Volume 3.35 | Sep 6

Mesenchymal Cell News 3.35, September 6, 2011
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY

Autologous Mesenchymal Stem Cells Mobilize cKit+ and CD133+ Bone Marrow Progenitor Cells and Improve Regional Function in Hibernating Myocardium
The present study was conducted to test the hypothesis that mesenchymal stem cells mobilize bone marrow progenitor cells and improve function by stimulating myocyte proliferation in collateral-dependent hibernating myocardium. [Circ Res] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Here, researchers identify adipose precursor cells within the skin and demonstrate that their dynamic regeneration parallels the activation of skin stem cells. [Cell] Abstract | Press Release

The Effect of Synthetic Octacalcium Phosphate in a Collagen Scaffold on the Osteogenicity of Mesenchymal Stem Cells
Results indicate that octacalcium phosphate crystals in a collagen matrix efficiently promote exogenously introduced osteogenic cells to initiate bone regeneration if the cells are pre-treated in a suitable differentiation condition. [Eur Cell Mater] Abstract

Endurance Exercise Training Promotes Medullary Hematopoiesis
The purpose of this study was to directly investigate the effects of endurance exercise training on hematopoiesis and to identify potential mechanisms responsible for any observed changes. [FASEB J] Abstract | Press Release

Expression Patterns and Function of Chromatin Protein HMGB2 during Mesenchymal Stem Cell Differentiation
This study addressed HMGB2 expression patterns in mesenchymal stem cells and its role during differentiation. [J Biol Chem] Abstract

Human Dental Pulp Stem Cells Demonstrate Better Neural and Epithelial Stem Cell Properties than Bone Marrow-Derived Mesenchymal Stem Cells
To understand the characteristics of dental pulp stem cells from impacted third molar, proliferation capacities, gene expression profiles, phenotypic, ultrastructural, and differentiation characteristics were analyzed in comparison with human bone marrow-derived mesenchymal stem cells, extensively. [Histochem Cell Biol] Abstract

Expansion and Delivery of Adipose-Derived Mesenchymal Stem Cells on Three Microcarriers for Soft Tissue Regeneration
Scientists compared the suitability of fabricated micronized acellular dermal matrix, micronized small intestinal submucosa, and gelatin microspheres as expansion and delivery scaffolds for adipose-derived mesenchymal stem cells. [Tissue Eng Part A] Abstract

Human Mesenchymal Stem Cells Induced by Growth Differentiation Factor 5: An Improved Self-Assembly Tissue Engineering Method for Cartilage Repair
In this study, researchers generated self-assembled constructs of human mesenchymal stem cells (hMSCs) using four different approaches: direct self-assembly of hMSCs with or without GDF-5, and predifferentiated hMSCs self-assembly with or without GDF-5. [Tissue Eng Part C Methods] Abstract

Basement Membrane Collagen Type IV Expression by Human Mesenchymal Stem Cells during Adipogenic Differentiation
Results suggest that upon mesenchymal stem cell-adipocyte differentiation collagen type IV synthesis and remodelling become necessary when intracellular accumulation of fat necessitates a dynamically supporting and instructive, partly denatured adipogenic pericellular type IV collagen scaffold. [J Cell Mol Med] Abstract

Polybrene Inhibits Human Mesenchymal Stem Cell Proliferation during Lentiviral Transduction
As presented here, exposure to polybrene alone at commonly used concentratons (1–8 µg/mL) negatively impacts human mesenchymal stem cell proliferation in a dose-dependent manner as measured by CyQUANT, EdU incorporation, and cell cycle analysis. [PLoS ONE] Abstract

Electrospun Nanofiber-Based Regeneration of Cartilage Enhanced by Mesenchymal Stem Cells
The objective of this study was to investigate the potential of poly(vinyl alcohol)/polycaprolactone (PVA/PCL) nanofiber scaffolds seeded with rabbit bone marrow-mesenchymal stem cell for cartilage tissue engineering in vitro and in vivo. [J Biomed Mater Res A] Abstract

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SCIENCE NEWS
A Youthful Environment Can Rejuvenate Old Stem Cells
Several recent studies have shown that the mechanical properties of the matrix in which mesenchymal stem cells are grown can affect the type of cell they turn into. So researchers reasoned that the cell’s microenvironment might also influence its regenerative potential. [Press release from New Scientist discussing research presented at the Strategies for Engineered Negligible Senescence meeting in Cambridge, United Kingdom] Press Release
INDUSTRY NEWS

Mesoblast Receives Clearance to Begin First European Trial of Allogeneic or ‘Off-the-Shelf’ Stem Cell Treatment for Heart Attacks
Global regenerative medicine company, Mesoblast Limited, announced that it had received clearance from the European Medicines Agency to begin a 225-patient multi-center Phase 2 clinical trial in Europe for its lead cardiovascular product Revascor™ in conjunction with angioplasty and stent procedures to prevent heart failure after a major heart attack. [Mesoblast Limited] Press Release

CIRM Commits $1.8 Million to Build Stem Cell Teams, Accelerate New Therapies
The California Institute for Regenerative Medicine (CIRM) approved funding $1.8 million to support 19 researchers in their effort to assemble competitive teams to develop applications for the Disease Team Therapy Development Awards, which will be due in winter 2012. [California Institute for Regenerative Medicine] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Science: Stem Cell Imaging: Tips, Tricks & Best Practices
September 21, 2011
Webinar

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our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Mesenchymal Stem Cell Fellowship (Universita’ Di Bologna)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

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