Volume 3.08 | Mar 1

Mesenchymal Cell News 3.08, March 1, 2011.
     In this issue: Science News | Current Publications | Industry News | Policy News | Events

Knockdown of p21(Cip1/Waf1) Enhances Proliferation, the Expression of Stemness Markers, and Osteogenic Potential in Human Mesenchymal Stem Cells
These data successfully demonstrate the involvement of senescence gene in the expression of stemness markers and osteogenic potential of human bone marrow-derived multipotent stromal cells. [Aging Cell]


Protein and microRNA Block Cellular Transition Vital to Metastasis
Long known for monitoring DNA damage and forcing defective cells to kill themselves,  p53 also activates bits of RNA that block two proteins, the researchers found. This prevents conversion of epithelial-differentiated cells, which line or cover an organ, into cells that resemble mesenchymal stem cells when stimulated by the TGF-beta growth factor. [Press release from The University of Texas MD Anderson Cancer Center discussing online prepublication in Nature Cell Biology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

p53 Regulates Epithelial–Mesenchymal Transition and Stem Cell Properties through Modulating miRNAs
Here, using genomic approaches, researchers show that tumour suppressor p53 has a role in regulating both epithelial–mesenchymal transition (EMT) and EMT-associated stem cell properties through transcriptional activation of the microRNA miR-200c. [Nat Cell Biol]

Gap Junction–Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells
Here researchers investigated the role of microRNAs (miRNA) transmitted from bone marrow stroma to breast cancer cells via gap junctions and exosomes in tumor cell quiescence. [Cancer Res]

Bone Marrow Stromal Cells Promote Skilled Motor Recovery and Enhance Contralesional Axonal Connections After Ischemic Stroke in Adult Mice
Researchers tested the effect of bone marrow stromal cells on neuronal remodeling of the corticospinal tract originating from the contralesional cortex in mice subjected to unilateral pyramidotomy followed by middle cerebral artery occlusion. [Stroke]

Human Prostate Cancer Harbors the Stem Cell Properties of Bone Marrow Mesenchymal Stem Cells
Researchers examined human prostate cancer cell lines and clinical prostate cancer specimens for additional bone marrow mesenchymal stem cell properties. [Clin Cancer Res]

VEGF/SDF-1 Promotes Cardiac Stem Cell Mobilization and Myocardial Repair in the Infarcted Heart
The objective of this study was to investigate whether vascular endothelial growth factor (VEGF) secreted by mesenchymal stem cells (MSC) improves myocardial survival and the engraftment of implanted MSC in infarcted hearts and promotes recruitment of stem cells through paracrine release of myocardial stromal cell-derived factor-1(alpha) [SDF-1(alpha)]. [Cardiovasc Res]

Anatomical Site Influences the Differentiation of Adipose-Derived Stem Cells for Schwann-Cell Phenotype and Function
Researchers show that adipose-derived stem cell (ASC) source is a major determining factor of immunophenotype, multilineage differentiation, Schwann-cell protein expression, and paracrine ability to stimulate neuronal growth. [Glia]

Cell Origin of Human Mesenchymal Stem Cells Determines a Different Healing Performance in Cardiac Regeneration
This study was to assess the regenerative potential of human mesenchymal stem cells (hMSC) from different origins and to evaluate the role of CD105 in cardiac regeneration. [PLoS ONE]

Dermal Matrix Scaffold Engineered with Adult Mesenchymal Stem Cells and Platelet-Rich Plasma as a Potential Tool for Tissue Repair and Regeneration
The purpose of this study was to investigate the efficacy of Integra(R), an artificial dermal matrix used as a dermal template for skin regeneration, to form a multifunctional scaffold with human bone marrow-derived mesenchymal stem cells and platelet-rich plasma for tissue engineering and regenerative technology. [J Tissue Eng Regen Med]

Overexpression of Cellular Repressor of E1A-Stimulated Genes Inhibits TNF-alpha-induced Apoptosis via NF-(kappa)B in Mesenchymal Stem Cells
This study aimed to determine if rat bone marrow mesenchymal stem cells (MSCs) transfected with cellular repressor of E1A-stimulated genes (CREG)-were able to effectively resist apoptosis induced by inflammatory mediators, and to demonstrate the mechanism of CREG action. [Biochem Biophys Res Commun]

BrainStorm Cell Therapeutics Raises $3.6 Million from Institutional and Private Investors in Equity Financing 
BrainStorm Cell Therapeutics Inc., a leading developer of adult stem cell technologies and therapeutics, announced that it has entered into securities purchase agreements with certain institutional and other investors in connection with a private placement financing in reliance upon Regulation S. [BrainStorm Cell Therapeutics Inc. Press Release]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

17th Annual International Society for Cellular Therapy (ISCT) Meeting
May 18-21, 2011
Rotterdam, The Netherlands

Visit our events page to see a complete list of events in the mesenchymal cell community.

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

Field Applications Specialist – Cell Therapy (Pall Corporation) 

Postdoctoral Position – Scientist (Helmholtz Zentrum München – German Research Center for Environmental Health – Helmholtz Association)

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