Volume 2.49 | Dec 14

Mesenchymal Cell News 2.49, December 14, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Cells ‘Feel’ the Difference Between Stiff or Soft and Thick or Thin Matrix 
Cultured mesenchymal stem cells can “feel” at least several microns below the surface of an artificial microfilm matrix, gauging the elasticity of the extracellular bedding that is a crucial variable in determining their fate, researchers reported. [Press release from ScienceDaily discussing data presented at the American Society for Cell Biology’s 50th Annual Meeting]

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SCIENCE NEWS

A ‘Stitch in Time’ Could Help Damaged Hearts
A research team shows that stem cells thrive on microthread sutures, creating a novel platform for cellular therapies that may regenerate cardiac tissue. [Press release from the Worcester Polytechnic Institute discussing online prepublication in the Journal of Biomedical Materials Research Part A]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells
Using human embryonic stem cells directed toward mesendodermal differentiation, researchers show that mesenchymal stem/stromal cells originate from a population of mesodermal cells identified by expression of apelin receptor. [Cell Stem Cell]

The Effects of Culture on Genomic Imprinting Profiles in Human Embryonic and Fetal Mesenchymal Stem Cells
Genes subject to epigenetic regulation via genomic imprinting have been characterized extensively. The integrity of imprinted gene expression therefore provides a measurable index for epigenetic stability. Allelic expression of 26 imprinted genes and DNA methylation at associated differentially methylated regions (DMRs) was measured in fetal mesenchymal stem cells and human embryonic stem cell lines. [Epigenetics]

Phenotypic Differences During the Osteogenic Differentiation of Single Cell-Derived Clones Isolated from Human Lipoaspirates
Single-cell clones were isolated and expanded from human lipoaspirate cells. Osteogenic differentiation was induced and studied in defined media, using four representative isolated cell clones showing differences in the basal expression of a set of characteristic osteogenic genes. [J Tissue Eng Regen Med]

Fibrin Microthreads Support Mesenchymal Stem Cell Growth While Maintaining Differentiation Potential
To assess the efficacy of fibrin microthreads to support human mesenchymal stem cell (hMSC) attachment, proliferation, and survival, microthreads (100 micrometer diameter per microthread) were bundled together, seeded with 50,000 hMSCs for 2 hours, and cultured for 5 days. [J Biomed Mater Res A]

Correlation Between Compositional and Mechanical Properties of Human Mesenchymal Stem Cell-Collagen Microspheres During Chondrogenic Differentiation
In this study, a novel human mesenchymal stem cell-collagen microsphere system was used to study the compositional mechanical relationship during in vitro chondrogenic differentiation using histological and biochemical methods and a microplate compression assay. [Tissue Eng Part A]


INDUSTRY NEWS

Mesoblast and Cephalon Enter into Strategic Alliance to Commercialize Novel Therapeutic Products for Regenerative Medicine
Regenerative medicine company, Mesoblast Limited and global biopharmaceutical company, Cephalon, Inc., announced they have entered into a strategic alliance to develop and commercialize novel adult stem cell therapeutics for degenerative conditions of the central nervous and cardiovascular systems. [Mesoblast Limited Press Release]

Cytori Enters Strategic Equity Deal with Astellas Pharma; To Sell $10 Million in Equity at $7.00 Per Share
Cytori Therapeutics and Astellas Pharma Inc. have entered into a strategic equity agreement to evaluate the potential of adipose derived stem and regenerative cells for the treatment of serious illnesses for which there is no fundamental treatment. [Cytori Therapeutics Press Release]


POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS (Listed by Date)

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

SMi Stem Cells 2011 – Innovation and Commercialisation
February 23-24, 2011
London, United Kingdom

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

StemCONN 11
March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011
Singapore

Adult MSC2011 Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Cell Therapy Manufacturing – Stem Cells and Immunotherapeutics
December 1-2, 2011
London, United Kingdom

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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