Volume 2.50 | Dec 21

Mesenchymal Cell News 2.50, December 21, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

miR-335 Orchestrates Cell Proliferation, Migration and Differentiation in Human Mesenchymal Stem Cells
Researchers aimed to identify microRNAs (miRNAs) involved in controlling the transition between the resting and reparative phenotypes of human mesenchymal stem cells, hypothesizing that these miRNAs must be present in the undifferentiated cells and downregulated to allow initiation of distinct activation/differentiation programs. [Cell Death Differ]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Linking Transgene Expression of Engineered Mesenchymal Stem Cells and Angiopoietin-1-induced Differentiation to Target Cancer Angiogenesis
The purpose of this study was to specifically target tumor angiogenesis by linking transgene expression of engineered mesenchymal stem cells to angiopoietin-1-induced differentiation. [Ann Surg]

Selective Venous Catheterization for the Localization of Phosphaturic Mesenchymal Tumors
Tumor-induced osteomalacia is characterized by renal phosphate wasting, hypophosphatemia, aberrant Vitamin D3 metabolism, and is caused by FGF23-producing mesenchymal tumors, which are often difficult to locate. Researchers investigated the utility of selective venous sampling in tumor localization. [J Bone Miner Res]

Biphasic Effects of Transforming Growth Factor-Beta on Bone Morphogenetic Protein-Induced Osteoblast Differentiation
In order to identify kinases mediating bone morphogenetic protein (BMP)-induced osteoblast differentiation, researchers performed a siRNA screen to find kinases modulating BMP6-induced alkaline phosphatase (ALP) activity. [J Bone Miner Res]

Urokinase Receptor Mediates Mobilization, Migration, and Differentiation of Mesenchymal Stem Cells
Multipotent mesenchymal stem cells (MSCs) have regenerative properties and are recognized as putative players in the pathogenesis of cardiovascular diseases. The underlying molecular mechanisms remain, however, sparsely explored. This study was designed to elucidate a probable role for the multifunctional urokinase (uPA)/urokinase receptor (uPAR) system in MSC regulation. [ Cardiovasc Res]

Mesenchymal Stem Cell Transplantation Modulates Neuroinflammation in Focal Cerebral Ischemia: Contribution of Fractalkine and IL-5
In this study, researchers have investigated the neuroimmunomodulatory functions of human mesenchymal stem cells, transplanted in rat focal ischemia model of transient middle cerebral artery occlusion. [Neurobiol Dis]

Role of TRX 1 and TRX2 on Proliferation of Human Adipose Tissue-Derived Mesenchymal Stem Cells
To investigate the role of thioredoxin (TRX)1 and TRX2 in human adipose tissue-derived mesenchymal stem cells (hADSC), researchers modulated TRX1 and TRX2 expressions in hADSC using a lentiviral gene transfer system and siRNA technique. [Stem Cells Dev]

Tubular Perfusion System for the Long-Term Dynamic Culture of Human Mesenchymal Stem Cells
To enhance nutrient transport researchers have developed a novel bioreactor, the tubular perfusion system, to culture human mesenchymal stem cells in three-dimensional scaffolds. [Tissue Eng Part C Methods]

Optimization of Culture Conditions for the Expansion of Umbilical Cord Derived MSC Like Cells Using Xeno-Free Culture Conditions
First isolated from bone marrow, mesenchymal stem or stromal cells (MSC) were shown to be present in several post-natal and extraembryonic tissues as well as in a large variety of fetal tissues (e.g. fatty tissue, dental pulp, placenta, umbilical cord blood and tissue). In this study, an optimized protocol for the expansion of MSC-like cells from whole umbilical cord tissue under xeno-free culture conditions is proposed. [Tissue Eng Part C Methods]

Defining Characteristics of Bona Fide Human iPS Cells
Speaker: Sutheera Ratanasirintrawoot, PhD Candidate
G. Daley & T. Schlaeger Labs, Harvard Medical School
WEBINAR: VIEW HERE STEMCELL Technologies Inc


INDUSTRY NEWS

CIRM Governing Board Re-Elects Robert Klein as Chair, Senator Art Torres and Duane Roth as Co-Vice Chairs
The Governing Board of the California Institute for Regenerative Medicine (CIRM), the state stem cell agency created by proposition 71, voted to re-elect current chair Robert Klein. [California Institute for Regenerative Medicine Press Release]

Cryo-Save to Launch Cryo-Lip in the U.S.
Cryo-Save Group N.V., Europe’s leading stem cell bank, announced that it intends to launch Cryo-Lip in the United States in 2011, after the successful introduction of the service in Europe during 2010. Cryo-Save is one of the first in the world that offers cryostorage of adult mesenchymal stem cells from fatty tissue for use by patients undergoing a surgical procedure. [Cryo-Save Group N.V. Press Release]

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)



EVENTS (Listed by Date)

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, D.C., United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

1st Annual Clinical Meeting of the Cell Society
February 18-19, 2011
La Jolla, United States

SMi Stem Cells 2011 – Innovation and Commercialisation
February 23-24, 2011
London, United Kingdom

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

StemCONN 11
March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011
Singapore

Adult MSC2011 Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Cell Therapy Manufacturing – Stem Cells and Immunotherapeutics
December 1-2, 2011
London, United Kingdom

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

JOB OPPORTUNITIES


Lab Technologist – Cell Separation (STEMCELL Technologies)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)


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