Volume 3.19 | May 17

Mesenchymal Cell News 3.19, May 17, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY

Human Umbilical Mesenchymal Stem Cells Promote Recovery After Ischemic Stroke
Here researchers evaluate the therapeutic potential of human umbilical mesenchymal stem cell transplantation for ischemic stroke in rats. [Stroke]

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SCIENCE NEWS

Stem Cells from Bone Marrow May Help Treat Acute Lung Injury
New research investigates the therapeutic use of human stem cells from bone marrow against acute lung injury and identifies TNF-α-induced protein 6 as a major molecular component of stem cell action. [Press release from ScienceDaily discussing online prepublication in Stem Cell Research & Therapy]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Zoledronic Acid Blocks the Interaction between Mesenchymal Stem Cells and Breast Cancer Cells: Implications for Adjuvant Therapy of Breast Cancer
Zoledronic acid (ZA) reduces locoregional and distant metastases in estrogen receptor-positive breast cancer patients. Since ZA rapidly concentrates in the bone following i.v. administration, researchers hypothesized that this phenomenon involves the mechanism of action of ZA in bone tissue. [Ann Oncol]

Gene Regulation Of Extracellular Matrix Remodeling In Human Bone Marrow Stem Cell – Seeded Tissue Engineered Grafts
Researchers hypothesize that cell-scaffold interaction and mechanical deformation results in upregulation of genes related to osteogenic/chondrogenic differentiation and thus changes extracellular matrix composition in human bone marrow mesenchymal stem cells derived tissue engineered grafts. [Tissue Eng Part A]

The Effect of Mesenchymal Stromal Cell – Hyaluronic Acid Hydrogel Constructs on Immunophenotype of Macrophages
Researchers investigated the effect of mesenchymal stromal cells on immunophenotype of macrophages in the presence of an hyaluronic acid – hydrogel scaffold using a unique 3D coculture system. [Tissue Eng Part A]

The Effect of Mesenchymal Stem Cell Osteoblastic Differentiation on the Mechanical Properties of Engineered Bone-like Tissue
Here researchers hypothesized that mesenchymal stem cell osteoblastic differentiation and maturation can be supported by three-dimensional cultures in collagen hydrogels (hydrogel-culture) to ultimately give rise to mechanically robust bone-like tissue. [Tissue Eng Part A]

Fate of Bone Marrow Stromal Cells in a Syngenic Model of Bone Formation
The aim of the present work was to use sensitive and quantitative methods to track donor and recipient cells after implantation of BMSCs in a syngenic model of ectopic bone formation. [Tissue Eng Part A]

Transduction of Human Adipose-Derived Mesenchymal Stem Cells by Recombinant Adeno-Associated Virus Vectors
This study reports the efficient transduction of well characterized, homogeneous cultures of human adipose-derived stem cells by recombinant adeno-associated virus serotypes 2, 5, and 6. [Tissue Eng Part C Methods]

Detecting and Targeting Mesenchymal-Like Subpopulations within Squamous Cell Carcinomas
The results demonstrate that mesenchymal-like squamous cell carcinoma cells, which resist current chemotherapies, respond to a treatment strategy developed against a stem-like subset in breast carcinoma. [Cell Cycle]

Hypoxic Preconditioning Enhances Bone Marrow Mesenchymal Stem Cell Migration via Kv2.1 Channel and FAK Activation
Based on recent observations that hypoxic preconditioning (HP) has multiple benefits in improving stem cell therapy and that the potassium Kv2.1 channel acts as a promoter for focal adhesion kinase (FAK) activation and cell motility, the present investigation tested the hypothesis that HP treatment can increase bone marrow mesenchymal stem cell migration via the mechanism of increased Kv2.1 expression and FAK activities. [Am J Physiol Cell Physiol]

Mesenchymal Stem Cells Facilitate Mixed Hematopoietic Chimerism Induction and Prevent Onset of Diabetes in Nonobese Diabetic Mice
Allogeneic mesenchymal stem cells and bone marrow cells were cotransplanted in nonobese diabetic mice after none myeloablative preconditioning and the development of chimerism, insulitis, diabetes, and graft-versus-host disease were monitored. [Pancreas]

Human Multipotent Stromal Cells Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice via Secretion of Tumor Necrosis Factor-Alpha-Induced Protein 6
To better understand how human multipotent stromal cells (hMSCs) may act in acute lung injury, the lungs of immunocompetent mice were exposed to lipopolysaccharide and four hours later bone marrow derived hMSCs were delivered by oropharyngeal aspiration. [Stem Cell Res Ther]

INDUSTRY NEWS

Cellzome to Study Epigenetic Factors with Neusentis
Cellzome announced a joint project with Pfizer’s Pain & Sensory Disorders and Regenerative Medicine unit ‘Neusentis’, to characterize epigenetic factors involved in stem cell differentiation using Cellzome’s Episphere™ technology. The aim of the project is to shed light on the epigenetic mechanisms involved in the regulation of stem cell differentiation. [Cellzome Press Release]

Stem Cell Standardization Deal Inked Between New Players Sistemic and Leaders Roslin Cells
Sistemic Ltd and Roslin Cells Ltd signed a Memorandum of Understanding to promote the development of new technologies for the standardization of the manufacture of stem cells for their use in cell therapy and drug development screening. [Sistemic Ltd. Press Release]

Shire on Hunt for Assets in Stem Cells, Genetics
British drugmaker Shire Plc would like to acquire experimental products derived from stem cells, but the company’s chief executive said it is hard to find assets that are likely to make money. [Reuters]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Stem Cell Biology
September 20-24, 2011
Cold Spring Harbor, United States

Visit
our events page to see a complete list of events in the mesenchymal cell community.
JOB OPPORTUNITIES

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Assistant Professor/Tissue Engineer (The University of Texas Medical School at Houston)

Experienced Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Paris Diderot)

Post Doctoral Research Assistant (Department of Chemistry, University of Oxford)


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