Volume 3.16 | Apr 26

Mesenchymal Cell News 3.16, April 26, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY

Strontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling
In this study, researchers investigated the effects of strontium on the osteogenic differentiation of human mesenchymal stem cells and its
related mechanism; its osteogenic potential was also evaluated using a calvarial defect model in rats. [Stem Cells]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Dissection of the Biphasic Nature of Hypoxia-Induced Motogenic Action in Bone Marrow-Derived Human Mesenchymal Stem Cells
In this study, designed to dissect mechanisms underlying hypoxia-dependent migration of bone marrow-derived human mesenchymal stem cells,
signal transduction and molecular mechanisms were evaluated by integrating morphological, molecular and cell biology techniques, including
the wound healing and modified Boyden’s chamber assays to monitor migration. [Stem Cells]

TLR-3-Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils
In this study, researchers aimed to assess whether Toll-like receptor (TLR)3- and TLR4-activated bone marrow-derived mesenchymal stromal cells
influence human neutrophil responses under coculture conditions. [Stem Cells]

Adipose Tissue-Derived Stem Cell In Vitro Differentiation in a Three-Dimensional Dental Bud Structure
Researchers show how mesenchyme-derived single stem cell populations can be induced to transdifferentiate in vitro in a structure
similar to a dental bud. [Am J Pathol]

Adipose Injury–Associated Factors Mitigate Hypoxia in Ischemic Tissues through Activation of Adipose-Derived Stem/Progenitor/Stromal Cells and Induction of Angiogenesis
The results suggest that adipose injury cocktail may have therapeutic potentials for various ischemic/hypoxic conditions by inducing adipose remodeling and neovascularization through activation of adipose-derived stem/progenitor/stromal cells and other cells. [Am J Pathol]

Contamination of Mesenchymal Stem-Cells with Fibroblasts Accelerates Neurodegeneration in an Experimental Model of Parkinson’s Disease
Here researchers show for the first time, using the same experimental model and protocol, that transplantation of umbilical cord-derived
mesenchymal stem cells induced potent neuroprotection in the brain resulting in clinical benefit. [Stem Cell Rev]

Aligned Hybrid Silk Scaffold for Enhanced Differentiation of Mesenchymal Stem Cells into Ligament Fibroblasts
The results show that the aligned hybrid scaffold system is promising for enhancing cell proliferation, differentiation, and function for
ligament tissue engineering applications. [Tissue Eng Part C Methods]

Isolation and Characterization of Mesenchymal Stem Cells (MSCs) from the Fat Layer on the Density Gradient Separated Bone Marrow
In the present study researchers presented evidences that MSCs could be isolated from the very low-density cells of the fat layer. [Stem
Cells Dev]

Chemokines Stimulate Bi-Directional Migration of Human Mesenchymal Stem Cells Across Bone Marrow Endothelial Cells
Here researchers describe the migratory cues that drive mesenchymal stem cell transendothelial migration in both directions with focus on
chemokines. [Stem Cells Dev]

PDX1- and NGN3-Mediated In Vitro Reprogramming of Human Bone Marrow-Derived Mesenchymal Stromal Cells (BM-MSC) into Pancreatic Endocrine Lineages
Reprogramming primary BM-MSC into pancreatic endocrine lineages has not yet been consistently demonstrated. To unravel the role and interaction of key factors governing this process, researchers used well-characterized telomerase-immortalized human MSC (hMSC-TERT). [Cytotherapy]

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INDUSTRY NEWS

Scientific Community Leaders Meet May 2 to Begin Advising NIH’s Center for Scientific Review
Scientific experts from across the country have joined a new council that will begin meeting May 2, 2011, to advise the Center for Scientific Review (CSR) at the National Institutes of Health on the peer review of NIH grant applications in scientific review groups at CSR. [National Institutes of Health Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 2011 World Stem Cell Summit
October 3-5, 2011
Pasadena, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Assistant Professor/Tissue Engineer (The University of Texas Medical School at Houston)

Experienced Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Paris Diderot)

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