Protein and microRNA Block Cellular Transition Vital to Metastasis Long known for monitoring DNA damage and forcing defective cells to kill themselves, p53 also activates bits of RNA that block two proteins, the researchers found. This prevents conversion of epithelial-differentiated cells, which line or cover an organ, into cells that resemble mesenchymal stem cells when stimulated by the TGF-beta growth factor. [Press release from The University of Texas MD Anderson Cancer Center discussing online prepublication in Nature Cell Biology]
VEGF/SDF-1 Promotes Cardiac Stem Cell Mobilization and Myocardial Repair in the Infarcted Heart The objective of this study was to investigate whether vascular endothelial growth factor (VEGF) secreted by mesenchymal stem cells (MSC) improves myocardial survival and the engraftment of implanted MSC in infarcted hearts and promotes recruitment of stem cells through paracrine release of myocardial stromal cell-derived factor-1(alpha) [SDF-1(alpha)]. [Cardiovasc Res]
BrainStorm Cell Therapeutics Raises $3.6 Million from Institutional and Private Investors in Equity Financing BrainStorm Cell Therapeutics Inc., a leading developer of adult stem cell technologies and therapeutics, announced that it has entered into securities purchase agreements with certain institutional and other investors in connection with a private placement financing in reliance upon Regulation S. [BrainStorm Cell Therapeutics Inc. Press Release]
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