Volume 2.23 | Jun 15

Mesenchymal Cell News 2.23, June 15, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Osteogenic Protein-1 Associated with Mesenchymal Stem Cells Promote Bone Allograft Integration
The results demonstrated that the association of mesenchymal stem cells and osteogenic protein-1 improve bone allograft integration promoting an almost complete bone restoring. [Tissue Eng Part A]

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SCIENCE NEWS

Tissue Regenreation Research Could Help Keep Seniors Active
Researchers are trying to develop the technique where stem cells from fat are placed on a polymer prosthetic that stimulates cell growth and that is later implanted it into a person’s body. [Queen’s University Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Baculovirus-Transduced Bone Marrow Mesenchymal Stem Cells for Systemic Cancer Therapy
The findings suggest that baculoviral transduction of mesenchymal stem cells is an attractive option to generate targeting vehicles for systemic cancer therapy. [Gene Ther]

Intranigral Transplantation of Epigenetically-Induced BDNF-Secreting Human Mesenchymal Stem Cells: Implications for Cell-Based Therapies in Parkinson´s Disease
The aim of the present study was to characterize signals and/or molecules that regulate brain-derived neurotrophic factor (BDNF) protein expression/delivery in human mesenchymal stem cell (hMSC) cultures and evaluate the effect of epigenetically generated BDNF-secreting hMSC on the intact and lesioned substantia nigra. [Biol Blood Marrow Transplant]

Long-Term Efficacy and Safety of Human Umbilical Cord Mesenchymal Stromal Cells in Rotenone-Induced Hemiparkinsonian Rats
In this study, researchers investigated migration, therapeutic, tumorigenesis and epileptogenic effects of human umbilical cord mesenchymal stromal cells one year after transplantation to rotenone-induced hemiparkinsonian rats. [Biol Blood Marrow Transplant]

Regulation of Mesenchymal Stem Cell Activity by Endothelial Cells
Researchers have determined the effects of paracrine factors secreted by human umbilical vein endothelial cells (HUVEC) on mesenchymal stem cell survival, proliferation and differentiation by using an optimised, serum-free HUVEC-conditioned medium. [Stem Cells Dev]

Glial Cell Line-Derived Neurotrophic Factor-Secreting Genetically Modified Human Bone Marrow-Derived Mesenchymal Stem Cells Promote Recovery in a Rat Model of Parkinson’s Disease
Here, researchers report the effects of glial cell line-derived neurotrophic factor-releasing Notch-induced human bone marrow-derived mesenchymal stem cells grafted into striatum of the 6-hydroxydopamine progressively lesioned rat model of Parkinson’s disease. [J Neurosci Res]

Circulating Plastic Adherent Mesenchymal Stem Cells in Aged Hip Fracture Patients
This initial study indicates mobilization of mesenchymal stem cells (MSCs) into the circulation in response to fracture, even in very old patients, while circulating MSCs were not detectable before or after elective total hip arthroplasty. [J Orthop Res]

Biocomposites Electrospun with Poly(Epsilon-Caprolactone) and Silk Fibroin Powder for Biomedical Applications
Researchers fabricated a biocomposite using poly(epsilon-caprolactone) and silk fibroin powder, which has good biocompatibility and mechanical properties. The biocompatibility of the biocomposite was evaluated in a culture of bone-marrow-derived rat mesenchymal stem cells. [J Biomater Sci Polym Ed]

Conditioned Media Enhance Osteogenic Differentiation on Poly(L-lactide-co-epsilon-caprolactone)/Hydroxyapatite Scaffolds and Chondrogenic Differentiation in Alginate
The objectives of this study were to determine the effects of chondrocyte conditioned medium (CM) on the osteogenic differentiation of mesenchymal stem cells (MSCs) cultured on poly(L-lactide-co-epsilon-caprolactone)/hydroxyapatite scaffolds and to determine the effect of osteoblast CM on the chondrogenic differentiation of MSCs cultured in alginate. [J Biomater Sci Polym Ed]

Safety Concern between Autologous Fat Graft, Mesenchymal Stem Cell and Osteosarcoma Recurrence
Researchers report a case of a late local recurrence of osteosarcoma which occurred 13 years after the initial pathology and 18 months after a lipofilling procedure. These observations and results raise the question of whether autologous fat grafting is a safe reconstructive procedure in a known post neoplasic context. [PLoS ONE]


INDUSTRY NEWS

Cytori Secures $20 Million Loan Facility Led by GE Capital, Healthcare Financial Services
Cytori Therapeutics entered into a $20 million secured loan facility from GE Capital, Healthcare Financial Services, Oxford Finance Corporation, and Silicon Valley Bank. [Cytori Therapeutics Press Release]

Vitro and HemoGenix(R) Launch New Products at an International Stem Cell Meeting
Vitro Diagnostics, Inc., dba Vitro Biopharma, and HemoGenix(R), Inc. announced the launch of new high performance stem cell testing products at the International Society for Stem Cell Research annual meeting being held in San Francisco. [The Wall Street Journal]


POLICY NEWS

FDA Takes Issue with Genetic Tests from 23andMe, Four Other Firms
The Food and Drug Administration has put five genetic test makers on notice that they must get federal approval before marketing their products for use by consumers. [Food and Drug Administration, United States]

NIH Chief Collins Faces Stem Cell Donation Dilemma
The NIH Advisory Committee to the Director, which advises NIH chief Francis Collins on whether lines meet the Obama ethics guidelines, faced the decision on whether 53 more stem cell lines should be added to that total. [National Institutes of Health, United States]

NIH Researchers Explore How Healthy, Young Adults View the Role Genetics Plays in Improving Health
Most healthy young adults place greater emphasis on health habits than on genetic risk factors when considering what causes common diseases, a research team from the National Human Genome Research Institute and the Henry Ford Health System in Detroit has found. [National Institutes of Health, United States]

Enhancing Peer Review: Advance Notice on Post-Submission Application Materials for NIH Training and Related Applications (NOT-OD-10-104) [National Institutes of Health, United States]

PFINDR: Phenotype Finder IN Data Resources: A Tool to Support Cross-Study Data Discovery Among NHLBI Genomic Studies (UH2/UH3) (RFA-HL-11-020) [National Institutes of Health, United States]

Clinical Trials for Medicines Section Updated [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Advertising and Supply of Therapeutic Goods to Complementary Healthcare Professionals: Schedule 1 to the Therapeutic Goods Regulations [Therapeutic Goods Administration, Australia]

Increased Transparency of the Prescription Medicine Regulatory Process [Therapeutic Goods Administration, Australia]


EVENTS

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

Worldwide Innovative Networking (WIN) Symposium in Personalized Cancer Medicine
July 7-9, 2010
Paris, France

Translational Cancer Medicine 2010 – USA
July 11-14, 2010
San Francisco, United State

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland


United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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