of $64,000, and facilitates $71.3 million in business sales in the state. [Maryland Stem Cell Research Fund, United States]

2010 Meeting Materials, Vaccines and Related Biological Products Advisory Committee – Draft Agenda, Member Roster [Food and Drug Administration, United States]

National Institutes of Health Stem Cell Guidelines Should Be Modified, University of California, San Francisco Team Reports
A University of California, San Francisco team, led by bioethicist Bernard Lo, MD, recommends that the National Institutes of Health ethics guidelines for embryonic stem cell research be modified to better protect the rights of individuals donating egg or sperm to patients undergoing in vitro fertilization. [National Institutes of Health, United States]

United States “Tweaks” Stem Cell Policy
The U.S. government broadened the definition of a human embryonic stem cell on Friday, helping qualify several corporate and academic experiments for federal funding. [National Institutes of Health, United States]

Status of Certain Human Embryonic Stem Cell Lines (NOT-OD-10-063) [National Institutes of Health, United States]

Review Considerations for Applications and Awards under the New National Institutes of Health Guidelines for Human Stem Cell Research (NOT-OD-10-056) [National Institutes of Health, United States]

UPDATE TO RFA-OD-10-009: OS Recovery Act Limited Competition: Methodology Development in Comparative Effectiveness Research (RC4) Announcement of Non-Applicability of Requirement to Attend Meetings (NOT-OD-10-062) [National Institutes of Health, United States]

Delays in Grant Application Submission to AHRQ due to Recent Winter Storm (NOT-HS-10-013) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30) (PA-10-107) [National Institutes of Health, United States]

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31) (PA-10-108) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (Parent F31 – Diversity) (PA-10-109) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) (PA-10-110) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33) (PA-10-111) [National Institutes of Health, United States]

Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States]

Waivers for Conflicts of Interest for the February 22, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

National Heart, Lung, and Blood Institute Will Provide Limited Supplemental Support to the National Institute of General Medical Sciences Medical Scientist Training Program in FY 2010 (NOT-HL-11-103) [National Heart, Lung, and Blood Institute, United States]

Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Heart, Lung, and Blood Institute, United States]

Expressions of Interest for Membership of the Therapeutic Goods Committee [Therapeutic Goods Administration, Australia]



EVENTS

36th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

9th Transgenic Technology (TT) Meeting
March 22-24, 2010
Berlin, Germany

4th United Kingdom Mesenchymal Stem Cell Meeting
April 14, 2010
Leeds, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

5th World Congress on Preventative and Regenerative Medicine
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States



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