Volume 3.32 | Aug 16

Mesenchymal Cell News 3.32, August 16, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY

Small Molecule-Based Disruption of the Axin/β-Catenin Protein Complex Regulates Mesenchymal Stem Cell Differentiation
The treatment of mesenchymal stem cells with SKL2001 promoted osteoblastogenesis and suppressed adipocyte differentiation, both of which were accompanied by the activation of Wnt/β-catenin pathway. [Cell Res]

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Current Publications (Ranked by Impact Factor of the Journal)

Effects of Hypoxias and Scaffold Architecture on Rabbit Mesenchymal Stem Cell Differentiation Towards a Nucleus Pulposus-Like Phenotype
In this study, three-dimensional nanofibrous poly(l-lactide) scaffolds were seeded with multi-potent rabbit mesenchymal stem cells and the constructs were induced along nucleus pulposus development routes in a hypoxia chamber (2% O2) in the presence of TGF-β1. [Biomaterials]

Chondrogenic Potential of Stem Cells Derived from Amniotic Fluid, Adipose Tissue, or Bone Marrow Encapsulated in Fibrin Gels Containing TGF-β3
In this study, several types of human mesenchymal stem cells, derived from bone marrow, adipose tissue, or amniotic fluid, were encapsulated in a fibrin hydrogel mixed with TGF-β3 and then evaluated for their capacity for differentiation in vitro and in vivo. [Biomaterials]

Immunological Aspects of Allogeneic and Autologous Mesenchymal Stem Cell Therapies
In the present study researchers examined whether natural killer cell-mediated lysis of mesenchymal stem cells could be inhibited by immunosuppressive drugs. [Hum Gene Ther]

The Influence of Hypoxia and Fibrinogen Variants on the Expansion and Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells
In this study, the influence of oxygen tension and naturally occurring fibrinogen variants on adipose tissue-derived mesenchymal stem cell expansion and differentiation were determined. [Tissue Eng Part A]

Change in Hepatocyte Growth Factor Concentration Promotes Mesenchymal Stem Cell-Mediated Osteogenic Regeneration
This study aimed to determine the mechanisms by which different concentrations of HGF regulate mesenchymal stem cell proliferation and osteogenic differentiation, and validate the mechanism in an animal model of early stage avascular necrosis of femoral head. [J Cell Mol Med]

Overexpression of Csx/Nkx2.5 and GATA-4 Enhances the Efficacy of Mesenchymal Stem Cell Transplantation After Myocardial Infarction
The aim of the present study was to investigate the effect of transplanting mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA-4 (MSCs-CG) after myocardial infarction. [Circ J]

Scaffold-Free Culture of Mesenchymal Stem Cell Spheroids in Suspension Preserves Multilineage Potential
In this study, mesenchymal stem cell spheroids, or “mesenspheres”, of different sizes, were formed using a forced aggregation technique and maintained in suspension culture for extended periods of time thereafter. [Cell Tissue Res]

Estrogen and Its Receptor Enhance Mechanobiological Effects in Compressed Bone Mesenchymal Stem Cells
To investigate the role of estrogen and its receptors in the mechanobiological effects in bone mesenchymal stem cells, isolated mesenchymal stem cells from bone marrow were exposed to mechanical pressure under additional estrogen treatment or estrogen receptor blockade. [Cells Tissues Organs]

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INDUSTRY NEWS

Mesoblast’s Heart Failure Trial Selected for Presentation in Special Session of American Heart Association Annual Conference
Global regenerative medicine company, Mesoblast Limited announced that its heart failure clinical trial has been chosen by the American Heart Association to be featured at its 2011 annual conference in Orlando, Florida, in the “Clinical Science: Special Reports” session on November 14. [Mesoblast Limited Press Release]

CI Awarded $1.86 Million Stem Cell Research Training Grant
California State University Channel Islands (CI) recently won a $1.86 million grant from the California Institute for Regenerative Medicine to help prepare graduate students for careers in stem cell research. [California State University Channel Islands Press Release]

GHSU Launches New Institute for Regenerative and Reparative Medicine
A new Institute for Regenerative and Reparative Medicine is working to help the body repair itself as it grows synergy between Georgia Health Sciences University (GHSU) and the community. [Georgia Health Sciences University Press Release]

apceth Is Granted a Manufacturer’s License for Somatic Cell Therapy
apceth is among the first companies in Germany to be granted a manufacturer’s license for the production of somatic cell therapeutics pursuant to Section 13, German Medicines Act. [B3C Newswire]

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW 4th Annual Maryland Stem Cell Research Symposium
October 6, 2011
Towson, United States
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Mesenchymal Stem Cell Fellowship (Universita’ Di Bologna)


Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)


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