Volume 3.33 | Aug 23

Mesenchymal Cell News 3.33, August 23, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY

Silica Nanorattle-Doxorubicin Anchored Mesenchymal Stem Cells for Tumor-Tropic Therapy
In this study, an efficient approach for tumor-targeted drug delivery was developed with mesenchymal stem cells as targeting vehicle and silica nanorattle as drug carrier. [ACS Nano]

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SCIENCE NEWS

Lasers Stimulate Stem Cells and Reduce Heart Scarring After Heart Attack, Study Suggests
Combining the therapeutic benefits of low-level lasers and bone marrow stem cells, researchers have developed an effective, non-invasive procedure that significantly reduces heart scarring after an ischemic event, in which the heart is injured by a lack of blood supply. [Press release from ScienceDaily discussing online prepublication in Lasers in Surgery and Medicine]

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Current Publications (Ranked by Impact Factor of the Journal)

Erythropoietin Gene-Enhanced Marrow Mesenchymal Stromal Cells Decrease Cisplatin-Induced Kidney Injury and Improve Survival of Allogeneic Mice
The study demonstrates that Epo gene-enhanced mesenchymal stromal cells exert significant tissue protective effects in allogeneic mice with acute kidney injury, and supports the potential use of gene-enhanced cells as universal donors in acute injury. [Mol Ther]


Hepatocellular Carcinoma Cells and Their Fibrotic Microenvironment Modulate Bone Marrow-Derived Mesenchymal Stromal Cell Migration In Vitro and In Vivo
The aim of this work was to analyze the capacity of human mesenchymal stromal cells to migrate and anchor to hepatocellular carcinoma tumors. [Mol Pharm]

14S,21R-Dihydroxy-Docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury
In this report, using a murine model of renal ischemia/reperfusion (I/R) injury, researchers found that treatment with 14S,21R-diHDHA enhanced mesenchymal stem cell amelioration of renal I/R injury. [Stem Cells Dev]

Periostin Mediates Human Adipose Tissue-Derived Mesenchymal Stem Cell-Stimulated Tumor Growth in a Xenograft Lung Adenocarcinoma Model
In the present study, researchers demonstrate that conditioned medium from A549 human lung adenocarcinoma cells induces expression of periostin, an extracellular matrix protein, in human adipose tissue-derived mesenchymal stem cells. [Biochim Biophys Acta]

Degenerate Wave and Capacitive Coupling Increase Human MSC Invasion and Proliferation While Reducing Cytotoxicity in an In Vitro Wound Healing Model
Researchers compared the effects of direct current, capacitive coupling, pulsed electromagnetic field and degenerate wave on cellular activities including cytotoxicity, proliferation, cell-kinetics and apoptosis by stimulating human-bone marrow mesenchymal stem cells 3 hours a day, up to 5 days. [PLoS ONE]

Optimized Conditions for Mesenchymal Stem Cells to Differentiate Into Osteoblasts on a Collagen/Hydroxyapatite Matrix
The study confirmed that a higher collagen content increased scaffold stiffness but that a greater stiffness was not sufficient for bone tissue formation, a complex process evidently also dependent on scaffold porosity. [J Biomed Mater Res A]

Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Cells in Collagen Scaffolds
Researchers compared the potential of bone marrow-derived mesenchymal stem cells and P19 embryonic carcinoma cells, a pluripotent derivative of embryonic stem cells, for cartilage histogenesis in porous collagen scaffolds in vitro. [J Biomed Mater Res A]

Induction of Autologous Mesenchymal Stem Cells in the Bone Marrow by Low-Level Laser Therapy has Profound Beneficial Effects on the Infarcted Rat Heart
In this study, researchers investigated the hypothesis that photobiostimulation of autologous bone-marrow-derived mesenchymal stem cells by low-level laser therapy applied to the bone marrow, may migrate to the infarcted area and thus attenuate the scarring processes following myocardial infarction. [Lasers Surg Med]

Effects of Mesenchymal Stem Cells on Matrix Metalloproteinase Synthesis in Cardiac Fibroblasts
This study investigated the effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts through paracrine actions. [Exp Biol Med]

GATA-4 Promotes Myocardial Transdifferentiation of Mesenchymal Stromal Cells via Up-Regulating IGFBP-4
Researchers investigated whether overexpression of GATA-4 increases adult mesenchymal stromal cell transdifferentiation into a cardiac phenotype in vitro. [Cytotherapy]

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INDUSTRY NEWS

First Minimally-Invasive Procedure Performed in Mesoblast’s Phase 2 Stem Cell Trial for Lumbar Disc Repair
Regenerative medicine company, Mesoblast Limited, announced that the first minimally-invasive lumbar disc procedure had been successfully performed in the Phase 2 clinical trial of its proprietary adult Mesenchymal Precursor Cell product for the treatment of low back pain and degenerative disc disease. [Mesoblast Limited Press Release]

apceth Starts First Phase I/II Clinical Study on Somatic Cell Therapy for Peripheral Arterial Occlusive Disease
The Munich biotech company apceth started its first phase I/II clinical study on somatic cell therapy for advanced peripheral arterial occlusive disease after angioplasty. [B3C Newswire]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Phacilitate Cell & Gene Therapy Forum 2012
January 30-February 1
Washington, United States
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Mesenchymal Stem Cell Fellowship (Universita’ Di Bologna)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

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