Volume 2.42 | Oct 26

Mesenchymal Cell News 2.42, October 26, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Age-Related Changes in Mesenchymal Stem Cells Derived from Rhesus Macaque Bone Marrow 
This study compared mesenchymal stem cells isolated from the bone marrow of rhesus monkeys (rBMSCs) in three age groups: young (<5 years), middle (8-10 years), and old (>12 years). The effects of aging on stem cell properties and indicators of stem cell fitness such as proliferation, differentiation, circadian rhythms, stress response proteins, miRNA expression, and global histone modifications in rBMSCs were analyzed. [Aging Cell]

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SCIENCE NEWS

ScienceShot: Exercise Boosts Muscle Stem Cells
Researchers found that the number of satellite cells increased after rats spent 13 weeks running on a treadmill for 20 minutes a day. [Press release from ScienceNow discussing online prepublication in PLoS ONE]

Defining Characteristics of Bona Fide Human iPS Cells
Speaker: Sutheera Ratanasirintrawoot, PhD Candidate
G. Daley & T. Schlaeger Labs, Harvard Medical School
WEBINAR: VIEW HERE STEMCELL Technologies Inc


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Glucocerebrosidase Gene-Deficient Mouse Recapitulates Gaucher Disease Displaying Cellular and Molecular Dysregulation Beyond the Macrophage
Researchers conditionally deleted the glucocerebrosidase gene in hematopoietic and mesenchymal cell lineages using an Mx1 promoter. [Proc Natl Acad Sci USA]

Mesenchymal Stem Cells or Cardiac Progenitors for Cardiac Repair? A Comparative Study
In this study, researchers performed a comparative study between human mesenchymal stem cells, purified c-kit+ cardiac stem cells, and cardiosphere-derived cells. [Cell Mol Life Sci]

Matrix Stiffness Regulation of Integrin-Mediated Mechanotransduction During Osteogenic Differentiation of Human Mesenchymal Stem Cells
Results provides evidence that matrix rigidity affects the osteogenic outcome of mesenchymal stem cells through mechano-transduction events that are mediated by alpha2 integrin. [J Bone Miner Res]

New Strategies for Anterior Cruciate Ligament Partial Rupture Using Bone Marrow Transplantation in Rats
The purpose of this study was to compare anterior cruciate ligament regeneration between animal groups subjected to intra-articular injection of fresh whole bone marrow cells, cultured mesenchymal stem cells, or saline. [Stem Cells Dev]

Regulation of Human Mesenchymal Stem Cell Functions by an Autocrine Loop Involving NAD+ Release and P2Y11-Mediated Signaling
In several cell types, a regulated efflux of NAD+ across Connexin 43 hemichannels (Cx43 HC) can occur and extracellular NAD+ (NAD+e) affects cell-specific functions. Researchers studied the capability of bone marrow-derived human mesenchymal stem cells to release intracellular NAD+ through Cx43-HC. [Stem Cells Dev]

Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise
Here, researchers focused on characterizing the effect of moderate-intensity endurance exercise on satellite cell, as possible means to attenuate adverse effects of aging. [PLoS ONE]

Correlation Between Compositional and Mechanical Properties of Human Mesenchymal Stem Cell-Collagen Microspheres During Chondrogenic Differentiation
In this study, a novel human Mesenchymal stem cell-collagen microsphere system was used to study the compositional mechanical relationship during in vitro chondrogenic differentiation using histological and biochemical methods and a microplate compression assay. [Tissue Eng Part A]

A Microfabricated Scaffold Induces the Spheroid Formation of Human Bone Marrow-Derived Mesenchymal Progenitor Cells and Promotes Efficient Adipogenic Differentiation
Here, researchers report the highly efficient in vitro differentiation of human bone marrow-derived mesenchymal stem/progenitor cells using a novel nanotechnology-based culture plate, nanoculture plate (R). [Tissue Eng Part A]

Synergistic Angiogenesis Promoting Effects of Extracellular Matrix Scaffolds and Adipose-Derived Stem Cells During Wound Repair
The aim of this study was to promote the vascularization capacities of scaffolds by seeding adipose-derived stem cells (ADSCs) on them and to compare the vascularization capacities of different scaffolds seeded with ADSCs. [Tissue Eng Part A]


INDUSTRY NEWS

UC Davis Physicians Awarded State Stem Cell Grants
California’s stem cell agency voted to fund two new grants to UC Davis School of Medicine physicians for their work in regenerative medicine research. [UC Davis School of Medicine Press Release]

State Awards UCLA Stem Cell Researchers $10.4 Million to Develop New Therapies for Disease
California’s state stem cell agency has awarded grants totaling $10.4 million to four researchers to translate basic science into new and more effective therapies to regenerate bone, target deadly brain cancers and treat corneal disorders that result in blindness. [University of California Press Release]

Vitro Expands HemoGenix Alliance to Include Cell-based Testing for Liver Toxicity
Vitro Diagnostics, Inc., dba Vitro Biopharma, announced that it signed an amendment to its contract to jointly manufacture and distribute stem cell analysis tools with HemoGenix(R), Inc., a leading firm known for its pioneering HALO(R) analysis platform for stem cells. [The Wall Street Journal]


POLICY NEWS

NIH Recovery Act Awards Enable Crucial Health Research Technologies
Thanks to the Recovery Act, more health scientists now will have access to state-of-the-art devices, the National Institutes of Health announced. Through its National Center for Research Resources, NIH has awarded $300 million in shared instrumentation grants.  [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26362) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26363) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26317) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26497) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26499) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26028) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26702) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-26706) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26390) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]

Export of Human Blood/Tissue and Related Materials [Therapeutic Goods Administration, Australia]


EVENTS (Listed by Date)

Queen Mary University of London: 5th UK Cancer Stem Cell Symposium
November 2, 2010
London, United Kingdom

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010
Singapore

National Cancer Research Institute (NCRI) Conference 2010
November 7-10, 2010
Liverpool, United Kingdom

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

NEW  Third Annual Research Experience of Stem Cells in European (RESCUE) Society Conference
November 8-9, 2010
Oxford, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

NEW Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

NEW  1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

NEW United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011
Singapore

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.

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