Volume 2.29 | Jul 27

Mesenchymal Cell News 2.29, July 27, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Study Suggests Link Between Metabolic Disease, Bone Mass in Mice
A new study found that insulin is required for normal bone development and that it may provide a link between bone health and metabolic disease, such as diabetes. [Press release from John Hopkins University discussing online publication in Cell

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SCIENCE NEWS

Study Ties Abnormal Cells in Blood to Lung Cancer
A novel approach detects genetically abnormal cells in the blood of non-small cell lung cancer patients that match abnormalities found in tumor cells and increase in number with the severity of the disease. [Press release from the University of Texas M.D. Anderson Cancer Center discussing online prepublication in Clinical Cancer Research]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
Investigators show that insulin receptor signaling in osteoblasts controls osteoblast development and osteocalcin expression by suppressing the Runx2 inhibitor Twist2. [Cell]

Genetically Abnormal Circulating Cells in Lung Cancer Patients: An Antigen-Independent Fluorescence In Situ Hybridization-Based Case-Control Study 
Researchers performed a study to determine if a fluorescence in situ hybridization-based assay using isolated peripheral blood mononuclear cells with DNA probes targeting specific sites on chromosomes known to have abnormalities in non-small cell lung cancer cases could detect circulating genetically abnormal cells. [Clin Cancer Res]

A Therapeutic Strategy for Choroidal Neovascularization Based on Recruitment of Mesenchymal Stem Cells to the Sites of Lesions
Scientists found that bone marrow-derived mesenchymal stem cells transplanted by intravenous injection into laser-induced choroidal neovascularization (CNV) mouse models were specifically recruited into CNV lesions, where they differentiated into multiple cell types and participated in the development of neovascularization, without stagnation in other organs. [Mol Ther]

Short Bouts of Mechanical Loading are as Effective as Dexamethasone at Inducing Matrix Production by Human Bone Marrow Mesenchymal Stem Cell
The goal of this study was to investigate the effects of dynamic compressive loading on differentiation and mineralized matrix production of human mesenchymal stem cells in 3D polyurethane scaffolds, using a loading regimen previously shown to stimulate mineralized matrix production of mature bone cells. [Eur Cell Mater]

Biological Safety of Human Skin-Derived Stem Cells After Long-Term In Vitro Culture
Researchers aimed to investigate the biological safety of human skin-derived mesenchymal stem cells cultured in vitro by detecting changes in karyotype, major histocompatibility complex expression and tumorigenicity. [J Tissue Eng Regen Med]

Chondrogenic Differentiation of Human Mesenchymal Stem Cells in Micro-Masses is Impaired by High Doses of the Chemokine CXCL7
The aim was to analyse the effect of CXCL7, a chemokine that has the capacity to recruit mesenchymal stem cells (MSCs), on the chondrogenic differentiation of MSCs. [J Tissue Eng Regen Med]

Activation of Nervous System Development Genes in Bone Marrow Derived Mesenchymal Stem Cells Following Space Flight Exposure
Having overcome technological difficulties associated with flying cells in a space mission, researchers presented the first report on the behavior of the potentially osteogenic murine bone marrow stromal cells in a 3D culture system, flown inside the KUBIK aboard space mission ISS 12S from 30 March to 8 April 2006. [J Cell Biochem]

Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes
In this study, researchers analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells derived from human synovial membranes enriched for CD73, CD106 and CD271 markers. [J Cell Biochem]

Luciferase Labeling for Multipotent Stromal Cell Tracking in Spinal Fusion Versus Ectopic Bone Tissue Engineering in Mice and Rats
Researchers investigated cell proliferation around the spine and at ectopic sites using noninvasive in vivo bioluminescence imaging in relation to new bone formation. [Tissue Eng Part A]



INDUSTRY NEWS

Mesoblast Receives TGA Regulatory Approval to Commercially Manufacture Adult Stem Cell Products
Mesoblast Limited announced that the Australian Therapeutic Goods Administration (TGA) has issued a license to Mesoblast to manufacture and supply its proprietary Mesenchymal Precursor Cell products. [Mesoblast Limited Press Release]

Prochymal New Drug Submission Granted Priority Review by Health Canada
Osiris Therapeutics, Inc. announced that the Biologics and Genetic Therapies Directorate of Health Canada has completed its initial evaluation and accepted for full review the company’s New Drug Submission of Prochymal, an adult stem cell therapy for the treatment of graft vs. host disease. [Press Release from Osiris Therapeutics Inc.]

Beike Biotechnology Opens First Chinese Rehabilitation Center in Romania
Beike Biotechnology Co. Ltd. opened Romania’s first rehabilitation center to use traditional Chinese-style rehabilitation techniques in Campina today. [Beike Biotech Co. Ltd Press Release]

BrainStorm Retains Life Sciences Advisory Firm
BrainStorm Cell Therapeutics Inc. announced that it has retained MD Becker Partners LLC, a boutique management and strategy consulting firm focusing on both public and private companies in the life sciences industry. [Press Release from BrainStorm Cell Therapeutics Inc.]



POLICY NEWS

Brussels to Invest $8.3 Billion in Research
Research organizations, universities, and industry will receive a sum of EUR6.4 billion next year in the European Commission’s largest ever allocation for research and innovation. [European Commission, European Union]

NIH Asks for Input on Closing Loophole in Conflict-of-Interest Rule
Responding to yet another flap about the influence of drug companies on biomedical research, the National Institutes of Health (NIH) has decided it needs more time to revise its rules for policing conflicts of interest so that sanctions will move with an investigator if he or she changes institutions. [National Institutes of Health, United States]

NIH Director Announces Appointment of Alan Guttmacher as Director of NICHD
National Institutes of Health Director Francis S. Collins M.D., Ph.D., announced today the appointment of Alan E. Guttmacher, M.D., as director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [National Institutes of Health, United States]

National Institute of General Medical Sciences; Notice of Closed Meeting (Doc. 2010-18088) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (Doc. 2010-18052) [National Institutes of Health, United States]

Instrument Development for Biomedical Applications (R21) (RFA-RR-10-009) [National Institutes of Health, United States]

Biosafety in Microbiological and Biomedical Laboratories (BMBL): 5th Edition (NOT-OD-10-117) [National Institutes of Health, United States]

Bioengineering Research Partnerships (BRP)[R01] (PAR-10-234) [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering Program Project (P01) Applications (PAR-10-233) [National Institutes of Health, United States]

Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health Service Funding Is Sought and Responsible Prospective Contractors [Docket Number NIH-2010-0001] [Department of Health and Human Services, United States]



EVENTS (Listed by Date)

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland


International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

NEW 5th Annual Germany Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

NEW International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
January 21-26, 2011
Vancouver, Canada

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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