Volume 2.46 | Nov 23

Mesenchymal Cell News 2.46, November 23, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Rare Disease Reveals New Path for Creating Stem Cells 
Researchers have found that by mimicking a rare genetic disorder in a dish, they can rewind the internal clock of a mature cell and drive it back into an adult stem-cell stage. [Press release from the Harvard Medical School discussing online prepublication in Nature Medicine]



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Bioengineers Provide Adult Stem Cells with Friendly Environment: Simultaneous Chemical, Electrical and Mechanical Cues
Bioengineers have achieved the “Triple Crown” of stem cell culture — they created an artificial environment for stem cells that simultaneously provides the chemical, mechanical and electrical cues necessary for stem cell growth and differentiation. [Press release from the University of California, San Diego discussing online prepublication in Advanced Functional Materials]

New Study into Bladder Regeneration Heralds Organ Replacement Treatment
Researchers have developed a medical model for regenerating bladders using stem cells harvested from a patient’s own bone marrow. [Press release from PhysOrg discussing online prepublication in Stem Cells]

Treating Heart Attack with Fat-Derived Stem Cells May be Safe in Humans
Fat cells – liposuctioned from a patient’s belly – can safely boost heart function after a heart attack, according to a first-of-its-kind study. [Press release from the American Heart Association discussing data presented at the American Heart Association’s Scientific Sessions 2010]

Regenerative Stem Cell Therapy Offers New Hope for Treating Cardiovascular Disease
Northwestern Medicine physician researchers are revolutionizing treatment of cardiovascular disease by utilizing patients’ own stem cells to regenerate heart and vascular tissue. [Northwestern Memorial Hospital Press Release]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Conversion of Vascular Endothelial Cells into Multipotent Stem-Like Cells
Here, researchers show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2 receptor-dependent mechanism. [Nat Med]

Fus-Chop Fusion Protein Expression Coupled to P53 Deficiency Induces Liposarcoma in Mouse but not Human Adipose-Derived Mesenchymal Stem/Stromal Cells
Human sarcomas have been modeled in mice by expression of specific fusion genes in mesenchymal stem cells (MSCs). However, sarcoma models based on human MSCs are still missing. Researchers attempted to develop a model of liposarcoma by expressing FUS-CHOP, a hallmark mixoid liposarcoma-associated fusion oncogene, in wild-type and p53-deficient mouse and human adipose-derived mesenchymal stem/stromal cells. [Stem Cells]

Enrichment of Human ESC-Derived Multipotent Mesenchymal Stem Cells with Immunosuppressive and Anti-Inflammatory Properties Capable to Protect Against Experimental Inflammatory Bowel Disease
Researchers report an efficient enrichment of mesenchymal stem cells from human embryonic stem cells (ESCs) through specific inhibition of SMAD-2/3 signaling. [Stem Cells]

A Non-Human Primate Model for Urinary Bladder Regeneration Utilizing Autologous Sources of Bone Marrow Derived Mesenchymal Stem Cells
Researchers postulated that mesenchymal stem cells could provide a cell source for partial bladder regeneration in a newly described non-human primate bladder (baboon) augmentation model. [Stem Cells]

Dynamic Electromechanical Hydrogel Matrices for Stem Cell Culture
Researchers report the development of hydrogel based multifunctional matrices that not only provide three-dimensional structural support to the embedded cells but also can simultaneously provide potentially beneficial dynamic mechanical and electrical cues to the cells. [Adv Funct Mater]

Urokinase Receptor Mediates Mobilization, Migration and Differentiation of Mesenchymal Stem Cells
Multipotent mesenchymal stem cells (MSCs) have regenerative properties and are recognized as putative players in the pathogenesis of cardiovascular diseases. The study was designed to elucidate a probable role for the multifunctional urokinase/urokinase receptor system in MSC regulation. [Cardiovasc Res]

Effects of Human Mesenchymal Stem Cells on ER-Positive Human Breast Carcinoma Cells Mediated through ER-SDF-1/CXCR4 Crosstalk
Adult human mesenchymal stem cells (hMSCs) have been shown to home to sites of carcinoma and affect biological processes, including tumor growth and metastasis. Previous findings have been conflicting and a clear understanding of the effects of hMSCs on cancer remains to be established. Therefore, researchers set out to investigate the impact of hMSCs on the estrogen receptor positive, hormone-dependent breast carcinoma cell line MCF-7. [Mol Cancer]

Dormant Phase and Multinuclear Cells: Two Key Phenomena in Early Culture of Murine Bone Marrow Mesenchymal Stem Cells
Here, researchers followed mouse bone marrow mesenchymal stem cells for more than 1 year after isolation and examined the effect of expansion on changes in morphology, growth kinetics, plasticity and chromosomal structure during in vitro culture. [Stem Cells Dev]


CaridianBCT Collaborates with CASCADE Consortium
CaridianBCT announced its collaboration agreement with the Cultivated Adult Stem Cell Alternative for Damaged tissuE (CASCADE) consortium, a European Union project consisting of 16 organizations, to continue the development of culturing adult stem cells for clinical applications. [CaridianBCT Press Release]

Stratophase Collaborates with LGC on Real-Time Monitoring of 3D Cell Culture Growth
By using Stratophase’s innovative SpectroSens insertion probe, LGC has demonstrated its potential to improve the monitoring of cell growth in a 3D culture by enabling real-time measurement of nutrient metabolism and the build-up of waste products. [Stratophase Limited Press Release]


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS (Listed by Date)

Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium: Stem Cells – Hopes, Fears and Realities
December 1-3, 2010
Berlin, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

NEW SMi Stem Cells 2011 – Innovation & Commercialisation
February 23-24, 2011
London, United Kingdom

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

StemCONN 11
March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011

Adult MSC2011 Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Product Manager – Pluripotent Stem Cells (STEMCELL Technologies)

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