Volume 2.12 | Mar 30

Mesenchymal Cell News 2.12, March 30, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Duke Scientists Uncover Cells that Mend a Broken Heart
This study showed that the major contributors to the regeneration of surgically removed heart muscle came from a subpopulation of cardiomyocytes near the area where the removal occurred. [Press release from Duke University Medical Center discussing online prepublication in Nature]

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SCIENCE NEWS


Surprising New Clues on How to Build a Heart
New studies of how the heart develops in growing mouse embryos have brought researchers a step closer to understanding how to induce the body’s own cells to rebuild damaged coronary arteries. [Press release from Howard Hughes Medical Institute discussing online prepublication in Nature]

Biologic Joint Reconstruction Using Stem Cells Proven Successful in Patients with Arthritis
Biologic Joint Reconstruction, rather than bionic replacement, may be an appropriate first step for many people with knee joint arthritis. [PRWeb Press Release]

Scientist Grows Jaw Bone from Adult Stem Cells
A Columbia scientist has become the first to grow a complex, full-size bone from human adult stem cells. [Press release from Columbia University discussing online prepublication in Proceedings of the National Academy of Sciences USA]

Using Nanotechnology in Cancer Research
Biomedical researchers in Bergen are applying nanotechnology to mimic the body’s natural processes, create new blood vessels to supply engineered tissue, and deepen our understanding of cancer. [Science Daily Press Release]

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CURRENT PUBLICATIONS

Primary Contribution to Zebrafish Heart Regeneration by gata4+ Cardiomyocytes
Results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations. [Nature]

Zebrafish Heart Regeneration Occurs by Cardiomyocyte Dedifferentiation and Proliferation
The researchers’ data provide the first direct evidence for the source of proliferating cardiomyocytes during zebrafish heart regeneration and indicate that stem or progenitor cells are not significantly involved in this process. [Nature]

Bone Progenitor Dysfunction Induces Myelodysplasia and Secondary Leukemia
By examining how mesenchymal osteolineage cells modulate hematopoiesis, researchers show that deletion of Dicer1 specifically in mouse osteoprogenitors, but not in mature osteoblasts, disrupts the integrity of hematopoiesis. [Nature]

Gli1 Regulates the Proliferation and Differentiation of Hematopoietic Stem Cells and Myeloid Progenitors
These data demonstrate that Gli1 regulates normal and stress hematopoiesis. Moreover, they suggest that Gli1 and Smoothened may not be functionally redundant, and direct GLI1 inhibitors may be needed to effectively block HH/GLI1 activity in human disease. [Blood]

MCP1 Directs Trafficking of Hematopoietic Stem Cell-Derived Fibroblast Precursors in Solid Tumor
Researchers demonstrate using a single cell transplantation model that circulating fibroblast precursors are of hematopoietic stem cell origin. [Am J Pathol]

Neuroprotective Effects of Intravitreal Mesenchymal Stem Cell Transplantation in Experimental Glaucoma
The present study was conducted to determine whether local or systemic bone marrow-derived mesenchymal stem cell transplantation can confer neuroprotection in a rat model of laser-induced ocular hypertensive glaucoma. [Invest Ophthalmol Vis Sci]

Mechanisms for Osteogenic Differentiation of Human Mesenchymal Stem Cells Induced by Fluid Shear Stress
Researchers describe how human mesenchymal stem cells respond to fluid flow stimuli and focus on the signal molecules involved in this mechanotransduction. [Biomech Model Mechanobiol]

DLK-1 as a Marker to Distinguish Unrestricted Somatic Stem Cells and Mesenchymal Stromal Cells in Cord Blood
Investigators demonstrate that the expression of genes and the differentiation towards the adipogenic lineage can discriminate between mesenchymal stromal cells and unrestricted somatic stem cells. [Stem Cells Dev]

Type I Collagen Promotes Proliferation and Osteogenesis of Human Mesenchymal Stem Cells via Activation of ERK and Akt Pathways
The goal of this study was to identify the best extracellular matrix protein for enhancing osteogenesis by human mesenchymal stem cells and to investigate the underlying mechanism. [J Biomed Mater Res A]

Human Adipose-Derived Stem Cells Proliferate and Differentiate in Osteoblast-Like Cells on Trabecular Titanium Scaffolds
The aim of this study was to evaluate with biochemical and morphological methods the adhesion and differentiation of human adipose tissue-derived stem cells grown on trabecular titanium scaffolds. [J Biomed Mater Res A]



INDUSTRY NEWS

Aastrom Announces Treatment of Final Patient in RESTORE-CLI Clinical Trial
Aastrom Biosciences, Inc. reported that the final patient has been treated in the company’s ongoing multi-center, randomized, double-blind, placebo-controlled U.S. Phase IIb clinical trial designated RESTORE-CLI. [Aastrom Biosciences, Inc. Press Release]

CryoLife Withdraws Its Proposal to Acquire Medafor
Based on the limited information that Medafor has made available to its shareholders, CryoLife continues to believe that the Medafor board’s stated strategic rationale for entering into the Magle transaction does not justify the significant dilution suffered by Medafor shareholders. [CryoLife, Inc. Press Release]

Bioheart Announces Cell Therapies Program in Latin America for Congestive Heart Failure and Peripheral Arterial Disease Patients
Bioheart, Inc., announced plans for establishing five Centers of Excellence in Latin America to provide its cell therapy procedures to patients suffering from congestive heart failure and peripheral arterial disease beginning, April 2010. [PRNewswire]

Garnet BioTherapeutics Announces First Patient Treated in Trial of New Therapy for Improvement in Scar Appearance
Garnet BioTherapeutics announced that the first patient has been treated in a Phase II multicenter, double-blind, placebo-controlled study of its lead product candidate GBT009 at Unity Hospital in Rochester, New York. [Garnet BioTherapeutics Press Release]

The Automation Partnership (TAP) and AVISO Sign Second Distribution Agreement for TAP to Exclusively Market CellCelector™ in the UK and Ireland
The Automation Partnership announced it has entered into a second distribution agreement with AVISO GmbH, a major German manufacturer of automation for the stem cell market. [The Automation Partnership Press Release]

Funding for Cardiovascular Regeneration Research
Research into cardiovascular regeneration has been given a boost with a grant of over £550,000 by the British Heart Foundation. [Bristol Heart Institute Press Release]

Newly Established Firm Aims to Speed Development of Stable Cell Lines and Primary Cells for R&D
A new service company focused on the development of customized cells for drug discovery and development applications has been spun-out from Germany’s Helmholtz Centre for Infection Research. [Genetic Engineering & Biotechnology News]

Biotechs, Venture Capitalists Shoot, Score with Reform
Looking for a couple of winners out of the House’s historic passage of so-called health care reform – otherwise known as March Madness? Consider the biotech industry and its venture capital backers. [San Francisco Business Times]

Abbreviated Trials Yield Misleading Results: Study
Many positive treatment effects are exaggerated in clinical trials that are stopped early due to encouraging results, a new study has found. [HealthDay News]

BloodCenter to Operate Organ, Tissue Bank
Two groups that procure organs, veins, heart valves and other tissue have been consolidated into the BloodCenter of Wisconsin, making it the only organization in the country that specializes in all types of donation. [Journal Sentinel]

Health Reform Will Set Off Biotech Tax Credit Rush
New research credit, capped at $1 billion, should be a bonanza for some small and medium-sized firms and their investors. [Forbes]



POLICY NEWS

Government Accountability Office: FDA Needs Better Plans To Protect Public Health
The U.S. Food and Drug Administration is facing significant planning and management challenges that could affect its ability to protect the public health, according to a report by the Government Accountability Office. [Food and Drug Administration, United States]

Carl Wieman Chosen for White House Science Post
Physicist Carl Wieman has been picked to be associate director for science in the White House Office of Science and Technology Policy. [Office of Science and Technology Policy, United States]

Notice of Intent to Publish a Request for Applications for The Heart Failure Clinical Research Network (U10) (NOT-HL-11-106) [National Institutes of Health, United States]

Notice of Termination of Selected Research Training and Research Career Development Award Funding Opportunity Announcements (NOT-OD-10-069) [National Institutes of Health, United States]

Final Ruth L. Kirschstein National Research Service Award (Kirschstein-NRSA) Policy for Tuition, Fees, and Health Insurance on Training Grants and Fellowships (NOT-OD-10-073) [National Institutes of Health, United States]

Waivers for Conflicts of Interest for the April 12, 2010 Blood Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

Guidance for Industry on the Content and Format of the Dosage and Administration Section of Labeling for Human Prescription Drug and Biological Products; Availability [Docket No. FDA-2007-D-0201] [Food and Drug Administration, United States]

Advisory Committees; Technical Amendment [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practices; Public Workshop [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Consultation: Proposed Standards for Hematopoietic Progenitor Cells Intended for Use in Hematopoietic Reconstitution [Therapeutic Goods Administration, Australia]



EVENTS

4th United Kingdom Mesenchymal Stem Cell Meeting
April 14, 2010
Leeds, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North American 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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