Volume 3.07 | Feb 22

Mesenchymal Cell News 3.07, February 22, 2011.
     In this issue: Science News | Current Publications | Industry News | Policy News | Events

The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche
The hair follicle bulge in the epidermis associates with the arrector pili muscle that is responsible for piloerection (“goosebumps”). Researchers show that stem cells in the bulge deposit nephronectin into the underlying basement membrane, thus regulating the adhesion of mesenchymal cells expressing the nephronectin receptor, (alpha)8(beta)1 integrin, to the bulge. [Cell]



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Study Confirms Third Trimester Amniotic Fluid a Reliable Source of Stem Cells for Regenerative Medicine and Stem Cell Banking
Scientists confirmed that amniotic fluid collected during the third trimester of pregnancy is a reliable source of stem cells for 
regenerative medicine and stem cell banking. Amniotic fluid has emerged as one of the most attractive sources of mesenchymal stem cells with broad utility for stem cell therapy development. [Press release from PR Newswire discussing research presented at the Society for Maternal-Fetal Medicine’s annual meeting in San Francisco]

AAOS: Stem Cell Therapy Speeds Fracture Union
Patients with slow-healing distal tibial fractures showed faster bone union when they were injected with concentrated, autologous mesenchymal 
stem cells along with platelet-rich plasma, a researcher reported. [Press release from Medpage Today discussing research presented at the American Academy of Orthopaedic Surgeons’ meeting]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
Using mouse models of inflammation-induced gastric cancer, researchers show that at least 20% of carcinoma-associated fibroblasts originate from bone marrow and derive from mesenchymal stem cells. [Cancer Cell]

Notch1 in Bone Marrow–Derived Cells Mediates Cardiac Repair After Myocardial Infarction
The findings indicate that Notch1 signaling in bone marrow (BM)-derived cells is critical for cardiac repair and suggest that strategies that increase Notch1 signaling in BM-derived mesenchymal stem cells could have therapeutic benefits in patients with ischemic heart disease. [Circulation]

The Performance of Human Mesenchymal Stem Cells Encapsulated in Cell-Degradable Polymer-Peptide Hydrogels

Here, researchers have encapsulated human mesenchymal stem cells (hMSCs) in matrix metalloproteinase (MMP) degradable and cell-adhesive
hydrogels using thiol-ene photopolymerization. Researchers find that hMSCs survive equally well in this system, regardless of
MMP-degradability. [Biomaterials]

Chondrogenesis of Human Mesenchymal Stem Cells Mediated by the Combination of SOX Trio SOX5, 6, and 9 Genes Complexed with PEI-Modified PLGA Nanoparticles
Target gene transfection for desired cell differentiation has recently become a major issue in stem cell therapy. For the safe and stable delivery of genes into human mesenchymal stem cells (hMSCs), researchers employed a non-viral gene carrier system such as polycataionic polymer, poly(ethyleneimine), polyplexed with a combination of SOX5, 6, and 9 fused to green fluorescence protein, yellow fluorescence
protein, or red fluorescence protein coated onto PLGA nanoparticles. [Biomaterials]

High-Throughput Cell Cycle Synchronization Using Inertial Forces in Spiral Microchannels
Here researchers introduce a spiral microfluidic device for cell cycle synchronization, using the combined effects of inertial forces and Dean drag force. By exploiting the relationship between cell diameter and cell cycle (DNA content/ploidy), researchers have successfully fractionated several asynchronous mammalian cell lines, as well as primary cells comprising bone marrow-derived human mesenchymal stem cells, into enriched subpopulations of G0/G1 (>85%), S, and G2/M phases. [Lab Chip]

p85(alpha) Regulates Osteoblast Differentiation by Cross-Talking with MAPK Pathway
To determine whether p85(alpha) subunit of PI3K affects biological functions of mesenchymal stem cells (MSCs), bone marrow derived wild type and p85(alpha) deficient [p85(alpha)-/-] cells were employed in this study. [J Biol Chem]

Activation of Autophagy in Mesenchymal Stem Cells Provides Tumor Stromal Support
In this study, researchers investigated the survival mechanisms used by stressed stromal cells in breast cancers. Researchers used serum-deprived mesenchymal stem cells and MCF-7 breast cancer cells as model system with a hypothesis that stromal cells in the nutrient deprived core utilize survival mechanisms for supporting surrounding cells. [Carcinogenesis]

Differentiated Mesenchymal Stem Cells for Sciatic Nerve Injury
Researchers have been successful in converting bone marrow-derived mesenchymal stem cells into astrocyte-like cells that produce and secrete NTFs (NTF+ cells). In the current study, researchers examined whether NTF+ cells are capable of rescuing motor neurons in a rat sciatic nerve injury model, where the right hind limb sciatic nerve was crushed. [Stem Cells Dev]

Fibroblasts Share Mesenchymal Phenotypes with Stem Cells, but Lack Their Differentiation and Colony Forming Potential
Although mesenchymal stem cells and fibroblasts have been well studied, differences between these two cell types are not fully understood. Researchers therefore comparatively analyzed antigen and gene profiles, colony-forming ability, and differentiation potential of four human cell types in vitro: commercially available skin-derived fibroblasts, adipose tissue-derived stem cells, embryonic lung fibroblasts, and dermal microvascular endothelial cells. [Biol Cell]

Peripheral Nerve Regeneration Using Autologous Porcine Skin-Derived Mesenchymal Stem Cells
To evaluate the in vivo peripheral nerve regeneration potential of porcine skin-derived mesenchymal stem cells (pSMSCs), a total of 5 x 106 autologous pSMSCs labelled with tracking dye, supplemented with fibrin glue scaffold and collagen tubulization, were transplanted into the peripheral nerve defected miniature pigs. [J Tissue Eng Regen Med]


Stemedica Receives Approval From UCSD to Initiate Ischemic Stroke Study with Adult Allogeneic Stem Cells
Stemedica Cell Technologies, Inc., a leader in adult allogeneic stem cell manufacturing, research and development announced that it has
received IRB approval from the University of California, San Diego (UCSD) to initiate a Stemedica clinical study entitled, “A Phase I/II, Multi-Center, Open-Label Study to Assess the Safety, Tolerability and Preliminary Efficacy of a Single Intravenous Dose of Allogeneic Mesenchymal Bone Marrow Cells to Subjects With Ischemic Stroke”. [Stemedica Cell Technologies, Inc. Press Release] 


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW MSC2011: Innovations in Cell-Based Regenerative Therapies
August 22-24, 2011
Cleveland, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

PhD Fellowship: Transcriptional Networks Regulating Mesenchymal Stem Cell Differentiation (University of Southern Denmark, Odense)

Field Applications Specialist – Cell Therapy (Pall Corporation) 

Postdoctoral Position – Scientist (Helmholtz Zentrum München – German Research Center for Environmental Health – Helmholtz Association)

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