Volume 3.14 | Apr 12

Mesenchymal Cell News 3.14, April 12, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events

Dual Origin of Mesenchymal Stem Cells Contributing to Organ Growth and Repair
By using genetic lineage tracing, researchers show that some pericytes differentiate into specialized tooth mesenchyme-derived
cells—odontoblasts—during tooth growth and in response to damage in vivo. [Proc Natl Acad Sci USA]



Helping the Heart Help Itself
Some stem cells in the bone marrow, called c-kit+ cells, appear capable of stimulating adult stem cells already present in the heart to repair the damaged tissue. [Press release from Harvard University discussing online prepublication in Cell Stem Cell]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair
Findings suggest that stimulation of endogenous cardiogenic progenitor activity is a critical mechanism of cardiac cell therapy. [Cell Stem Cell]

Dose-Dependent Effects of R-Sulforaphane Isothiocyanate on the Biology of Human Mesenchymal Stem Cells, at Dietary Amounts, it Promotes Cell Proliferation and Reduces Senescence and Apoptosis, While at Anti-Cancer Drug Doses, it Has a Cytotoxic Effect
Researchers evaluated the effects of sulforaphane [(−)1-isothiocyanato-4R-(methylsulfinyl)-butane] (R-SFN) on the biology of human mesenchymal stem cells. [Age]

A Therapeutic Role for Mesenchymal Stem Cells in Acute Lung Injury Independent of Hypoxia-Induced Mitogenic Factor
In this study, researchers evaluated the therapeutic role of bone marrow mesenchymal stem cell (MSC) transplantation in lipopolysaccaride-induced acute lung injury and assessed the importance of hypoxia-induced mitogenic factor in MSC transplantation. [J Cell Mol Med]

Regeneration of Three Layers Vascular Wall by using BMP2-Treated MSC Involving HIF-1α and Id1 Expressions Through JAK/STAT Pathways
The aim of the present study was to evaluate the collaborative effect of recombinant human—BMP2 and bone marrow—mesenchymal stem cells seeded on a vascular patch to regenerate a vascular arterial wall in a rat model. [Stem Cell Rev]

Mesenchymal Stem Cell Transplantation Changes the Gene Expression Profile of the Neonatal Ischemic Brain
Researchers show for the first time that in the neonatal ischemic brain survival of transplanted mesenchymal stem cells is very limited. [Brain Behav Immun]

5-Azacytidine Induces Cardiac Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells by Activating Extracellular Regulated Kinase (ERK)
Here, researchers demonstrated that 5-Azacytidine induced cardiac differentiation of human umbilical cord-derived mesenchymal stem cells and explored the potential signaling pathway. [Stem Cells Dev]

Paracrine Effect of Wnt11 Overexpressing Mesenchymal Stem Cells on Ischemic Injury
In this study, researchers investigated whether Wnt11 enhances mesenchymal stem cell-mediated cardioprotection via paracrine fashion following acute ischemia. [Stem Cell Dev]

Estrogen Reduces Cellular Aging in Human Mesenchymal Stem Cells and Chondrocytes
Estrogen exerts profound effects on human physiology including articular cartilage and mesenchymal stem cells. The present study should analyze the effects of pre- and postmenopausal estrogen concentrations on chondrogenic cells. [J Orthop Res]


Former Deloitte Executive Joins BrainStorm Cell Therapeutics as Independent Director and Chairman of the Audit Committee
BrainStorm Cell Therapeutics Inc., a leading developer of adult stem cell technologies and therapeutics, announced that Mordechai (Moti) Friedman, CPA, a former Deloitte Brightman Almagor executive and deputy chairman, has been elected as an independent director of the Company. [BrainStorm Cell Therapeutics Inc. Press Release]

MRC-CRM and iCeMS Sign Agreement on Academic Collaboration
The University of Edinburgh’s Medical Research Council Centre for Regenerative Medicine (MRC-CRM) and Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS) signed a memorandum of understanding covering future collaborative research. [MRC Centre for Regenerative Medicine Press Release]

Mesoblast Update on Valeant Proposal to Cephalon
Mesoblast wishes to inform the market that the Board of its strategic partner Cephalon Inc. has rejected the unsolicited proposal from Valeant Pharmaceuticals International Inc. to acquire its issued share capital or certain assets. [Mesoblast Limited Press Release]

Announcing the First Stem Cell Translational Journal
AlphaMed Press announces the launch of a major peer-reviewed journal, STEM CELLS Translational Medicine, answering an acknowledged need within the research and clinical communities for comprehensive coverage of stem cell science, stem cell-based regenerative medicine and tissue engineering, stem cell-based predictive toxicology, and cancer stem cell investigation. [AlphaMed Press Press Release]


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW 2nd Else Kröner-Fresenius Symposium on Molecular Mechanisms of  Adult Stem Cell Aging
May 20-22, 2011
Günzburg, Germany

Visit our events page to see a complete list of events in the mesenchymal cell community.


Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Assistant Professor/Tissue Engineer (The University of Texas Medical School at Houston)

Experienced Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Paris Diderot)

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