Volume 3.27 | Jul 12

Mesenchymal Cell News 3.27, July 12, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY
Human Ovarian Carcinoma-Associated Mesenchymal Stem Cells Regulate Cancer Stem Cells and Tumorigenesis via Altered Bone Morphogenetic Protein Production
In this study, researchers identified and confirmed the presence of carcinoma-associated mesenchymal stem cells in the majority of human ovarian tumor samples that they analyzed. [J Clin Invest]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
The Effect of Decellularized Bone/Bone Marrow Produced by High-Hydrostatic Pressurization on the Osteogenic Differentiation of Mesenchymal Stem Cells
In an animal study, when decellularized bone/bone marrows were implanted into the rat subcutaneous, no immune reaction occurred and clusters of the hematopoietic cells could be observed, suggesting the decellularized bone/bone marrows can provide a microenvironment in vivo. [Biomaterials]

A Novel Role for Neural Cell Adhesion Molecule in Modulating Insulin Signaling and Adipocyte Differentiation of Mouse Mesenchymal Stem Cells
In this study, researchers used bone-marrow-derived mesenchymal stem cells from wild-type and neural cell adhesion molecule (NCAM) knockout mice to investigate the role of NCAM in adipocyte differentiation. [J Cell Sci]

Human Adipose Tissue-Derived Mesenchymal Stem Cells Expressing Yeast Cytosinedeaminase::Uracil Phosphoribosyltransferase Inhibit Intracerebral Rat Glioblastoma
In this study, researchers tested the feasibility and efficacy of human adipose tissue-derived mesenchymal stem cells, engineered to express the suicide gene cytosine deaminase::uracil phosphoribosyltransferase to treat intracranial rat C6 glioblastoma. [Int J Cancer]

Immunological Aspects of Allogeneic and Autologous Mesenchymal Stem Cell Therapies
In the present study researchers examined whether NK cell mediated lysis of mesenchymal stem cells could be inhibited by immunosuppressive drugs. [Hum Gene Ther]

MicroRNA and Messenger RNA Analyses of Mesenchymal Stem Cells Derived from Teeth and the Wharton Jelly of Umbilical Cord
In this study, researchers integrated the use of microRNA and mRNA expression profiles to analyze human mesenchymal stem cells derived from Wharton’s jelly of the umbilical cord, milk teeth, and adult wisdom teeth. [Stem Cells Dev]

Decellularized Matrix from Tumorigenic Human Mesenchymal Stem Cells Promotes Neovascularization with Galectin-1 Dependent Endothelial Interaction
By exploring the heterogeneity in human mesenchymal stem cell-telomerase reverse transcriptase-20 clones researchers aimed to understand molecular mechanisms by which mesenchymal stem cells may promote neovascularization. [PLoS One]

Human Mesenchymal Stromal Cells Express CD14 Cross-Reactive Epitopes
Researchers detected binding of a CD14 antibody on bone marrow- and placenta-derived mesenchymal stem cells (MSCs) and investigated the staining of CD14 antibodies on these MSC in more detail. [Cytometry A]

Effects of Transplantation with Bone Marrow-Derived Mesenchymal Stem Cells Modified by Survivin on Experimental Stroke in Rats
This study was performed to determine whether injury induced by cerebral ischemia could be further improved by transplantation with bone marrow-derived mesenchymal stem cells modified by Survivin. [J Transl Med]

In Vivo MR Imaging Monitoring Nerve Regeneration of Acute Peripheral Nerve Traction Injury Following Mesenchymal Stem Cell Transplantation
The purpose of this study is to investigate in vivo MRI tracking mesenchymal stem cells in peripheral nerve injures using a clinically available paramagnetic contrast agent and commercially available rhodamine-incorporated transfection reagents. [J Magn Reson Imaging]

Isolation of Mouse Mesenchymal Stem Cells with Normal Ploidy from Bone Marrows by Reducing Oxidative Stress in Combination with Extracellular Matrix
Researchers tested the hypothesis that culture under low oxygen in combination with extracellular matrix (ECM) prepared from mouse embryonic fibroblast-ECM could be used to purify proliferative mouse mesenchymal stem cells, and to reduce oxidative damage and maintain their chromosomal stability. [BMC Cell Biol]

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INDUSTRY NEWS

Mesoblast Receives FDA Clearance for Phase III Bone Marrow Transplant Trial
Mesoblast Limited announced that it has received clearance from the United States Food and Drug Administration (FDA) to begin a Phase III clinical trial for bone marrow regeneration in patients with blood cancers. [Mesoblast Limited Press Release]

Ulster Joins International Alliance on Tissue Engineering Research
Scientists at the University of Ulster have joined a new international scientific alliance, working on the regeneration of human tissue and the growth of vital organs. [University of Ulster Press Release]

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW World Stem Cells and Regenerative Medicine Congress 2012 
May 14-16, 2012 
London, United Kingdom
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Research Fellow (Tshwane University of Technology)

Industrial Postdoctoral Research Fellow – Regenerative Medicine Cell Therapy (Tissue Regeneration Therapeutics Inc.)

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