Volume 2.44 | Nov 9

Mesenchymal Cell News 2.44, November 9, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-Alpha 
Researchers created a transgenic mouse in which fibroblast activation protein-alpha (FAP)-expressing cells can be ablated. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-gamma and tumor necrosis factor-alpha. [Science]

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SPECIAL FEATURE

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud
Researchers show that the mesenchymal cells of the early limb bud are not disorganized within the ectoderm as previously thought but are instead highly organized and polarized. [Curr Biol]

Chemotherapy Resistance in Acute Lymphoblastic Leukemia Requires hERG1 Channels and is Overcome by hERG1 Blockers
The findings provide a rationale for clinical testing of hERG1 blockers in the context of antileukemic therapy for patients with acute lymphoblastic leukemia. [Blood]

The Effects of Culture on Genomic Imprinting Profiles in Human Embryonic and Fetal Mesenchymal Stem Cells
The results suggest that regardless of stem cell origin, in vitro culture affects the integrity of imprinted gene expression in human cells. [Epigenetics]

Low Doses of Bone Morphogenetic Protein 4 Increase the Survival of Human Adipose-Derived Stem Cells Maintaining Their Stemness and Multipotency
In this study, researchers demonstrate that human adipose-derived stem cells (ASCs) express all components of the bone morphogenetic protein (BMP)/BMP receptor signaling pathway and respond to BMP4 inducing upregulated expression of its specific target genes Id1-Id4. [Stem Cells Dev]

Mesenchymal Stem Cell Stimulation of Tissue Growth Depends on Differentiation State
This study investigated the stimulatory capacity of mesenchymal stem cells (MSCs) during osteogenesis and the impact of MSC phenotype on cartilage stimulation. [Stem Cells Dev]

Human Term Placenta-Derived Mesenchymal Stromal Cells are Less Prone to Osteogenic Differentiation than Bone Marrow-Derived Mesenchymal Stromal Cells
Researchers conclude that mesenchymal stem cells from different sources differ in their expression of distinct markers, and that this may correlate in part with their lineage determination. [Stem Cells Dev]

Mesenchymal Stem Cells Contribute to the Abnormal Bone Marrow Microenvironment in Patients with Chronic Idiopathic Neutropenia by Overproduction of Transforming Growth Factor-Beta1
In this study, researchers investigated the possible involvement of bone marrow (BM) mesenchymal stem cells (MSCs) in the pathophysiology of chronic idiopathic neutropenia by assessing the frequency and function of BM MSCs in terms of the proliferative/clonogenic characteristics, the differentiation capacity, the potential to produce pro-inflammatory cytokines and the ability to suppress T cell proliferation. [Stem Cells Dev]

Kidney-Derived Mesenchymal Stromal Cells Modulate Dendritic Cell Function to Suppress Alloimmune Responses and Delay Allograft Rejection
The results highlight an important mechanism of mesenchymal stromal cell-based immunotherapy and its potential for use in clinical transplantation as prevention of rejection and possibly sensitization. [Transplantation]

Mechanical Integrin Stress and Magnetic Forces Induce Biological Responses in Mesenchymal Stem Cells Which Depend on Environmental Factors
Together, the results implicate that biological functions of mesenchymal stem cells can be stimulated by integrin-mediated mechanical forces and a magnetic field. However, the responses of cells depend strongly on the substrate to which they adhere and on the cross talk between integrin mediated signals and soluble factors. [J Cell Biochem]

Consistent Osteoblastic Differentiation of Human Mesenchymal Stem Cells With Bone Morphogenetic Protein 4 and Low Serum
In this study, researchers compared the osteogenic differentiation of bone marrow mesenchymal stem cells induced by dexamethasone (Dex) or bone morphogenetic proteins by assessing phenotypes in vitro and functional osteoblasts in vivo. [Tissue Eng Part C Methods]


INDUSTRY NEWS

UCB and Plasticell Partner to Identify Compounds for SC Research and Cell Therapeutics
U.K. stem cell technologies firm Plasticell is to provide UCB with services based on its CombiCult™ screening technology to help identify new indications for compounds in stem cell biology, differentiation, and, potentially, tissue regeneration. [Genetic Engineering & Biotechnology News Press Release]


POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011
Singapore

NEW Adult MSC2011 Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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