Volume 2.31 | Aug 10


TOP STORY

Rb Regulates Fate Choice and Lineage Commitment In Vivo  ShareThis
Because osteoblasts and adipocytes can both arise from mesenchymal stem cells, observations suggest that pRb might play a role in the choice between these two fates. However, so far, there is no evidence for this in vivo . Here researchers used mouse models to address this hypothesis in mesenchymal tissue development and tumorigenesis. [Nature]

mTeSR  
Derive iPSCs feeder-free* with mTeSR®1
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*Sun et al., PNAS, September 2009.
*Chan et al., Nature Biotechnology, October 2009.
STEMCELL Technologies Inc
 




SCIENCE NEWS

Newts’ Ability to Regenerate Tissue Replicated in Mouse Cells by Scientists
Scientists have taken a big step toward being able to confer newts’ regenerative capacity on mammalian muscle cells; they accomplished this feat in experiments with laboratory mice in which they blocked the expression of just two tumor-suppressing proteins. [Press release from Stanford University discussing online prepublication in Cell Stem Cell]

New Insights into How Stem Cells Determine What Tissue to Become
Within 24 hours of culturing adult human stem cells on a new type of matrix, researchers were able to make predictions about how the cells would differentiate, or what type of tissue they would become. [Press release from the University of Michigan discussing online prepublication in Nature Methods]

MesenCult®-XF Medium  
Culture Human Mesenchymal Stem Cells in
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by STEMCELL Technologies
 
 
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle
The study’s results show that differentiation of mammalian cells is reversed by inactivation of Arf and Rb and supported the hypothesis that Arf evolved at the expense of regeneration. [Cell Stem Cell]

Mechanical Regulation of Cell Function with Geometrically Modulated Elastomeric Substrates
Scientists reported the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. [Nat Methods]

Bone Marrow Mesenchymal Stem Cells Stimulate Cardiac Stem Cell Proliferation and Differentiation
Here, researchers tested the hypothesis that bone marrow derived mesenchymal stem cells stimulate the proliferation and differentiation of endogenous cardiac stem cells as part of their regenerative repertoire. [Circ Res]

The Role of Biomaterials in the Direction of Mesenchymal Stem Cell Properties and Extracellular Matrix Remodeling in Dermal Tissue Engineering
This study compared the epithelial-mesenchymal interaction and extracellular matrix remodeling of cell-based and collagen-based dermal equivalents using fibroblasts, human mesenchymal stem cells from bone marrow or Wharton’s Jelly of the umbilical cord, respectively, in co-culture with the keratinocyte cell line HaCaT. [Biomaterials]

The BRG1 ATPase of Chromatin Remodeling Complexes is Involved in Modulation of Mesenchymal Stem Cell Senescence Through RB-P53 Pathways
Investigators focused their attention on brahma-related gene 1, the ATPase subunit of the SWItch/Sucrose NonFermentable chromatin remodeling complex, and analyzed its role in mesenchymal stem cell biology. [Oncogene]

Proteome Analysis of Rat Bone Marrow Mesenchymal Stem Cell Differentiation
This study was designed to investigate the protein expression profiles of rat bone marrow mesenchymal stem cells during differentiation into adipogenic (by dexamethasone, isobutylmethylxanthine, insulin and indomethacin), cardiomyogenic (by 5-azacytidine), chondrogenic (by ascorbic acid, insulin-transferrin-selenous acid, and transforming growth factor-beta 1) and osteogenic (by dexamethasone, beta-glycerophosphate, and ascorbic acid) lineages by well-known differentiation inducers. [J Proteome Res]

Tissue-Resident Mesenchymal Stem Cells Attract Peripheral Blood Neutrophils and Enhance Their Inflammatory Activity in Response to Microbial Challenge
Scientists hypothesized that tissue-specific mesenchymal stem cells (MSCs) could play an instructional role during early phases of bacterial challenge. To investigate this hypothesis further, scientists set up a coculture system of glandular MSCs and peripheral blood neutrophils so that they could analyze the cellular interactions of these cells in response to LPS challenge. [J Leukoc Biol]

Oxygen Tension Differentially Regulates the Functional Properties of Cartilaginous Tissues Engineered from Infrapatellar Fat Pad Derived MSCs and Articular Chondrocytes
The objective of this study was to investigate how chondrocytes and infrapatellar fad pad derived mesenchymal stem cells will respond to a low oxygen (5%) environment in 3D agarose culture. The hypothesis was that culture in a low oxygen environment (5%) will enhance the functional properties of cartilaginous tissues engineered using both cell sources. [Osteoarthristis Cartilage]




INDUSTRY NEWS

Osiris Therapeutics Reports Second Quarter 2010 Financial Results
Osiris Therapeutics, Inc. announced its results for the second quarter of fiscal 2010. [Osiris Therapeutics, Inc. Press Release]

Free Access to U.S. Research Papers Could Yield $1 Billion in Benefits
A new economic analysis finds that making taxpayer-funded scientific papers freely available would yield more than $1 billion in benefits to the U.S. economy over 30 years-five times the costs of archiving the papers. [ScienceInsider]




POLICY NEWS

Scientists Decry Proposed Ban on Chimp Research
In the latest twist in the protracted debate over the use of chimpanzees in biomedical research, U.S. senators introduced the Great Ape Protection Act, an identical bill to one that has been stuck in a House of Representatives committee for more than a year. [Senate, United States]

FDA Seeks Injunction Against Colorado Manufacturer of Cultured Cell Product
The U.S. Food and Drug Administration is seeking an injunction in federal court against Regenerative Sciences LLC, citing violations of current good manufacturing practice that cause its cultured cell product to be adulterated. [US Food and Drug Administration, United States]

Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Administrative Procedures for the Clinical Laboratory Improvement Amendments of 1988 Categorization [Docket No. FDA-2010-N-0199] [Food and Drug Administration, United States]

Clinical Studies of Safety and Effectiveness of Orphan Products Research Project Grant (R01) [Docket No. FDA-2010-N-0394] [Food and Drug Administration, United States]

Solicitation for Nominations: New Clinical Preventive Health for the United States Preventive Services Task Force, [2010-19117] [Agency for Healthcare Research and Quality, United States]

Technical Assistance Videocast for RFA-RR-10-007: Clinical and Translational Science Coordinating Center (U54) (NOT-RR-10-012) [National Institutes of Health, United States]

NIH Common Fund Transformative Research Projects Program (R01) (RFA-RM-10-010) [National Institutes of Health, United States]

Chimpanzee Biomedical Research Program Limited Competition (U42) (RFA-RR-10-008) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-19167) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Meeting (FR Doc. 2010-19165) [National Institutes of Health, United States]

2010 Biological License Application Approvals  [Center for Biologics Evaluation and Research, United States]

2010 Biological License Application Supplement Noteworthy Approvals [Center for Biologics Evaluation and Research, United States]

2010 Biological Device Application Approvals  [Center for Biologics Evaluation and Research, United States]




EVENTS (Listed by Date)

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland


International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

NEW Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States   

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Germany Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

NEW
17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

bone-tec 2010 – International Bone-Tissue Engineering Congress
October 7-10, 2010
Hannover, Germany

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

NEW Stem Cell Society Singapore Symposium 2010
November 2-3, 2010
Singapore

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
January 21-26, 2011
Vancouver, Canada

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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