Volume 2.32 | Aug 17



TOP STORY

Researchers Discover that One Type of Stem Cell Creates a Niche for Another Type Within Bone Marrow  ShareThis
Collaborators reported that the hematopoietic stem cells (HSCs) retain their unique features in response to signals from another stem cell population, the mesenchymal stem cells, which creates a supportive bone marrow niche for the HSCs. [Press release from Cold Spring Harbor Laboratory discussing online prepublication in Nature]

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SCIENCE NEWS

Mayo’s “Smart” Adult Stem Cells Repair Hearts
Mayo Clinic investigators, with Belgian collaborators, have demonstrated that rationally “guided” human adult stem cells can effectively heal, repair and regenerate damaged heart tissue. [Press release from Mayo Clinic discussing online prepublication in the Journal of the American College of Cardiology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Mesenchymal and Hematopoietic Stem Cells Form a Unique Bone Marrow Niche
Here researchers demonstrated that mesenchymal stem cells, identified using nestin expression, constitute an essential hematopoietic stem cells niche component. [Nature]

Guided Cardiopoiesis Enhances Therapeutic Benefit of Bone Marrow Human Mesenchymal Stem Cells in Chronic Myocardial Infarction
The goal of this study was to guide bone marrow-derived human mesenchymal stem cells into a cardiac progenitor phenotype and assess therapeutic benefit in chronic myocardial infarction. [J Am Coll Cardiol]

Bone Marrow-Derived Mesenchymal Cells and MMP13 Contribute to Experimental Choroidal Neovascularization
In this study, investigators evaluated the potential involvement of collagenase-3 (MMP13), a matrix metalloproteinase family member, in the exudative form of age-related macular degeneration characterized by a neovascularisation into the choroid. [Cell Mol Life Sci]

Down-Regulation of Thrombomodulin, a Novel Target of Snail, Induces Tumorigenesis Through Epithelial-Mesenchymal Transition
The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently down-regulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown. Here, an inverse expression of TM and Snail was detected in different cancer cell lines. [Mol Cell Biol]

Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Via Upregulation of Kruppel-Like Factor 2
This study shows that ultraviolet A inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells and its action mechanisms. [J Biol Chem]

Effects of Microgravity Modeled by Large Gradient High Magnetic Field on the Osteogenic Initiation of Human Mesenchymal Stem Cells
In the present study, scientists used large gradient high magnetic field (LGHMF) produced by a superconducting magnet to model microgravity (LGHMF-MG) and analyzed the effects of LGHMF-MG on survival, cytoskeleton and osteogenic potential of human mesenchymal stem cells. [Stem Cell Rev]

Isolation of Cancer Stem Cells from Transformed Human Mesenchymal Stem Cell Line F6
In the present study, scientists isolated cancer stem cells from F6 cells based on CD133 expression using flow cytometry and investigated the biological characteristics of CD133+ F6 cells. [J Mol Med]

Culture and Differentiation of Osteoblasts on Coral Scaffold from Human Bone Marrow Mesenchymal Stem Cells
In this paper investigators described an approach that aims to provide fundamental information towards a scientific, biomechanical basis for the use of natural coral scaffolds to initiate mesenchymal stem cells into osteogenic differentiation for transplant purposes. [Cell Tissue Bank]




INDUSTRY NEWS

Mesoblast On Track For Phase 3 Bone Marrow Transplant Trial Following Positive Meeting With FDA
Mesoblast Limited provided market guidance on its Phase 3 bone marrow transplant program following a formal meeting with the United States Food and Drug Administration (FDA). [Mesoblast Limited Press Release]

Cytori Issued Celution(R) System Patent for Orthopedic & Spinal Disc Diseases
Cytori Therapeutics has received U.S. Patent No. 7,771,716 (the ‘716 patent) for Celution(R) System based methods of treating musculoskeletal disorders such as spinal disc disease. [Cytori Therapeutics Press Release]

NeoStem Provides Second Quarter Update
NeoStem Inc. is providing results of its second quarter 2010. [NeoStem Inc. Press Release]

Cardio3 BioSciences Publishes the Science Basis for C-Cure(R) in JACC
Cardio3 BioSciences, a leading Belgian biotechnology company specializing in regenerative therapies for the treatment of cardiovascular disease, announced the key scientific work underlying its lead pharmaceutical product C-Cure(R), a revolutionary stem cell treatment for heart failure, has been published. [Cardio3 Biosciences Press Release]




POLICY NEWS

EU Agency Allows Access to Drug Side Effects Data
The European Medicines Agency has agreed to provide access to studies about drug side effects, following criticism over data secrecy from the European Ombudsman. [European Medicines Agency, European Union]

Scientists Receive Nearly $11 Million to Develop Radiation Countermeasures
Scientists at Albert Einstein College of Medicine of Yeshiva University have received a five-year, $10.8 million grant to develop stem cell-based therapies that could be used to mitigate radiation-induced gastrointestinal syndrome – part of acute radiation syndrome – for military personnel, first responders and the general public. [National Institute of Allergy and Infectious Diseases, United States]

Proposed Collection; Comment Request; NIH NCI Central Institutional Review Board (CIRB) Initiative (NCI) (FR Doc. 2010-20167) [National Institutes of Health, United States]

Center for Scientific Review, Notice of Closed Meetings (FR Doc. 2010- 20023) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Meeting (FR Doc. 2010-20014) [National Institutes of Health, United States]

7342.007 Addendum – Imported Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps)  [Center for Biologics Evaluation and Research, United States]

7342.007 – Imported CBER-Regulated Products [Center for Biologics Evaluation and Research, United States]

Complete List of Licensed Products and Establishments [Center for Biologics Evaluation and Research, United States]

Comprehensive List of Guidance Documents at the Food and Drug Administration [Docket No. FDA-1998-N-0050] (formerly Docket No. 1998N-0046) [Food and Drug Administration, United States




EVENTS (Listed by Date)

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland


International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States   

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Germany Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

bone-tec 2010 – International Bone-Tissue Engineering Congress
October 7-10, 2010
Hannover, Germany

NEW The NYSCF Fifth Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York, United States

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

Stem Cell Society Singapore Symposium 2010
November 2-3, 2010
Singapore

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
January 21-26, 2011
Vancouver, Canada

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

NEW Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Keystone, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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