Volume 2.13 | Apr 6

Mesenchymal Cell News 2.13, April 6, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Promoting Healing by Keeping Skeletal Stem Cells ‘Young’
Scientists seeking new ways to fight maladies ranging from arthritis and osteoporosis to broken bones that won’t heal have cleared a formidable hurdle, pinpointing and controlling a key molecular player to keep stem cells in a sort of extended infancy. [Press release from the University of Rochester Medical Center discussing online prepublication in Development]

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SCIENCE NEWS

Researchers Find a Better Way to Track Stem Cells
Researchers have found that using the Food and Drug Administration-approved contrast agent Indocyanine Green to label human embryonic stem cell-derived cardiomyocytes substantially improved efforts to optically track stem cells after transplanting them into heart tissues. [Press release from EurekaAlert! discussing online prepublication in Cell Transplantation]

Gene Therapy Boosts Recovery from Heart Attack
In a new study, researchers in Bristol investigated whether nerve growth factor could help the heart recover from a heart attack by encouraging new blood vessels to grow into and nourish the injured muscle. [Press release from the University of Bristol discussing online prepublication in Circulation Research]

Stem Cells from Menstrual Blood May Benefit Stroke Patients
Cryo-Cell International, Inc. announced results of a study published recently showing that stem cells found in menstrual blood may one day be a potential source for stem cell therapies in stroke and other central nervous system disorders. [Press release from Cryo-Cell International, Inc. discussing online prepublication in Stem Cells and Development]

Recent Advances Lead to a Breakthrough Method for Expanded Medical Use of Adult Stem Cells
At a recent scientific symposium, Vitro Diagnostics, Inc. scientists presented their evidence that expression of a single gene within adult stem cells resulted in expanded differentiation capacity comparable to embryonic stem cells that have the capacity to differentiate into any cell of the body. [Market Wire Press Release]

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CURRENT PUBLICATIONS

A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function
Using cardiac-specific RNAi-silencing in Drosophila, researchers knocked down 7061 evolutionarily conserved genes under conditions of stress. Researchers present a first global roadmap of pathways potentially playing conserved roles in the cardiovascular system. [Cell]

A Purified Population of Multipotent Cardiovascular Progenitors Derived from Primate Pluripotent Stem Cells Engrafts in Postmyocardial Infarcted Nonhuman Primates
Researchers report the isolation of an early population of cardiovascular progenitors, characterized by expression of OCT4 , stage-specific embryonic antigen 1, and mesoderm posterior 1, derived from human pluripotent stem cells treated with the cardiogenic morphogen BMP2. [J Clin Invest]

Nerve Growth Factor Promotes Cardiac Repair Following Myocardial Infarction
To investigate the nerve growth factor (NGF) therapeutic potential, human NGF gene or control (empty vector) was delivered to the murine periinfarct myocardium. [Circ Res]

Recapitulation of Endochondral Bone Formation Using Human Adult Mesenchymal Stem Cells as a Paradigm for Developmental Engineering
This study reveals the capacity of human mesenchymal stem/stromal cells to generate bone tissue via an endochondral program and provides a valid model to study mechanisms governing bone development. [Proc Natl Acad Sci U S A]

RBPjK-Dependent Notch Signaling Regulates Mesenchymal Progenitor Cell Proliferation and Differentiation During Skeletal development
To determine the exact role and mode of action for the Notch pathway in mesenchymal progenitor cells (MPCs) during skeletal development, researchers analyzed tissue-specific loss-of-function, gain-of-function, and RBPjk -independent Notch gain-of-function mice for defects in MPC proliferation and differentiation. [Development]

Labeling Human Embryonic Stem Cell-Derived Cardiomyocytes with Indocyanine Green for Noninvasive Tracking with Optical Imaging: A Food and Drug Administration-Compatible Alternative to Firefly Luciferase
The purpose of this study was to develop a labeling technique for human embryonic stem cells and human embryonic stem cell-derived cardiomyocytes with the Food and Drug Administration-approved contrast agent indocyanine green for optical imaging. [Cell Transplant]

Mesenchymal Stem Cell Transplantation in Amyotrophic Lateral Sclerosis: A Phase I Clinical Trial
The objectives of this Phase I clinical study were to assess the feasibility and toxicity of mesenchymal stem cell transplantation and to test the impact of a cell therapy in Amyotrophic Lateral Sclerosis patients. [Exp Neurol

Menstrual Blood Cells Display Stem Cell-Like Phenotypic Markers and Exert Neuroprotection Following Transplantation in Experimental Stroke
In order to test the therapeutic potential of menstrual blood-derived stem cells, researchers used the in vitro stroke model of oxygen glucose deprivation (OGD) and found that OGD-exposed primary rat neurons that were co-cultured with menstrual blood-derived stem cells or exposed to the media collected from cultured menstrual blood exhibited significantly reduced cell death. [Stem Cells Dev]

High Recovery of Mesenchymal Progenitor Cells with Non-Density Gradient Separation of Human Bone Marrow
Investigators compared the feasibility and reproducibility of two gravity separation techniques, with or without the use of a density gradient, in terms of both hematopoietic and mesenchymal human bone marrow progenitors. [Cytotherapy]



INDUSTRY NEWS

Louisiana State University Researcher Receives Grant to Study Equine Adult Stem Cells
Dr. Mandi Lopez, associate professor and director of the Louisiana State University Laboratory for Equine and Comparative Orthopedic Research, is the recipient of a competitive grant award from the Grayson-Jockey Club Research Foundation to study equine adult stem cells for repair of injured bone. [Louisiana State University Press Release]

University of Rochester Medical Center Receives $4.5 Million in New York State Stem Cell Grants
The University of Rochester Medical Center has received a total of $4.5 million in funding from the Empire State Stem Cell Board for research in neurological disease, cancer, cardiovascular disease, and bone repair. [University of Rochester Medical Center Press Release]

Boehringer Ingelheim Launches Global Venture Fund to Foster Innovation in Life Sciences
Boehringer Ingelheim announced the launch of its corporate venture capital fund, the Boehringer Ingelheim Venture Fund. [Boehringer Ingelheim Press Release]

Juventas Therapeutics Enrolling Phase I Clinical Trial of JVS-100 for Patients with Heart Failure
Juventas Therapeutics announced it has started enrolling patients in a Phase I clinical trial for JVS-100 to evaluate safety and efficacy in the treatment of patients with Class III heart failure. [PR Newswire]

Aderans Research Institute Inc. Purchases Intercytex Assets
Aderans Research Institute Inc. announced it acquired key technology assets from Regenerative Medicine Assets. [PR Web]

Health Reform Will Set Off Biotech Tax Credit Rush
New research credit, capped at $1 billion, should be a bonanza for some small and medium-sized firms and their investors. [Forbes]



POLICY NEWS

Key Budget Question: $12.4 Million or $6.2 Million for Stem Cell Funding?
A General Assembly budget conference committee started discussions recently to seek a resolution on how much to allocate for stem cell research grants in fiscal 2011, with the House and Senate versions on the legislation far apart. [United States General Assembly, United States]

Judge Invalidates Human Gene Patent
A federal judge struck down patents on two genes linked to breast and ovarian cancer. The decision, if upheld, could throw into doubt the patents covering thousands of human genes and reshape the law of intellectual property. [United States District Court, United States]

Enhancing Peer Review: Updated Processes for the Review of All Ruth L. Kirschstein National Research Service Award Fellowship Applications (NOT-OD-10-071) [National Institutes of Health, United States]

National Institutes of Health Will Require the Electronic Submission of Appointment Forms and Termination Notices via xTrain for Research Training, Fellowship, Education, and Career Awards Beginning January 2011 (NOT-OD-10-072) [National Institutes of Health, United States]

Small Business Innovation Research Award Levels Adjusted to $150,000 (Phase I) and $1,000,000 (Phase II) (NOT-OD-10-079) [National Institutes of Health, United States]

Notice of Change in Expiration Date for Program Announcement on Bioengineering Research Partnerships (PAR-07-352) (NOT-EB-10-001) [National Institutes of Health, United States]

2010 Biological License Application Supplement Noteworthy Approvals [Center for Biologics Evaluation and Research, United States]

Revision of the Requirements for Constituent Materials [Docket No. FDA-2010-N-0099] [Food and Drug Administration, United States]

Voting and Nonvoting Consumer Representative Members on Public Advisory Committees and Panels; Notice of Public Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Determination of Regulatory Review Period for Purposes of Patent Extension; LUSEDRA [Docket Nos. FDA-2009-E-0202 and FDA-2009-E-0204] [Food and Drug Administration, United States]

Revision of Organization and Conforming Changes to Regulations [Docket No. FDA-2010-N-0148] [Food and Drug Administration, United States]

Administrative Practices and Procedures; Good Guidance Practices; Technical Amendment [Docket No. FDA-1999-N-3539] [Food and Drug Administration, United States]



EVENTS

4th United Kingdom Mesenchymal Stem Cell Meeting
April 14, 2010
Leeds, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North American 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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