Volume 2.48 | Dec 7

Mesenchymal Cell News 2.48, December 7, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

CDK1-Dependent Phosphorylation of EZH2 Suppresses Methylation of H3K27 and Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells  ShareThis
Here, researchers demonstrate that enhancer of zeste homologue 2 (EZH2) can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1). The findings define a signalling link between CDK1 and EZH2 that may have an important role in diverse biological processes, including cancer-cell invasion and osteogenic differentiation of mesenchymal stem cells. [ Nat Cell Biol]

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SPECIAL FEATURE

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SCIENCE NEWS

Tuberculosis May Use Bone Stem Cells to Evade Immune System, Study Finds
Tuberculosis bacteria recruits mesenchymal stem cells to the lungs, where they help suppress the immune system that fights disease, scientists said. [Press release from Bloomberg discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Human Bone Marrow-Derived Clonal Mesenchymal Stem Cells Inhibit Inflammation and Reduce Acute Pancreatitis in Rats
Researchers developed a protocol to isolate human bone marrow-derived clonal mesenchymal stem cells from bone marrow aspirate and investigated the effects of these cells in rat models of mild and severe acute pancreatitis. [Gastroenterology]

TNF-Alpha Respecifies Human Mesenchymal Stem Cells to a Neural Fate and Promotes Migration Toward Experimental Glioma
Taken together, the results provide evidence that culture-expansion of human mesenchymal stem cells (hMSCs) in the presence of TNF-alpha triggers neural gene expression and functional capacities, which could improve the use of hMSCs in the treatment of neurological disorders including malignant gliomas. [Cell Death Differ]

Zinc Finger Protein 467 is a Novel Regulator of Osteoblast and Adipocyte Commitment
The bone loss of osteoporosis is associated with altered progenitor differentiation from an osteoblastic to an adipocytic lineage. cDNA microarrays and quantitative real-time PCR were carried out in a differentiating mouse stromal osteoblastic cell line, Kusa 4b10, to identify gene targets of factors that stimulate osteoblast differentiation including parathyroid hormone and gp130-binding cytokines, oncostatin M and cardiotrophin-1. [J Biol Chem]

Ultrastructural and Immunocytochemical Analysis of Multilineage Differentiated Human Dental Pulp- and Umbilical Cord-Derived Mesenchymal Stem Cells
In order to assess the potential of dental pulp-derived mesenchymal stem cells (DPSC) and umbilical cord-derived mesenchymal stem cells (UCSC) in future clinical applications, it is essential to gain more insight into their differentiation capacity and to evaluate the tissues formed by these cells. In the present study, the morphological and ultrastructural characteristics of DPSC and UCSC induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated. [Cells Tissues Organs]

Pegylated TRAIL Retains Anti-Leukemic Cytotoxicity and Exhibits Improved Signal Transduction Activity with Respect to TRAIL
To improve the pharmacokinetic profile of tumor necrosis factor-related apoptosis inducing ligand (TRAIL), an N-terminal specific pegylation was performed to generate pegylated TRAIL (PEG-TRAIL). In in vitro experiments, researchers found that although PEG-TRAIL was slightly less efficient than recombinant TRAIL in promoting leukemic cell apoptosis, it showed an improved ability to promote migration of bone-marrow mesenchymal stem cells and to elicit the ERK1/2 intracellular signal transduction pathway. [Invest New Drugs]

INDUSTRY NEWS

UVA Researchers Developing Innovative Ways to Heal Severe Bone Fractures Through Combined Adult Stem Cell and Genetic Therapy
Millions of Americans each year suffer broken bones, and a majority recover without complications. But as many as one in five bone fracture patients face prolonged and complicated treatments such as bone grafts, synthetic bone replacement and multiple surgeries – all resulting in risk of infection. With the help of a $100,000 grant from the Orthopaedic Research and Education Foundation, researchers are developing innovative ways to overcome these problems by harnessing the body’s own regenerative powers to restore lost bone by combining gene therapy and adult stem cell therapy. [University of Virginia Health System Press Release]


POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

The 3rd Young Investigator Stem Cell Meeting
December 14, 2010
Tel Aviv, Israel

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

SMi Stem Cells 2011 – Innovation and Commercialisation
February 23-24, 2011
London, United Kingdom

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

StemCONN 11
March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011
Singapore

Adult MSC2011 Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Cell Therapy Manufacturing – Stem Cells and Immunotherapeutics
December 1-2, 2011
London, United Kingdom

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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