Volume 2.35 | Sep 7

Mesenchymal Cell News 2.35, September 7, 2010.
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Umbilical Cord-Derived Mesenchymal Stem Cells Isolated by a Novel Explantation Technique Can Differentiate into Functional Endothelial Cells and Promote Revascularization 
Researchers report on the development of a simple and effective protocol to isolate umbilical cord-derived mesenchymal stem cells, and confirm their endothelial potential both in vitro and in vivo. [Stem Cells Dev]



How Physical Environment Influences Stem Cell Development
Recent research has revealed how physical qualities — and not only chemical ones — may have an influence in determining how adult stem cells from the bone marrow develop into differentiated ones. [Press release from ScienceDaily discussing online prepublication in Nature Physics]

New Evidence that Fat Cells Are not Just Dormant Storage Depots for Calories
Scientists are reporting new evidence that the fat tissue in those spare tires and lower belly pooches — far from being a dormant storage depot for surplus calories — is an active organ that sends chemical signals to other parts of the body, perhaps increasing the risk of heart attacks, cancer, and other diseases. [Press release from the American Chemical Society discussing online prepublication in the Journal of Proteome Research]

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Obtain more MSCs in fewer passages with
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Puma is Required for p53-Induced Depletion of Adult Stem Cells
To investigate the roles of DNA damage and p53 in tissue-regenerative capability, two phosphorylation-site mutations (T21D and S23D) were introduced into the endogenous p53 gene in mice, so that the synthesized protein mimics phosphorylated p53. [Nat Cell Biol]

Optimal Matrix Rigidity for Stress-Fiber Polarization in Stem Cells
The findings offer physical insight into the sensitivity of stem cell differentiation to tissue elasticity and, more generally, introduce a cell-type-specific parameter for actomyosin polarizability. [Nat Phys]

Tuberin Regulates E-Cadherin Localization – Implications in Epithelial-Mesenchymal Transition
In this study, researchers show that tuberin regulates the localization of E-cadherin via an Akt/mTORC1/CLIP170-dependent, rapamycin-sensitive pathway. Consequently, Tsc2(-/-) epithelial cells display a loss of plasma membrane E-cadherin that leads to reduced cell-cell adhesion. [Am J Pathol]

Identification of Novel Human Adipocyte Secreted Proteins by Using SGBS Cells
It can be concluded that Simpson Golabi Behmel syndrome (SGBS) cells are both a valid human cell model for adipocyte secretion profiling and for searching for novel human (pre)adipocytes secreted proteins. [J Proteome Res]

New Strategies for Anterior Cruciate Ligament Partial Rupture Using Bone Marrow Transplantation in Rats
The purpose of this study was to compare anterior cruciate ligament regeneration between animal groups subjected to intra-articular injection of fresh whole bone marrow cells, cultured mesenchymal stem cells or saline. [Stem Cells Dev]

Hypoxia and Amino Acid Supplementation Synergistically Promote the Osteogenesis of Human Mesenchymal Stem Cells on Silk Protein Scaffolds
Silk protein scaffolds seeded with human mesenchymal stem cells in osteogenic differentiation media were used to study in vitro osteogenesis under varied conditions of amino acid (lysine and proline) concentration and oxygen level. [Tissue Eng Part A]

The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics Study
The goal of this study was to evaluate the effect of simulated microgravity on all genes expressed in human mesenchymal stem cells, with the underlying hypothesis that many important pathways are affected during culture within a rotating wall vessel system. [Tissue Eng Part A]

Improved Proliferation and Differentiation Capacity of Human Mesenchymal Stromal Cells Cultured with Basement-Membrane Extracellular Matrix Proteins
The results suggest that expansion of bone marrow-derived mesenchymal stromal cells (MSC) in the presence of extracellular matrix proteins is a powerful approach for generating large numbers of MSC, showing a prolonged capacity to differentiate into mesodermal cell lineages, with the exception of the lack of chondrogenesis by using laminin-5 coating. [Cytotherapy]


Health Experts Warn of “Stem Cell Tourism” Dangers
Thousands of people are putting their health and life savings at risk to travel to private clinics around the world for unproven and potentially dangerous stem cell treatments, British experts said. [Reuters]


NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research
Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States]

Obama Administration Appeals Stem Cell Injunction
The Obama administration asked a federal judge on to lift an injunction halting human embryonic stem cell research, saying it would irreparably harm research and cost more than 1,300 jobs. [The White House, United States]

NIH Asks Judge to Suspend Stem Cell Research Injunction
Warning of a “devastating impact” on ongoing research, the National Institutes of Health (NIH) asked a federal court to stay a preliminary injunction that last week forced NIH to suspend future grant payments to study human embryonic stem cells (hESC) and shut down its in-house research on hESCs. [National Institutes of Health, United States]

Judge Upholds Stem Cell Funding Ban
A Washington, D.C., judge said this afternoon that his ruling two weeks ago, halting all federal funding for human embryonic stem cell research, will stand while the case moves forward. Chief Judge Royce Lamberth, responding to a request from the Department of Justice that he stay his preliminary injunction, released a 3-page order denying the request. [United States District Court for the District of Columbia]

Medical School Leaders Express Support for Stem Cell Research in New AAMC Ad [Association of American Medical Colleges, United States]

Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

Findings of Research Misconduct (NOT-OD-10-132) [Department of Health and Human Services, United States]

Protein Structure Initiative:Biology-Materials Repository (PSI:Biology-MR) (U01) (RFA-GM-11-008) [National Institute of General Medical Sciences, United States]

Developing and Improving Institutional Animal Resources (G20) (RFA-RR-10-011) [National Center for Research Resources, United States]

EVENTS (Listed by Date)

International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States   

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Germany Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

bone-tec 2010 – International Bone-Tissue Engineering Congress
October 7-10, 2010
Hannover, Germany

The NYSCF Fifth Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York, United States

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

Stem Cell Society Singapore Symposium 2010
November 2-3, 2010

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
January 21-26, 2011
Vancouver, Canada

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Keystone, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Cell Therapy Technologist (Opexa Therapeutics)

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