Volume 2.20 | May 25

Mesenchymal Cell News 2.20, May 25, 2010.
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TAZ as a Novel Enhancer of MyoD-Mediated Myogenic Differentiation
In this study, researchers investigated whether TAZ (transcriptional coactivator with PDZ-binding motif) affects myoblast differentiation, which is one of the differentiated lineages of mesenchymal stem cells. [FASEB J]

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UT Researcher Develops New Method of Stem Cell Culture
Cultivating enough stem cells for clinical use has always been extremely difficult and time-consuming, but now Deborah Schop of the University of Twente has developed a new method of mesenchymal stem cell culture, using a closed system: a bioreactor. [University of Twente Press Release]

Protein Linked to Fat Cell Development
Removal of the protein S6K1 slows the formation of new adipocytes. Researchers say the finding suggests that S6K1 could be directly targeted for treating or preventing obesity. [Press release from the University of Cincinnati discussing online prepublication in Developmental Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

S6K1 Plays a Critical Role in Early Adipocyte Differentiation
Here researchers report that adipocytes of S6K1-/- mice on a high fat diet have the capacity to increase in size to a degree comparable to that of wild-type mice, but not in number, indicating an unexpected lesion in adipogenesis. [Dev Cell]

Bone Osteoblastic and Mesenchymal Stromal Cells Lack Primarily Tumoral Features in Multiple Myeloma Patients
Mesenchymal stromal cells and osteoblasts assume a critical role in tumorigenesis either through the overproduction of growth factors and osteoclastogenic molecules or by undergoing alterations responsible for the suppression of bone formation that rarely repairs even after disease remission. [Leukemia]

Urinary Bladder Smooth Muscle Regeneration Utilizing Bone Marrow Derived Mesenchymal Stem Cell Seeded Elastomeric Poly(1,8-Octanediol-Co-Citrate) Based Thin Films
Researchers hypothesized that human mesenchymal stem cells seeded onto poly(1,8-octanediol-co-citrate) elastomeric thin films would provide a suitable milieu for partial bladder regeneration. [Biomaterials]

The Influence of an Aligned Nanofibrous Topography on Human Mesenchymal Stem Cell Fibrochondrogenesis
This study assessed the ability of human marrow-derived mesenchymal stem cells to elaborate a mechanically functional, fibrocartilaginous matrix in a nanofibrous microenvironment. [Biomaterials]

Branched Oligomerization of Cell-Permeable Peptides Markedly Enhances the Transduction Efficiency of Adenovirus into Mesenchymal Stem Cells
In this study, branched oligomerization of cell-permeable peptides (CPPs) significantly enhanced the transduction of human mesenchymal stem cells by recombinant adenovirus in a CPP type-independent manner. [Gene Ther]

Parsing the Early Cytoskeletal and Nuclear Organizational Cues that Demarcate Stem Cell Lineages
Using a high-content imaging-based profiling tool, researchers demonstrate that human mesenchymal stem cells induced to differentiate to either osteogenic or adipogenic lineages are discernable within the first 24 hours from each other and from non-differentiating cells. [Cell Cycle]


United States FDA Clears Phase II Trial for Cervical Spinal Fusion
Australia’s regenerative medicine company, Mesoblast Limited, announced that it has received clearance from the United States Food and Drug Administration to begin Phase II clinical trials of its “off-the-shelf” or allogeneic stem cell product NeoFuse™ for fusion of the cervical spine in the neck. [Mesoblast Limited Press Release]

Cytori Sells First U.S. StemSource(R) Cell Bank
Cytori Therapeutics has sold its first StemSource(R) Cell Bank in the United States. [Cytori Therapeutics Press Release]

Rensselaer Polytechnic Institute Wins $2.45 Million Grant To Support Stem Cell Research
Rensselaer Polytechnic Institute and principal investigator Glenn Monastersky have been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program of the Empire State Stem Cell Board. [Rensselaer Polytechnic Institute Press Release]

Maryland Stem Cell Research Commission Announces 42 Projects for Funding
The Maryland Stem Cell Research Commission has completed its evaluation of the 141 applications in response to its three official Requests for Applications during the FY 2010 funding cycle. [Maryland Stem Cell Research Commission Press Release]

HHMI Awards $79 Million for Science Education to Research Universities, Top Scientists
Howard Hughes Medical Institute (HHMI) announced new grants totaling $79 million that will help universities strengthen undergraduate and precollege science education nationwide. [Howard Hughes Medical Institute Press Release]


House Nixes More Research Spending in COMPETES Bill
Catching the Democratic leadership by surprise, members voted 292 to 126 to block passage of a 5-year authorization bill that would have provided healthy increases in the research and education budgets of the National Science Foundation and research programs at the Department of Energy and the Department of Commerce. [House of Representatives, United States]

NIH Wants More (Not Total) Disclosure of Financial Conflicts
The federal government proposed an overhaul of regulations covering financial conflicts of interest in biomedical research. The rules would expand the amount of information that researchers must report to their institutions, make some of it public, and require that more details than in the past be submitted privately to the National Institutes of Health. [National Institutes of Health, United States]

NIH Requests Comments on the Proposed Rule Applicable to Regulations on the Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors (NOT-OD-10-099) [National Institutes of Health, United States]

Notice of Format Clarification and Frequently Asked Questions (FAQs) for Funding Opportunity Announcement (FOA): RFA-HL-11-006, Next Generation Genetic Association Studies (U01) (NOT-HL-10-110) [National Institutes of Health, United States]

Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health Service Funding Is Sought and Responsible Prospective Contractors; Proposed Rule (Docket Number: NIH-2010-0001) [National Institutes of Health, United States]

FDA Transparency Initiative: Draft Proposals for Public Comment Regarding Disclosure Policies of the U.S. Food and Drug Administration; Availability [Docket No. FDA-2009-N-0247] [Food and Drug Administration, United States]

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