Volume 2.27 | Jul 13

Mesenchymal Cell News 2.27, July 13, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Platelet Derived Growth Factor (PDGF) – PDGF Receptor Interaction Activates Bone Marrow Derived Mesenchymal Stromal Cells Derived from Chronic Lymphocytic Leukemia: Implications for an Angiogenic Switch 
In this study, researchers observed that the conditioned medium obtained from chronic lymphocytic leukemic cells, was able to induce Akt activation in mesenchymal stromal cells. [Blood]

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SCIENCE NEWS

Mouse Stem Cell Study Offers New Insights into Body Fat Distribution
New research shows that adding fat to mouse stem cells grown in the lab affects their response to the signals that push them to develop into one or other of the main types of fat storage cells – subcutaneous (under the skin) or visceral (around the organs). [UK National Stem Cell Network Press Release]

New Cell Therapy Treatment for Osteoarthritis to be Trialled
Cultured stem cells are to be used for the first time in the UK to treat the common joint condition of osteoarthritis, throwing a potential lifeline to millions of sufferers in the future. [Robert Jones and Agnes Hunt Orthopaedic Hospital in Oswestry Press Release]

CAS_645x110_v01


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

EphB-Ephrin-B2 Interactions are Required for Thymus Migration During Organogenesis
Here, researchers show that, in the absence of ephrin-B2 expression on thymic neural crest-derived mesenchyme, the thymus remains in the cervical area instead of migrating into the thoracic cavity. [Proc Natl Acad Sci U S A]

Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates
To test the graft promoting effects of mesenchymal stem cells in a cynomolgus monkey model of islet/bone marrow transplantation. [Diabetes]

Biomimetic Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stem Cells to Neocartilage
This soft PEG/CMP hydrogel shows promise as a biomimetic scaffold that provides a desirable environment for the chondrogenic differentiation of human mesenchymal stem cells and is useful for the repair of cartilage defects. [Biomaterials]

The Effect of Incorporation of Exogenous Stromal Cell-Derived Factor-1 Alpha Within a Knitted Silk-Collagen Sponge Scaffold on Tendon Regeneration
This study developed a bioactive knitted silk-collagen sponge scaffold by incorporation of exogenous SDF-1 alpha, to enable selective migration and homing of cells for in situ tendon regeneration. [Biomaterials]

Characterizing Cancer Cells With Cancer Stem Cell-Like Features in 293T Human Embryonic Kidney Cells
Here, researchers fully characterize cancer stem cell-like features in 293T human embryonic kidney cells. [Mol Cancer]

Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis
Cannabinoids are derivates of the marijuana component delta(9)-tetrahydrocannabinol that exert their effects on mesenchymal cells and immune cells via CB1 and CB2 receptors. The aim of the present study was to evaluate the role of CB1 in systemic sclerosis. [Arthritis Rheum]

Control of Fibroblast Fibronectin Expression and Alternative Splicing Via the PI3K/Akt/mTOR Pathway
Here, researchers show TGF-beta, a potent inducer of both EDA (extra type III domain A) splicing and fibroblast activation, inhibits phosphatase and tensin homologue on chromosome 10 (PTEN) expression and activity in mesenchymal cells, corresponding with enhanced PI3K/Akt signaling. [Exp Cell Res]

Identification of Growth and Attachment Factors for the Serum-Free Isolation and Expansion of Human Mesenchymal Stromal Cells
Using classical approaches of medium development, researchers were able to identify a set of growth and attachment factors that allowed the serum-free isolation and expansion of human mesenchymal stromal cells from bone marrow. [Cytotherapy]


INDUSTRY NEWS

NeoStem to Receive $700,000 from the U.S. Army’s Medical Research and Materiel Command to Advance Adult Stem Cell Therapies in Treating Traumatic Wounds
NeoStem, Inc. announced that it has been awarded a $700,000 contract from the U.S. Army Medical Research and Materiel Command, Telemedicine and Advanced Technology Research Center under U.S. Army Medical Research Acquisition Activity contract number: (W81XWH-10-2-0039). [NeoStem, Inc. Press Release]

White House’s Medicare Pick To Be Installed
President Barack Obama plans to install his nominee to oversee Medicare and Medicaid, using a tactic aimed at averting a bitter fight in Congress. [The Wall Street Journal]


POLICY NEWS

Harold Varmus Sworn in as National Cancer Institute’s 14th Director
Nobel Prize winner Harold E. Varmus, M.D., today took the oath of office to become the National Cancer Institute’s (NCI) 14th director. NCI is one of the 27 Institutes and Centers that comprise the National Institutes of Health (NIH). [National Institutes of Health, United States]

Britain Delays Controversial Assessment Scheme for Research
Britain’s new science minister made good a manifesto pledge today when he announced that the coalition government would delay for one year the implementation of the controversial Research Excellence Framework, a system of assessing university departments for the distribution of funding. [Ministry of Universities and Science, United Kingdom]

Spanish Science Spending Lockdown
Spain’s science and innovation minister said that research funding will be “frozen or minimally reduced” as a result of government-wide austerity measures. [Ministry of Science and Innovation, Spain]

Maryland Stem Cell Research Commission Elects Margaret Conn Himelfarb as Chair
The Maryland Stem Cell Research Commission announced that it has elected Margaret Conn Himelfarb as chair and Bowen P. Weisheit, Jr. as vice chair. [Maryland Stem Cell Research Commission, United States]

Clinical Laboratory Improvement Advisory Committee (CLIAC); Notice of Meeting
[Centers for Disease Control and Prevention, United States]

Request for Information (RFI) on the National Institutes of Health Plan to Develop the Genetic Testing Registry; Notice [National Institutes of Health, United States]

Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting [National Institutes of Health, United States]

Advisory Committee on Organ Transplantation; Notice of Meeting [National Institutes of Health, United States]


EVENTS

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland


United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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