Volume 2.45 | Nov 16

Mesenchymal Cell News 2.45, November 16, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Mesenchymal-Lineage Stem Cells Have Pronounced Anti-Inflammatory Effects in the Twitcher Mouse Model of Krabbe’s Disease 
This study evaluates the effect of intracerebroventricular administration of mesenchymal stem cells derived from adipose tissue and bone marrow on the pathology of Krabbe’s disease. [Stem Cells]



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Stem Cell Transplants in Mice Produce Lifelong Enhancement of Muscle Mass
The study shows that specific types of stem cells transplanted into the leg muscles of mice prevented the loss of muscle function and mass that normally occurs with aging, a finding with potential uses in treating humans with chronic, degenerative muscle diseases. [Press release from the University of Colorado at Boulder discussing online prepublication in Science Translational Medicine]

Umbilical Cord Cells May Treat Arthritis
Umbilical cord stem cells may be useful in the treatment of rheumatoid arthritis. Animal and in vitro experiments have shown that mesenchymal stem cells taken from umbilical cord blood can suppress inflammation and attenuate collagen-induced arthritis. [Press release from EurekAlert! discussing online prepublication in Arthritis Research and Therapy]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Mesenchymal Stem Cells Express Serine Protease Inhibitor to Evade Host Immune Response
Researchers conclude that serpin protease inhibitor 6 (SPI6) protects mesenchymal stem cells from granzyme B-mediated killing and plays a pivotal role in their survival in vivo. [Blood]

Continual Expression Throughout the Cell Cycle and Downregulation upon Adipogenic Differentiation Makes Nucleostemin a Vital Human MSC Proliferation Marker
Nucleostemin (NS) is a nucleolar protein expressed in stem and cancer cells. This study analyzes the spatio-temporal (nucleolar/nuclear localization during interphase and M-phase) NS remodeling in two distinct human mesenchymal stem cell (MSC) populations to discriminate the NS differences, if any, throughout their stem cell and differentiation states. [Stem Cell Rev]

Wnt5b Regulates Mesenchymal Cell Aggregation and Chondrocyte Differentiation Through the Planar Cell Polarity Pathway
Although genetic evidence has demonstrated a role for Wnt5b during cartilage and limb development, little is known about the mechanisms underlying Wnt5b-regulated chondrocyte differentiation. Researchers observed that Wnt5b inhibited chondrocyte hypertrophy and expression of type X collagen. [J Cell Physiol]

NOS Inhibition Synchronizes Calcium Oscillations in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Increasing Gap Junctional Coupling
The data demonstrate that intracellular nitric oxide levels regulate synchronization of intracellular calcium oscillations in undifferentiated adipose tissue-derived mesenchymal stem cells by controlling gap junctional coupling. [J Cell Physiol]

Therapeutic Potential of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis
Bone marrow mesenchymal stem cells (MSCs) could be effective in the treatment of several autoimmune diseases. However, there has been thus far no report on umbilical cord (UC)-MSCs in the treatment of rheumatoid arthritis (RA). Here, potential immunosuppressive effects of human UC-MSCs in RA were evaluated. [Arthritis Res Ther]

Prevention of Muscle Aging by Myofiber-Associated Satellite Cell Transplantation
Researchers demonstrate that engraftment of myofiber-associated satellite cells, coupled with an induced muscle injury, markedly alters the environment of young adult host muscle, eliciting a near-lifelong enhancement in muscle mass, stem cell number, and force generation. [Sci Transl Med]



The Maryland Stem Cell Research Commission Announces Opportunity for Collaborative Research Grants with State of California Researchers
The Maryland Technology Development Corporation, which administers the Maryland Stem Cell Research Fund (MSCRF), announced a pilot program with the California Institute for Regenerative Medicine (CIRM), the State’s stem cell research funding agency. [Maryland Stem Cell Research Commission Press Release]

Boost for Regenerative Medicine Research in Ireland
In a major boost for Regenerative Medicine research in Ireland, the Minister for Enterprise, Trade and Innovation announced funding of almost 10 million Euros for the Regenerative Medicine Institute (REMEDI) at NUI Galway. [Science Foundation Ireland Press Release]


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS (Listed by Date)

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium: Stem Cells – Hopes, Fears and Realities
December 1-3, 2010
Berlin, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

NEW  The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

NEW Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

NEW  15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011

Adult MSC2011 Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

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Business Manager – Centre for Blood Cell Therapies (Cell Therapies)

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