Volume 3.15 | Apr 19

Mesenchymal Cell News 3.15, April 19, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Malignant Tumor Formation After Transplantation of Short-Term Cultured Bone Marrow Mesenchymal Stem Cells in Experimental Myocardial Infarction and Diabetic Neuropathy
The aim of the study was to investigate whether mesenchymal stem cells can treat experimental acute myocardial infarction and diabetic neuropathy. [Circ Res]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Intravenous Administration of Auto Serum-Expanded Autologous Mesenchymal Stem Cells in Stroke
Researchers report a study designed to assess feasibility and safety of transplantation of autologous human mesenchymal stem cells expanded in autologous human serum in stroke patients. [Brain]

The Use of Dynamic Surface Chemistries to Control MSC Isolation and Function
This paper defines the potential of –CH3 modified surfaces, with optimized dynamic surface chemistry, to manipulate initial mesenchymal stem cell (MSC) adhesive events, integrin binding, and subsequent cell function. [Biomaterials]

Simultaneous Regeneration of Articular Cartilage and Subchondral Bone In Vivo Using MSCs Induced by a Spatially Controlled Gene Delivery System in Bilayered Integrated Scaffolds
In the present study, researchers formulated a bilayered gene-activated osteochondral scaffold consisting of plasmid TGF-ß1-activated chitosan-gelatin scaffold for chondrogenic layer and plasmid BMP-2-activated hydroxyapatite/chitosan-gelatin scaffold for osteogenic layer. [Biomaterials]

Relative Percentage and Zonal Distribution of Mesenchymal Progenitor Cells in Human Osteoarthritic and Normal Cartilage
The present results underline the suitability of CD166 as a biomarker to identify and, in particular, localize and/or enrich resident mesenchymal progenitor cells with a high chondrogenic potential in human articular cartilage. [Arthritis Res Ther]

Fetal Liver-Derived Mesenchymal Stem Cell Engraftment After Allogeneic In Utero Transplantation into Rabbits
Researchers report safe and widespread distribution of recombinant pSF-EGFP retrovirus-transduced fetal rabbit liver mesenchymal stem cells in neonatal rabbit tissues at 10 days after fetal allogeneic transplantation through both intrahepatic and intra-amniotic administration. [Stem Cells Dev]

Adipogenic Differentiation of Individual Mesenchymal Stem Cell on Different Geometric Micropatterns
Human mesenchymal stem cells were cultured on the micropatterned surface, and the effect of cell geometry on adipogenic differentiation was investigated. [Langmuir]

Effective Treatment of Severe Steroid-Resistant Acute Graft-Versus-Host Disease with Umbilical Cord-Derived Mesenchymal Stem Cells
Researchers compared umbilical cord-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells for morphology, surface markers expression, differentiation, proliferative potential, and their suppressive effects on peripheral blood mononuclear cell proliferation. [Transplantation]

Mixture of Fibroblasts and Adipose Tissue-Derived Stem Cells Can Improve Epidermal Morphogenesis of Tissue-Engineered Skin
The findings revealed for the first time that a mixture of fibroblasts and adipose tissue-derived stem cells in bilayered tissue-engineered skin can improve epidermal morphogenesis. [Cells Tissues Organs]

Multipotent Mesenchymal Stromal Cells Express FoxP3: A Marker for the Immunosuppressive Capacity?
Regulatory T lymphocytes  and mesenchymal stromal cells have immunosuppressive features in common. Here, researchers looked for a common basis for immunosuppression in these distinct cell types. [J Immunother]

Investigating the Role of Hematopoietic Stem and Progenitor Cells in Regulating the Osteogenic Differentiation of Mesenchymal Stem Cells In Vitro
In this study, researchers investigated the influence of hematopoietic stem and progenitor cells on the osteogenic differentiation of mesenchymal stem cells in vitro, using a highly enriched population of hematopoietic cells with the phenotype c-Kit+Sca-1+Lineage- and bone marrow derived mesenchymal stromal cells in direct contact co-culture in medium with or without the addition of the osteogenic supplement dexamethasone. [J Orthop Res]

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INDUSTRY NEWS

Osiris Therapeutics Wins Top Scoring Abstract at the 24th Annual Symposium on Advanced Wound Care
The abstract, “Characterization of novel human mesenchymal stem cell-containing skin substitutes for the treatment of wounds” by lead author Dr. Dana Yoo, was awarded the top score of all entries to the meeting as determined by a blinded review panel that evaluated submissions for their importance and relevance to the field of wound care research. [Osiris Therapeutics, Inc. Press Release]

Tissue Genesis Begins FDA-Approved Clinical Trial
Tissue Genesis, Inc., an emerging leader in adult stem cell and regenerative medicine, announced that it has begun clinical trials for peripheral vascular disease (PVD) with adipose (fat) derived adult stem cell-coated vascular grafts at the University of Louisville Hospital. [PR Newswire]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Discussion Workshop: Stem Cells
May 6, 2011
London, United Kingdom

NEW International Society for Cellular Therapy (ISCT) 17th Annual Meeting
May 18-21, 2011
Rotterdam, The Netherlands

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

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Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Assistant Professor/Tissue Engineer (The University of Texas Medical School at Houston)

Experienced Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Paris Diderot)

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