Volume 2.21 | Jun 1

Mesenchymal Cell News 2.21, June 1, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Stem Cell Disruption Induces Skull Deformity, UR Study Shows
Scientists discovered a defect in cellular pathways that provides a new explanation for the earliest stages of abnormal skull development in newborns, known as craniosynostosis. [Press release from the University of Rochester Medical Center discussing online prepublication in Science Signaling]

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SCIENCE NEWS

New Source of Stem Cells Form Heart Muscle Cells, Repair Damage
Investigators in Japan used the amniotic membrane to obtain human amniotic membrane-derived mesenchymal cells. [Press release from ScienceDaily discussing online prepublication in Circulation Research]

UA Doctor Studies Stem Cell Use in Cardiac Recovery
A Tucson cardiologist is part of a national trial that’s testing whether human mesenchymal stem cells can help repair the hearts of people who have just suffered heart attacks. [Arizona Daily Star]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development
Here, researchers show that endochondral ossification, a type of bone formation that proceeds through a cartilage intermediate, caused by switching the fate of mesenchymal stem cells to chondrocytes, can also result in craniosynostosis. [Sci Signal]

Xenografted Human Amniotic Membrane-Derived Mesenchymal Stem Cells Are Immunologically Tolerated and Transdifferentiated Into Cardiomyocytes
The objective of this study was to determine whether human amniotic membrane-derived mesenchymal cells can be an ideal allograftable stem cell source for cardiac regenerative medicine. [Circ Res]

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype
Because of the deleterious role of Th17 cells in the pathogenesis of inflammatory disease, researchers investigated whether proinflammatory cytokines could modify the expression of adhesion molecules on human mesenchymal stem cells (MSCs), thereby contributing to increased Th17 cell adhesion to MSCs and, as a consequence, modulating the function of the latter cells. [J Immunol]

Tumor Cell Behaviour Modulation by Mesenchymal Stromal Cells
Researchers aimed to show whether multipotent mesenchymal stromal cells derived from human adipose tissue could create tumor cell-protective milieu and affect tumor cell behaviour in vitro and in vivo. [Mol Cancer]

shRNA-Mediated Decreases in c-Met Levels Affect the Differentiation Potential of Human Mesenchymal Stem Cells and Reduce Their Capacity for Tissue Repair
The current study highlights the significance of HGF/c-Met signaling in the capacity of mesenchymal stem cells to restore blood flow after an ischemic injury and in their ability to differentiate into the osteogenic and chondrogenic lineages. [Tissue Eng Part A]

High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells by Tyrosine-Mutant AAV2 Vectors for Their Potential Use in Cellular Therapy
In the current studies, researchers evaluated the transduction efficiency of single as well as multiple tyrosine-mutant adeno-associated virus 2 (AAV2) vectors in murine fibroblasts. [Hum Gene Ther]


INDUSTRY NEWS

DFG Approves 12 New Collaborative Research Centers
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) has approved the establishment of twelve new Collaborative Research Centers. [Dutch Research Foundation Press Release]

t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA
t2cure GmbH announced that the quality of its lead product t2c001 has been certified by the European Medicines Agency (EMA). t2c001 is the first product ever to obtain a certificate under the EMA regulations for Advanced Therapy Medicinal Products. [t2cure GmbH Press Release]

Glycosan BioSystems Seeks CE Mark in the European Union for HyStem-Rx, a Unique, Implantable Scaffold for Tissue Engineering
Glycosan BioSystems announced that the Company has begun the process for gaining regulatory approval within the European Union for the use of HyStem-Rx as a resorbable scaffold for implanting autologous adipose derived cells in reconstruction and aesthetic plastic surgery procedures. [PR Newswire]


POLICY NEWS

Treasury Releases New Guidance for Tax Credit in Affordable Care Act to Support Groundbreaking Biomedical Research
The U.S. Department of the Treasury announced the guidelines for applying for the new Therapeutic Discovery Project Program created by the Affordable Care Act. [Department of the Treasury, United States]

Third Time’s a Charm for COMPETES Bill
By a vote of 262 to 150, legislators authorized $84 billion for research, education, and innovation programs over the next 5 years at the National Science Foundation, the Department of Energy, and two Department of Commerce agencies – NOAA and NIST under the America COMPETES Reauthorization Act (HR 5116). [House of Representatives, United States]

Democrats: FDA Should Be Able to Recall Drugs
House Democrats repeatedly called for federal regulators to be given the authority to recall drugs. Pending legislation would grant that power to the Food and Drug Administration (FDA) for food, but not for drugs. [House of Representatives, United States]

Last Hurrah from National Academies Stem Cell Committee
Even though the National Institutes of Health issued stem cell guidelines last year, there’s still a need for guidelines for research that remains off-limits for U.S. government-funded labs. [National Academies’ National Research Council and Institute of Medicine, United States]

NIH Set to Tighten Financial Rules for Researchers
After a wave of financial scandals over the past few years involving biomedical researchers, the U.S. National Institutes of Health (NIH) proposed far-reaching changes that would lead to tighter oversight of agency-funded extramural investigators and their institutions. [National Institutes of Health, United States]

Request for Information (RFI) on the NIH Plan to Develop the Genetic Testing Registry (NOT-OD-10-101)
[National Institutes of Health, United States]

Administrative Supplements to Advance Special Translational Research Acceleration Projects on Immune Response Modifiers Currently Funded by the National Cancer Institute (NCI) (NOT-CA-10-025) [National Institutes of Health, United States]

Exceptions and Alternative Procedures Approved Under 21 CFR 640.120 [Food and Drug Administration, United States]


EVENTS

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.

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