Volume 3.26 | Jul 5

Mesenchymal Cell News 3.26, July 5, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY
Resveratrol Promotes Osteogenesis of Human Mesenchymal Stem Cells by Up-Regulating RUNX2 Gene Expression via SIRT1/FOXO3A Axis
In this study, researchers investigated the molecular mechanism of how resveratrol can modulate the lineage commitment of human mesenchymal stem cells to osteogenesis other than adipogenesis. [J Bone Miner Res]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Stimulation of Osteogenic Differentiation of Human Adipose-Derived Stem Cells by Ionic Products from Akermanite Dissolution via Activation of the ERK Pathway
Researchers investigated the effect of the extract from akermanite, on proliferation and osteogenic differentiation of human adipose-derived stem cells. [Biomaterials]

A Comparative Study of Neural and Mesenchymal Stem Cell-Based Carriers for Oncolytic Adenovirus in a Model of Malignant Glioma
In this study, researchers evaluated neural stem cells and mesenchymal stem cells as cellular delivery vehicles for an oncolytic adenovirus in the context of human glioma. [Mol Pharm]

Mesenchymal Stem Cell Inhibition of T-Helper 17 Differentiation is Triggered by Cell-Cell Contact and Mediated by Prostaglandin E2 via the EP4 Receptor
Mesenchymal stem cell influence on the differentiation of naïve and memory CD4+ T cells toward the T-helper 17 phenotype was examined. [Eur J Immunol]

Favorable Response of Chronic Refractory Immune Thrombocytopenic Purpura to Mesenchymal Stem Cells
Seven patients with chronic refractory immune thrombocytopenic purpura received adipose tissue-derived mesenchymal stem cells from haplo-identical family donors. [Stem Cells Dev]

Wnt/β-Catenin Signaling Induces the Aging of Mesenchymal Stem Cells through the DNA Damage Response and the p53/p21 Pathway
In the current study, researchers examine the effects of old rat serum (ORS) on the aging of mesenchymal stem cells (MSC), and explore the effects and mechanisms of Wnt/β-catenin signaling on MSC aging induced by ORS treatment. [PLoS One]

A Comparative Study of Induced Pluripotent Stem Cells Generated from Frozen, Stocked Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells
Researchers generated induced pluripotent stem cells from frozen-stocked adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells and examined their biological characteristics by comparative analyses. [J Tissue Eng Regen Med]

Phenotypic and Functional Characterization of Human Bone Marrow Stromal Cells in Hollow-Fibre Bioreactors
Researchers show that culturing human bone marrow stromal cells in a large-scale hollow-fibre bioreactor is feasible without deleterious effects on phenotype, thus providing a platform for collecting and delivering the paracrine secretions of these cells. [J Tissue Eng Regen Med]

Growth-Inhibitory Effect of Neurotrophin-3-Secreting Adipose Tissue-Derived Mesenchymal Stem Cells on the D283-MED Human Medulloblastoma Cell Line
The purpose of this study was to demonstrate in vitro biological effects of neurotrophins-3 (NT-3) on medulloblastoma cells and to evaluate the growth-inhibitory effect of NT-3-secreting stem cells on tumor cells. [J Neurooncol]

Cell Proliferation and Neuroblast Differentiation in the Rat Dentate Gyrus after Intrathecal Treatment with Adipose-Derived Mesenchymal Stem Cells
In the present study, researchers investigated the effects of adipose-derived mesenchymal stem cell transplantation via intrathecal injection through the cisterna magna on cell proliferation and differentiation of endogenous stem cells in the hippocampal dentate gyrus using Ki-67 and doublecortin. [Cell Mol Neurobiol]

Adipose-Derived Stromal Cells Cultured in a Low-Serum Medium, but not Bone Marrow-Derived Stromal Cells, Impede Xenoantibody Production
The aim of this study was to compare the action of low serum-cultured adipose-derived mesenchymal stromal cells (ASC), high serum-cultured ASC, and bone marrow-derived mesenchymal stromal cell, on xenoantibody production by B cells. [Xenotransplantation]

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INDUSTRY NEWS

United States FDA Clears Mesoblast Phase 2 Trial to Treat Degenerative Disc Disease

Mesoblast Limited announced that it has received clearance from the United States Food and Drug Administration (FDA) to begin a Phase 2 clinical trial of its proprietary adult Mesenchymal Precursor Cell product for the treatment of degenerative disc disease. [Mesoblast Limited Press Release]

Scripps Translational Science Institute Joins Jackson Laboratory’s National Tumor Consortium to Accelerate Targeted Cancer Therapies
The Scripps Translational Science Institute announced it has joined a national consortium of research institutions headed by The Jackson Laboratory that is building a library of primary human tumors with the goal of developing highly targeted cancer therapies. [The Scripps Research Institute Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 4th Annual Stem Cells Europe 
July 20-21, 2011
Edinburgh, Scotland 

NEW The EMBO Meeting 2011
September 10-13, 2011 
Vienna, Austria 

NEW The 2012 London Regenerative Medicine Event  
February 16, 2012 
London, United Kingdom

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Lab Technician (Tissue Regeneration Therapeutics, Inc.)

Postdoctoral Research Fellow (Tshwane University of Technology)

Industrial Postdoctoral Research Fellow – Regenerative Medicine Cell Therapy (Tissue Regeneration Therapeutics Inc.)

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