Volume 3.34 | Aug 30

Mesenchymal Cell News 3.34, August 30, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs 
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TOP STORY

Nuclear Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) Modulates Mesenchymal Cell Commitment and Differentiation
Here researchers show that inactivation of COUP-TFII, a member of the nuclear receptor superfamily, in mesenchymal progenitors favors osteoblast and myoblast development while simultaneously impairing adipogenic and chondrogenic programs. [Proc Natl Acad Sci USA] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Adhesion and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Titanium Nanopores
The adhesion and differentiation of mesenchymal stem cells were studied as a function of nanostructures. [Eur Cell Mater] Abstract

The Enhanced Performance of Bone Allografts Using Osteogenic-Differentiated Adipose-Derived Mesenchymal Stem Cells
To improve the osteogenicity of acellular bone allografts, adipose mesenchymal stem cells (AMSCs) and bone marrow MSCs (BM-MSCs) at nondifferentiated and osteogenic-differentiated stages were investigated in vitro and in vivo. [Biomaterials] Abstract

Core–Shell Cell Bodies Composed of Human cbMSCs and HUVECs for Functional Vasculogenesis
In the study, researchers used a thermo-responsive hydrogel system to fabricate core–shell cell bodies composed of cord-blood mesenchymal stem cells (cbMSCs) and human umbilical vascular endothelial cells (HUVECs) for functional vasculogenesis. [Biomaterials] Abstract

Bone Marrow Microenvironment in an In Vitro Model of Gaucher Disease: Consequences of Glucocerebrosidase Deficiency
In a chemical model of Gaucher Disease obtained with Conduritol ß epoxide, a specific inhibitor of glucocerebrosidase activity, researchers functionally characterized bone marrow mesenchymal stem cells and specifically analysed their capacity to differentiate into osteoblasts. [Stem Cells Dev] Abstract

Bone Marrow-Derived Mesenchymal Stromal Cells Enhance Chimeric Vessel Development Driven by Endothelial Cell Coated Microtissues
Adding bone marrow derived mesenchymal stromal cells (bmMSC) to endothelialized collagen gel modules resulted in mature vessel formation, presumably due in part to the observed display of pericyte-like behaviour for the transplanted GFP+ bmMSC. [Tissue Eng Part A] Abstract

Temporal and Spatial Changes in Cartilage-Matrix-Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression
The objective of this study was to determine the effect of dynamic compression on cartilage-matrix-specific gene expression and to relate this response to the local biochemical environment and cell phenotype at the time of loading. [Tissue Eng Part A] Abstract

Biomimetic ECM Incorporated Scaffold Induces Osteogenic Gene Expression in Human Marrow Stromal Cells
In this study, researchers have employed biomimetic strategies to develop a novel collagen/chitosan template that is incorporated with the native extracellular matrix (ECM) components of differentiating human marrow stromal cells. [Tissue Eng Part A] Abstract
 
Osteogenic Differentiation and Ectopic Bone Formation of Canine Bone Marrow-Derived Mesenchymal Stem Cells in Injectable Thermo-Responsive Polymer Hydrogel
This study describes an injectable, thermo-responsive hyaluronic acid-g-chitosan-g-poly(N-isopropylacrylamide) copolymer for bone tissue engineering. [Tissue Eng Part C Methods] Abstract

The Aging Effect of Chemotherapy on Cultured Human Mesenchymal Stem Cells
Human mesenchymal stem cells were assessed as target cells to investigate the initiation of the aging process by chemotherapy. [Exp Hematol] Abstract

Local Injections of Adipose-Derived Mesenchymal Stem Cells Modulate Inflammation and Increase Angiogenesis Ameliorating the Dystrophic Phenotype in Dystrophin-Deficient Skeletal Muscle
The effects of adipose-derived mesenchymal stem cells transplantation on degeneration, regeneration and skeletal muscle function were investigated in dystrophin-deficient mice (24-week-old). [Stem Cell Rev] Abstract

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INDUSTRY NEWS

Cleveland Researchers Collaborate to Launch Phase I Clinical Trial for New Multiple Sclerosis Treatment
A team of researchers at three landmark Cleveland institutions have come together to launch a new clinical trial of an experimental treatment for multiple sclerosis. [Cleveland Clinic] Press Release

UC Davis Awarded Five Therapy Development Stem Cell Grants
The California Institute for Regenerative Medicine approved research planning grants for five University of California, Davis (UC Davis) Health System teams that are working to develop human clinical trials to treat illnesses such as Huntington’s disease, vascular disease, osteoporosis, HIV/AIDS and airway disease in children. [University of California, Davis School of Medicine] Press Release

Mesoblast in Position of Considerable Strength
Regenerative medicine company, Mesoblast Limited, provided its full year financial results. The company stated that it had substantial funds of $263.2 million at 30 June 2011. [Mesoblast Limited] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW The New York Stem Cell Foundation Sixth Annual Translational Stem Cell Research Conference
October 11-12, 2011
New York, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Mesenchymal Stem Cell Fellowship (Universita’ Di Bologna)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

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