Volume 3.03 | Jan 25

Mesenchymal Cell News 3.03, January 25, 2011.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Rescuing Replication and Osteogenesis of Aged Mesenchymal Stem Cells by Exposure to a Young Extracellular Matrix 
This study aimed to determine whether aging negatively affects mesenchymal stem cell replication and osteogenesis and whether these features could be altered by exposure to an extracellular matrix generated by marrow cells from young or old mice. [FASEB J]

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SCIENCE NEWS

Uncovering the Trail Behind Growing Too Old, Too Soon
Scientists from A*STAR’s Institute of Medical Biology (IMB) in Singapore and the University of Hong Kong’s Department of Medicine have produced the world’s first human cell model of progeria. The team used a novel technique of deriving induced pluripotent stem cells from cells of human progeria patients.  The researchers used their iPS cells to identify two types of cells — mesenchymal stem cells and vascular smooth muscle cells — that were particularly adversely affected by progeria. [Press release from ScienceDaily discussing online prepublication in Cell Stem Cell]


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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects
Because mesenchymal stem cells (MSCs) reside in low oxygen niches in vivo, researchers propose that, in Hutchinson-Gilford Progeria syndrome, this causes additional depletion of the MSC pool responsible for replacing differentiated cells lost to progerin toxicity. [Cell Stem Cell]

Hypoxia-Inducible Vascular Endothelial Growth Factor-Engineered Mesenchymal Stem Cells Prevent Myocardial Ischemic Injury
In an effort to reduce ischemic myocardial damage, researchers investigated the effects on infarcted myocardium of transplantation of genetically modified mesenchymal stem cells (MSCs) that specifically expressed vascular endothelial growth factor (VEGF) under hypoxic conditions. [Mol Ther]

MITR is a Switch that Promotes Osteogenesis and Inhibits Adipogenesis of Mesenchymal Stem Cells by Inactivating PPAR(gamma)-2
Results demonstrated that MITR plays a master switch role to balance osteogenic and adipogenic differentiation of mesenchymal stem cells through regulation of PPAR(gamma)-2 transcriptional activity. [J Biol Chem]

Dynamic Tensile Loading Improves the Functional Properties of MSC-Laden Nanofiber-Based Fibrocartilage
The results show that dynamic tensile loading enhances the maturation of mesenchymal stem cell (MSC)-laden aligned nanofibrous constructs, suggesting that recapitulation of the structural and mechanical environment of load-bearing tissues results in increases in functional properties which can be exploited for tissue engineering applications. [Tissue Eng Part A]

Trophic Effects of Mesenchymal Stem Cells Increase Chondrocyte Proliferation and Matrix Formation
Previous studies showed that co-culture of primary chondrocytes with various sources of multipotent cells results in a higher relative amount of cartilage matrix formation than cultures containing only chondrocytes. The aim of this study is to investigate the mechanism underlying this observation. [Tissue Eng Part A]

Mesenchymal Stem Cell Characteristics of Human Anterior Cruciate Ligament Outgrowth Cells
When ruptured, the anterior cruciate ligament (ACL) of the human knee has limited regenerative potential. However, the goal of this report was to show, that the cells that migrate out of the human ACL constitute a rich population of progenitor cells and researchers hypothesize that they display mesenchymal stem cell (MSC) characteristics when compared with adherent cells derived from bone marrow or collagenase digests from ACL. [Tissue Eng Part A]

In Vitro Assessment of the Differentiation Potential of BMSCs on Genipin-Chitosan Conjugation Scaffold with Surface Hydroxyapatite Nanostructure for Bone Tissue Engineering
In this study, researchers examined the effect of surface biomimetic apatite nanostructure of a new hydroxyapatite coated genipin-chitosan conjugation scaffold on cell shape, cytoskeleton organization and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) in vitro. [Tissue Eng Part A]

Effects of Nanofiber/Stem Cell Composite on Wound Healing in Acute Full-Thickness Skin Wounds
Acute full-thickness skin wounds (FTSW) caused by extensive burns or high energy trauma are not adequately addressed by current clinical treatments. This study hypothesized that biomimetic nanofiber scaffolds (NFS) functionalized with rich attachment of bone marrow-derived mesenchymal stem cells (BM-MSCs) can promote wound healing in acute FTSW. [Tissue Eng Part A]

Exploitation of Herpesvirus Immune Evasion Strategies to Modify the Immunogenicity of Human Mesenchymal Stem Cell Transplants
Researchers aim to overcome mesenchymal stem cell (MSC) immune rejection through permanent down-regulation of major histocompatibility complex (MHC) class I proteins on the surface of these MHC class II-negative cells through the use of viral immune evasion proteins. [PLoS ONE]



INDUSTRY NEWS

NeoStem Acquires Progenitor Cell Therapy
NeoStem, Inc.and Progenitor Cell Therapy LLC announced the closing of their previously announced merger transaction. [NeoStem, Inc. Press Release]

Adipose-Derived Regenerative Cell (ADRC) Therapy Associated With Reduction in Arrhythmia in Acute Heart Attack Patients; Post-Hoc Data From Cytori’s APOLLO Study Reported at the 6th International Conference on Cell Therapy for Cardiovascular Disease
Cytori Therapeutics announced the presentation of data demonstrating a statistically significant reduction in ventricular tachyarrhythmias following adipose-derived regenerative cell (ADRC) therapy in patients with acute heart attack. [Cytori Therapeutics Press Release]

Wisconsin Stem Cell Pioneer Wins Faisal International Prize
James Thomson, director of regenerative biology at the Morgridge Institute for Research and a University of Wisconsin-Madison researcher since 1994, learned this week that he is this year’s co-winner of the prestigious King Faisal International Prize in Medicine. [Morgridge Institute for Research Press Release]



POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


EVENTS

NEW Annual International Conference on Stem Cell Research (SCR 2011)
April 25-26, 2011
Penang, Malaysia


Visit our events page to see a complete list of events in the mesenchymal cell community.



JOB OPPORTUNITIES



Lab Technologist – Cell Separation (STEMCELL Technologies)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

Scientist – Postdoc “Mesenchymal Stem Cells” (German Research Center for Environmental Health)


PhD Fellowship: Transcriptional Networks Regulating Mesenchymal Stem Cell Differentiation (University of Southern Denmark, Odense)

Tissue Engineer/Assistant Professor (The University of Texas Health Science Center at Houston)

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