Volume 3.25 | Jun 28

Mesenchymal Cell News 3.25, June 28, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY
Transformation of Human Mesenchymal Cells and Skin Fibroblasts into Hematopoietic Cells
To determine whether non-hematopoietic cells can be reprogrammed into hematopoietic cells, human mesenchymal stem cells and skin fibroblasts were incubated with the demethylating agent 5-azacytidine and the growth factors granulocyte-macrophage colony-stimulating factor and stem cell factor. [PLoS One]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

3D-Spheroid Culture of Human Gingiva-Derived Mesenchymal Stem Cells Enhances Mitigation of Chemotherapy-Induced Oral Mucositis
Researchers report a 3D-spheroid culture approach to optimize stem cell properties and therapeutic effects of human gingiva-derived mesenchymal stem cells in mitigation of experimental oral mucositis. [Stem Cells Dev]

PEDF and MDA-7 Cytokine Gene Therapies Delivered by Adipose-Derived Mesenchymal Stem Cells are Effective in Reducing Prostate Cancer Cell Growth
The goal was to examine the potential of adipose-derived mesenchymal stem cells to deliver cytokine gene therapies melanoma differentiation associated gene-7 (MDA-7) or pigment epithelial-derived factor (PEDF) to cancer cells. [Stem Cells Dev]

Controlling the Fibroblastic Differentiation of Mesenchymal Stem Cells via the Combination of Fibrous Scaffolds and Connective Tissue Growth Factor

The goal of the current study was to define experimental parameters that can be used to control the initial fibroblastic differentiation of mesenchymal stem cells in vitro. [Tissue Eng Part A]


An Improved Transplantation Strategy for Mouse Mesenchymal Stem Cells in an Acute Myocardial Infarction Model

To develop an effective therapeutic strategy for cardiac regeneration using bone marrow mesenchymal stem cells (BM-MSCs), the primary mouse BM-MSCs (1st BM-MSCs) and 5th passage BM-MSCs from β-galactosidase transgenic mice were respectively intramyocardially transplanted into the acute myocardial infarction model of wild type mice. [PLoS One]

Mesenchymal Stem Cell Injection Ameliorates Chronic Renal Failure in a Rat Model
Researchers evaluated the effect of mesenchymal stem cells in the progression of chronic kidney disease and the expression of molecular biomarkers associated with regenerative effects. [Clin Sci]


Intrapulmonary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Attenuates Acute Lung Injury by Expanding CD4CD25+ Forkhead Boxp3 (FOXP3)+ Regulatory T Cells and Balancing Anti- and Pro-inflammatory Factors
The present study was designed to determine whether human umbilical cord mesenchymal stem cells are able to act on CD4+CD25+ Foxp3+Treg cells and lead to an improvement in acute lung injury. [Cell Physiol Biochem]

Transplantation of Flk-1+ Human Bone Marrow-Derived Mesenchymal Stem Cells Promotes Angiogenesis and Neurogenesis after Cerebral Ischemia in Rats
Researchers examined whether bone marrow-derived mesenchymal stem cell-induced angiogenesis enhances cerebral tissue perfusion and creates a suitable microenvironment within the ischemic brain, which in turn accelerates endogenous neurogenesis and leads to improved functional recovery. [Eur J Neurosci]

Isolation and Cellular Properties of Mesenchymal Cells Derived from the Decidua of Human Term Placenta
Researchers isolated plastic-adherent cells from human term decidua vera, called decidua-derived-mesenchymal cells, and compared their properties with those of bone marrow-derived-mesenchymal stem cells. [Differentiation]


Genetically-Modified Pig Mesenchymal Stromal Cells: Xenoantigenicity and Effect on Human T-Cell Xenoresponses
Mesenchymal stromal cells from wild-type, α1,3-galactosyltransferase gene knockout (GTKO) and GTKO pigs transgenic for the human complement-regulatory protein CD46 were isolated and tested for differentiation. [Xenotransplantation]

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INDUSTRY NEWS

Bond Financier Elected to Chair California Stem Cell Agency
The California Institute for Regenerative Medicine has elected southern California investor Jonathan Thomas to be its next chair. [California Institute for Regenerative Medicine Press Release]

UC Davis Clinical and Translational Science Center Receives Renewed Grant Funding
The University of California (UC) Davis Clinical and Translational Science Center received renewed grant funding of $20 million from the National Center for Research Resources. [University of California, Davis Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Cancer Research Global Summit 
August 16-17, 2011 
London, United Kingdom 

Visit our events page to see a complete list of events in the mesenchymal cell community.
JOB OPPORTUNITIES

Chemist (STEMCELL Technologies)

Research and Development Senior Technologist (STEMCELL Technologies)

Lab Technologist – Tissue Culture (Maternity Leave) (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Lab Technician (Tissue Regeneration Therapeutics, Inc.)

Postdoctoral Research Fellow (Tshwane University of Technology)

Industrial Postdoctoral Research Fellow – Regenerative Medicine Cell Therapy (Tissue Regeneration Therapeutics Inc.)

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