Volume 3.17 | May 3

Mesenchymal Cell News 3.17, May 3, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY

Inhibition of Cellular Senescence by Developmentally Regulated FGF-Receptors in Mesenchymal Stem Cells
Because FGFs play key roles in bone development and their receptors are developmentally regulated in bones, researchers here hypothesized that mesenchymal stem cells should express FGF-receptors reflecting their developmental origin and potential. [Blood]

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SCIENCE NEWS

Extracting Stem Cells from Fat for Tissue Regeneration
An interdisciplinary team of Queen’s University researchers led by Dr. Lauren Flynn has been working with stem cells extracted from samples of human fat and is developing new methods in the lab to develop these cells into mature tissue substitutes. [Queen’s University Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Targeted Methylation of Two Tumor Suppressor Genes is Sufficient to Transform Mesenchymal Stem Cells into Cancer Stem/Initiating Cells 
In this study, researchers used a novel targeted DNA methylation technique to methylate the promoters of HIC1 and RassF1A, two well-established tumor suppressor genes, along with a two-component reporter system to visualize successful targeting of human bone marrow-derived mesenchymal stem cells as a model cell system. [Cancer Res]

Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells
Here researchers show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells and accelerates their specific differentiation into bone cells. [ACS Nano]

Delivery of Gelfoam-Enabled Cells and Vectors Into the Pericardial Space Using a Percutaneous Approach in a Porcine Model
In a porcine model of myocardial infarction (MI), researchers deployed gelfoam particles carrying either (a) autologous mesenchymal stem cells or (b) an adenovirus encoding enhanced green fluorescent protein (eGFP) 48 h post-MI. [Gene Ther]

Continuous Cyclic Mechanical Tension Inhibited Runx2 Expression in Mesenchymal Stem Cells through RhoA-ERK1/2 Pathway
The results indicate that the inhibition of Runx2 expression after continuous cyclic mechanical tension (CCMT) stimulation is mediated by RhoA-ERK1/2 pathway. [J Cell Physiol]

Role of the EGFR Ligand/Receptor System in the Secretion of Angiogenic Factors in Mesenchymal Stem Cells
Since the majority of carcinomas secrete ligands of the epidermal growth factor receptor (EGFR), researchers assessed the role of EGFR signaling in regulating the release of angiogenic factors in mesenchymal stem cells. [J Cell Physiol]

Mesenchymal Progenitor Cells from Canine Fetal tissues: Yolk Sac, Liver and Bone Marrow
The objectives of this study were to isolate and characterize mesenchymal progenitor cells from canine yolk sac, bone marrow and liver in early and late stages of fetal development. [Tissue Eng Part A]

Paracrine Effects Influenced by Cell Culture Medium and Consequences on Microvessel-Like Structures in Co-Cultures of Mesenchymal Stem Cells and Outgrowth Endothelial Cells
In this study the formation of angiogenic structures in vitro was investigated in co-cultures of mesenchymal stem cells (MSC) and outgrowth endothelial cells (OEC), cultured either in the medium for osteogenic differentiation of MSC or in the medium for OEC cultivation (EGM2 Bullet Kit). [Tissue Eng Part A]

Differential Proteome Analysis of Bone Marrow Mesenchymal Stem Cells from Adolescent Idiopathic Scoliosis Patients
In this study, researchers utilized two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with mass spectrometry to analyze the differential proteome of bone marrow mesenchymal stem cells from adolescent idiopathic scoliosis (AIS) patients. [PLoS ONE]

In Vitro Concurrent Endothelial and Osteogenic Commitment of Adipose-Derived Stem Cells and Their Genomical Analyses through CGH Array: Novel Strategies to Increase the Successful Engraftment of a Tissue Engineered Bone Grafts
The aim of the present work was to investigate how the co-commitment into a vascular and bone phenotype of adipose-derived stem cells could be a useful tools for improving the in vitro and in vivo reconstruction of a vascularized bone graft. [Stem Cells Dev]

Matrix-Associated Implantation of Predifferentiated Mesenchymal Stem Cells Versus Articular Chondrocytes: In Vivo Results of Cartilage Repair After 1 Year
Researchers hypothesized that chondrogenic in vitro predifferentiation of autologous mesenchymal stem cells embedded in a collagen I hydrogel leads to better structural repair of a chronic osteochondral defect in an ovine stifle joint after 1 year. [Am J Sport Med]

INDUSTRY NEWS

Cytori Appoints Tommy G. Thompson to its Board; Names Lloyd Dean Chairman
On April 28, 2011, Cytori Therapeutics elected the Honorable Tommy G. Thompson, former Secretary of the US Department of Health & Human Services and Governor of Wisconsin, as an independent member of Cytori’s Board of Directors. [Cytori Therapeutics Press Release]

Stanford Creates First PhD Program in Stem Cell Science
Stanford University’s Faculty Senate approved the creation of what officials believe is the first PhD program devoted solely to stem cell science in the nation and, perhaps, the world. The new doctoral program in stem cell biology and regenerative medicine is also the first interdisciplinary doctoral program created by the School of Medicine in recent years. [Stanford University Press Release]

California Ponders Cell-Banking Venture
Investigators creating a wealth of adult-derived stem-cell lines may soon get new banks for storing them. [California Institute for Regenerative Medicine, United States]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Stem Cells USA & Regenerative Medicine Congress 2011
September 12-15, 2011
Boston, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Assistant Professor/Tissue Engineer (The University of Texas Medical School at Houston)

Experienced Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Paris Diderot)


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