Volume 2.08 | Mar 2

Mesenchymal Cell News 2.08, March 2, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice
Functional mesenchymal stem cells (MSCs) can be clonally generated, beginning at a single-cell level, from human induced pluripotent stem cells (iPSCs). Patient-specific iPSC-MSCs can be prepared as an “off-the-shelf” format for the treatment of tissue ischemia. [Circulation

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SCIENCE NEWS

Study Finds that a Drug Dramatically Reduces Nausea and Vomiting in Bone Marrow Transplant Patients
A recent study has found the drug aprepitant can dramatically reduce both nausea and vomiting when combined with other anti-nausea drugs. [Loyola University Health System Press Release]

M.D. Anderson Researchers Develop Tool to Measure Severity of Chronic Graft-Versus-Host Disease Symptoms
Researchers have developed a new assessment tool to measure the severity of symptoms that can complicate stem cell transplantation. [The University of Texas M.D. Anderson Cancer Center Press Release]

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CURRENT PUBLICATIONS

Clinical-Grade Production of Human Mesenchymal Stromal Cells: Occurrence of Aneuploidy Without Transformation
Researchers investigated the immunologic and genetic features of mesenchymal stromal cells expanded with fetal calf serum and fibroblast growth factor or with platelet lysate in 4 cell-therapy facilities during 2 multicenter clinical trials. [Blood]

Geometric Cues for Directing the Differentiation of Mesenchymal Stem Cells
This work points to the role that geometric shape cues can play in orchestrating the mechanochemical signals and paracrine/autocrine factors that can direct mesenchymal stem cells to appropriate fates. [Proc Natl Acad Sci U S A]

Quantitative Proteomics Analysis of Chondrogenic Differentiation of C3H10T1/2 Mesenchymal Stem Cells by iTRAQ Labeling Coupled with On-Line Two-Dimensional Liquid Chromatography/Mass Spectrometry/Mass Spectrometry
Researchers applied isobaric tag for relative and absolute quantitation labeling coupled with on-line two-dimensional liquid chromatography/mass spectrometry/mass spectrometry technology to identify proteins differentially expressed in an in vitro model for chondrogenesis. [Mol Cell Proteomics]

Human Mesenchymal Stem Cells Overexpressing Pigment Epithelium-Derived Factor Inhibit Hepatocellular Carcinoma in Nude Mice
This study used an orthotopic nude mouse model of hepatocellular carcinoma to evaluate the potential of genetically modified human mesenchymal stem cells, to function as an effective delivery vehicle for therapeutic genes. [ Oncogene]

The Effect of Incorporation of SDF-1(Alpha) into PLGA Scaffolds on Stem Cell Recruitment and the Inflammatory Response
Results support that enhanced recruitment of autologous stem cells can improve the tissue responses to biomaterial implants through modifying/bypassing inflammatory cell responses and jumpstarting stem cell participation in healing at the implant interface. [Biomaterials

Continuous Separation of Cells of High Osteoblastic Differentiation Potential from Mesenchymal Stem Cells on an Antibody-Immobilized Column
Researchers report that two distinctive cell populations with osteoblastic differentiation ability were found in adherent cell populations from bone marrow. [Biomaterials

Proteomic Analysis of Tumor Necrosis Factor-Alpha-Induced Secretome of Human Adipose Tissue-Derived Mesenchymal Stem Cells
Results suggest that tumor necrosis factor-alpha-induced secretome may play a pivotal role of in inflammatory responses and that shotgun proteomic analysis will be useful for elucidation of the paracrine functions of mesenchymal stem cells. [J Proteome Res]

Insulin Expressed from Endogenously Active Glucose-Responsive EGR1 Promoter in Bone Marrow Mesenchymal Stromal Cells as Diabetes Therapy
Results establish human EGR1 promoter-insulin construct-modified bone marrow-derived mesenchymal stromal cells as safe and efficient insulin-secreting bioimplants for diabetes treatment. [Gene Ther]

Long-Term Dynamic Loading Improves the Mechanical Properties of Chondrogenic Mesenchymal Stem Cell-Laden Hydrogel
Results demonstrate, for the first time, that dynamic compressive loading initiated after a sufficient period of chondro-induction and with sustained TGF-beta exposure enhances matrix distribution and the mechanical properties of mesenchymal stem cell-seeded constructs. [Eur Cell Mater]

Autocrine Production of TGF-(Beta)1 Promotes Myofibroblastic Differentiation of Neonatal Lung Mesenchymal Stem Cells
Researchers conclude that human neonatal lung mesenchymal stem cells (MSCs) demonstrate an mRNA expression pattern characteristic of myofibroblast progenitor cells. Autocrine production of TGF-(beta)1 further drives myofibroblastic differentiation, suggesting that, in the absence of other signals, fibrosis represents the “default program” for neonatal lung MSC gene expression. [Am J Physiol Lung Cell Mol Physiol]



INDUSTRY NEWS

New Study Demonstrates Effectiveness of Prochymal as a Rescue Therapy for Pediatric Patients with Severe Graft vs. Host Disease
Osiris Therapeutics, Inc. reported that a new study shows Prochymal achieved an overall response rate of 63% when used as a rescue therapy in children suffering from severe treatment resistant graft vs. host disease. [Osiris Therapeutics, Inc. Press Release]

Investigators Present Phase III Data for Prochymal in Steroid-Refractory Graft vs. Host Disease
Osiris Therapeutics, Inc. announced that results from the Phase III trial evaluating Prochymal for the treatment of steroid-refractory acute graft vs. host disease will be presented by Paul Martin, M.D., of the Fred Hutchinson Cancer Research Center and Paul Szabolcs, M.D., of Duke University Medical Center at the 2010 Blood and Marrow Transplant Tandem Meeting. [Osiris Therapeutics, Inc. Press Release]

Merck KGaA and Millipore Announce Transaction
Merck KGaA and Millipore Corporation recently announced that they have entered into a definitive agreement under which Merck KGaA will acquire all outstanding shares of common stock of Millipore, for US$107 per share in cash, or a total transaction value, including net debt, of approximately US$7.2 billion. [Merck KGaA Press Release]

Startup Joins University of California, Los Angeles Tech Incubator to Develop Technologies for Drug Discovery, Screening
Librede Inc. has joined the University of California, Los Angeles on-campus technology incubator space at the California NanoSystems Institute, where the startup company will work on developing technologies to improve ion channel drug discovery and screening. [California NanoSystems Institute Press Release]

Aastrom Reports Interim Results from Critical Limb Ischemia Trial
Aastrom Biosciences, Inc. reported results from a planned interim analysis of the company’s multi-center, randomized, double-blind, placebo-controlled U.S. Phase IIb clinical trial designated RESTORE-CLI. [Aastrom Biosciences, Inc. Press Release]

$1.9 Billion in Research to Focus on Protecting Soldiers
The Army’s fiscal 2011 science and technology budget that recently went forward for approval tops out at $1.9 billion and includes funding for advanced medical and force-protection research efforts. [United States Army Press Release]

Oklahoma Tobacco Settlement Endowment Trust Provides $5.5 Million in Seed Money for Adult Stem Cell Research
The Board of Directors of the Oklahoma Tobacco Settlement Endowment Trust during its quarterly meeting approved a proposal creating a virtual research center to be known as the Oklahoma Center for Adult Stem Cell Research. [Oklahoma Tobacco Settlement Endowment Trust Press Release]

Stempeutics to Launch Its Stem Cell Based New Drug in India by 2012
Stempeutics Research is all set to introduce its investigational new drug in India by 2012. The drug is being developed in India for acute myocardial infarction and critical limb ischemia. [PharmaBiz Press Release]



POLICY NEWS

National Institutes of Health Director Goes Shopping
Francis Collins, the new leader of National Institutes of Health, announced that he will spend more than $200 million out of the Common Fund over the next five years on seven programmes in areas ranging from global health to how to speed therapies to the clinic. [National Institutes of Health, United States]

Massachusetts Life Sciences Center Awards $6.6 Million Grant for Next Phase of Development at Gateway Park
The Massachusetts Life Sciences Center Board of Directors recently awarded a $6.6 million grant to Worcester Polytechnic Institute to support the next phase of life sciences related development at Gateway Park in Worcester. [Massachusetts Life Sciences Center, United States]

Massachusetts Life Sciences Center Launches 2010 Accelerator Program for Early-Stage Companies
The primary objective of the Accelerator Loan Program is to provide working capital to early stage life sciences companies that still are in the process of further developing their science/technology and have not yet raised more than $5 million in equity financing. [Massachusetts Life Sciences Center, United States]

Agency Information Collection Activities; Proposals, Submissions, and Approvals; Human Tissue Intended for Transplantation, 9226-9227 [FDA-2010-N-0066] [Food and Drug Administration, United States]

National Institute of Arthritis and Musculoskeletal and Skin Diseases Accelerating Research Translation in Musculoskeletal and Skin Tissue Engineering and Regenerative Medicine Competitive Revision Award (R01) (RFA-AR-11-004) [National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States]

National Institute of Arthritis and Musculoskeletal and Skin Diseases Accelerating Research Translation in Musculoskeletal and Skin Tissue Engineering and Regenerative Medicine Competitive Revision Award (P01 and P50) (RFA-AR-11-005) [National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States]

Cross Organ Mechanism-Associated Phenotypes for Genetic Analyses of Heart, Lung, Blood, and Sleep Diseases (MAPGen for HLBS) Research Centers (U01) (RFA-HL-11-005) [National Heart, Lung, and Blood Institute, United States]

National Heart, Lung, and Blood Institute Will Provide Limited Supplemental Support to the National Institute of General Medical Sciences Medical Scientist Training Program in FY 2010 (NOT-HL-11-103) [National Heart, Lung, and Blood Institute, United States]

2010 Meeting Materials, Vaccines and Related Biological Products Advisory Committee Meeting – Draft Agenda, Member Roster [Food and Drug Administration, United States]

Notice from the John E. Fogarty International Center with Corrections Made to PAR-10-065: Independent Scientist in Global Health Award (ISGHA) (K02) (NOT-TW-10-002) [National Institutes of Health, United States]

Advancing Regulatory Science through Novel Research and Science-Based Technologies (U01) (RFA-RM-10-006) [National Institutes of Health, United States]

Review Considerations for Applications and Awards under the New National Institutes of Health Guidelines for Human Stem Cell Research (NOT-OD-10-056) [National Institutes of Health, United States]

UPDATE TO RFA-OD-10-009: OS Recovery Act Limited Competition: Methodology Development in Comparative Effectiveness Research (RC4) – Announcement of Non-Applicability of Requirement to Attend Meetings (NOT-OD-10-062) [National Institutes of Health, United States]

Delays in Grant Application Submission to AHRQ due to Recent Winter Storm (NOT-HS-10-013) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30) (PA-10-107) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Parent F31) (PA-10-108) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (Parent F31 – Diversity) (PA-10-109) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) (PA-10-110) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33) (PA-10-111) [National Institutes of Health, United States]

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]

Expressions of Interest for Membership of the Therapeutic Goods Committee [Therapeutic Goods Administration, Australia]



EVENTS

36th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

9th Transgenic Technology (TT) Meeting
March 22-24, 2010
Berlin, Germany

4th United Kingdom Mesenchymal Stem Cell Meeting
April 14, 2010
Leeds, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States



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