Volume 2.36 | Sep 14

Mesenchymal Cell News 2.36, September 14, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

C-Kit+ Cardiac Progenitors Exhibit Mesenchymal Markers and Preferential Cardiovascular Commitment 
In line with previous findings, the results indicate c-kit+ cardiac progenitor cells as primitive stem cells endowed with multilineage differentiation ability. They further suggest a possible relationship between these cells and a heart-specific mesenchymal stem cell population with cardiovascular commitment potential. [Cardiovasc Res]

MesenCult®-XF Medium  
Culture Human Mesenchymal Stem Cells in
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SCIENCE NEWS

A Smart Use for Wisdom Teeth: Making Stem Cells
For most people, wisdom teeth are not much more than an annoyance that eventually needs to be removed. However, a new study shows that wisdom teeth contain a valuable reservoir of tissue for the creation of stem cells; thus, everyone might be carrying around his or her own personal stem cell repository should he or she ever need some. [Press release from EurekAlert! discussing online prepublication to be published in the Journal of Biological Chemistry]

mTeSR  
Derive iPSCs feeder-free* with mTeSR®1
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*Sun et al., PNAS, September 2009.
*Chan et al., Nature Biotechnology, October 2009.
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Periodontal Regeneration Using Engineered Bone Marrow Mesenchymal Stromal Cells
Researchers hypothesized that bone marrow mesenchymal stromal cells are able to sense biological cues from the local microenvironment and organize appropriately to contribute to the regeneration of both soft and hard periodontal connective tissues. [Biomaterials]

Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model
The findings suggest that paracrine factors derived from multipotent stromal cells is the main mechanism for the protection of lung tissues from elastase injury. [Mol Ther]

Human Cardiac and Bone Marrow Stromal Cells Exhibit Distinctive Properties Related to Their Origin
Objective of the present work is the comparison of in vitro and in vivo properties of adult human cardiac stromal cells to those of syngeneic bone marrow mesenchymal stromal cells. [Cardiovasc Res]

Mesenchymal Stem Cells Stimulate Endogenous Neurogenesis in the Subventricular Zone of Adult Mice
This is the first study to show that mesenchymal stem cells might interfere with the tight regulation of the subgranular zone, independent of the induced brain lesion. [Stem Cell Rev]

Atorvastatin Prevents Mesenchymal Stem Cells from Hypoxia and Serum-Free Injury Through Activating AMP-Activated Protein Kinase
Researchers hypothesized that atorvastatin could protect mesenchymal stem cells from hypoxia and serum-free injury through AMP-activated protein kinase-endothelial nitric oxide synthase pathway. [Int J Cardiol]

Mesenchymal Stem Cells Display Hepato-Protective Activity in Lymphoma Bearing Xenografts
The data suggest that hyaluronan-embedded mesenchymal stem cells exert anti-lymphoma activity by ameliorating hepatic functionality. [Invest New Drugs]

Anti-Fibrotic Effect of Chorionic Plate-Derived Mesenchymal Stem Cells Isolated from Human Placenta in a Rat Model of CCl4-Injured Liver: Potential Application to the Treatment of Hepatic Diseases
Here, researchers evaluated the therapeutic effect of chorionic plate-derived mesenchymal stem cells isolated from human placenta and transplanted into rats with carbon tetrachloride (CCl4)-injured livers. [J Cell Biochem]

Maintenance and Expansion of Hematopoietic Stem/Progenitor Cells in Biomimetic Osteoblast Niche
In this study, researchers employed bio-derived bone scaffold and composited with the marrow mesenchymal stem cell induced into osteoblast to replicate a “biomimetic niche”. [Cytotechnology]

INDUSTRY NEWS

STEMSOFT® Software Inc. Licenses StemLab® Software to Arizona’s Celebration Stem Cell Centre
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the licensing of StemLab, the leading cell therapy and cord blood banking laboratory software, to the Celebration Stem Cell Centre in Gilbert, Arizona. [STEMSOFT Software Inc. Press Release]

AstraZeneca and UCL Join Forces in Sight-Related Stem Cell Medicine
AstraZeneca and University College London (UCL) have entered into a collaboration to develop regenerative medicines for diabetic retinopathy. [University College London Press Release]

Forbion Capital Partners Raises EUR190 Million for New Investments
Forbion Capital Partners, a leading investment firm dedicated to the life science sector, announced the final closings of both FCF I Co-Invest Fund and of FCF II, raising a total of more than EUR190 million ($240 million). [Forbion Capital Partners Press Release]

NIH Awards $8 Million to UT Southwestern to Study Metabolism, Obesity-Related Inflammation
An $8 million grant from the National Institutes of Health will enable UT Southwestern Medical Center to investigate how fat tissue “talks” to the brain and the liver to promote inflammation-related disorders such as diabetes, heart disease and obesity. [UT Southwestern Medical Center Press Release]

Lilly to Invest Up to $150 Million in Venture Capital
Eli Lilly & Co., facing competition from cheaper copies of its top-selling drug next year, plans to invest as much as $150 million in three venture capital funds to aid development of new medicines. [Bloomberg]


POLICY NEWS

NIH Expands Network Focused on How Genes Affect Drug Responses [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327) [National Institutes of Health, United States]

National Heart, Lung, and Blood Institute; Notice of Closed Meeting (FR Doc. 2010-22314) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meetings (FR Doc. 2010-22529) [National Institutes of Health, United States]

Notice of Correction:  Application Due Date for RFA-HG-10-012, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R01) and RFA-HG-10-013, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R21) (Notice Number:NOT-HG-10-021) [National Institutes of Health, United States]

Knockout Mouse Production and Cryopreservation (U42) (RFA-RM-10-013) [National Institutes of Health, United States]

Knockout Mouse Phenotyping Project Database (U54) (RFA-RM-10-012) [National Institutes of Health, United States]

Knockout Mouse Phenotyping (U54) (RFA-RM-10-011) [National Institutes of Health, United States]

Enhancing Peer Review:  Reminder of and Correction to Previous Notice on A2 Resubmission Opportunities for Eligible Applications (NOT-OD-10-135) [National Institutes of Health, United States]

Notice of Correction to RFA-AG-11-010, Basic Research on Self-Regulation (R21) (NOT-AG-10-011) [National Institutes of Health, United States]

Agenda for the Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations [Food and Drug Administration, United States]


EVENTS (Listed by Date)

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Germany Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

bone-tec 2010 – International Bone-Tissue Engineering Congress
October 7-10, 2010
Hannover, Germany

The NYSCF Fifth Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York, United States

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

Stem Cell Society Singapore Symposium 2010
November 2-3, 2010
Singapore

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
January 21-26, 2011
Vancouver, Canada

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Keystone, United States

NEW  Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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