Volume 3.38 | Sep 27

Mesenchymal Cell News 3.38, September 27, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs 
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TOP STORY

The i Blood Group Antigen as a Marker for Umbilical Cord Blood Derived Mesenchymal Stem Cells
Researchers have now studied in detail the cell surface expression of the blood group i epitope (linear poly-N-acetyllactosamine chain) in
umbilical cord blood derived mesenchymal stem cells. [Stem Cells Dev] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Cultured Cell-Derived Extracellular Matrix Scaffolds for Tissue Engineering
In this study, extracellular matrix scaffolds derived from mesenchymal stem cell, chondrocyte, and fibroblast were prepared by culturing cells in a selectively removable poly(lactic-co-glycolic acid) (PLGA) template. [Biomaterials] Abstract


Cationic Gd-DTPA Liposomes for Highly Efficient Labeling of Mesenchymal Stem Cells and Cell Tracking with MRI
In the current study cell labeling was performed with water soluble Gadolinium (Gd)-DTPA containing liposomes, to allow for cell tracking by MRI. Liposomes were used to assure a highly concentrated intracellular build up of Gd, aiming to overcome the relatively low MRI sensitivity of Gd (as compared to T2 contrast agents). [Cell Transplant] Abstract


Inhibitors of Tyrosine Phosphatases and Apoptosis Reprogram Lineage-Marked Differentiated Muscle to Myogenic Progenitor Cells
Here, researchers used the Cre-Lox method to specifically label postmitotic primary multinucleated myotubes and then utilized small molecule inhibitors of tyrosine phosphatases and apoptosis to dedifferentiate these myotubes into proliferating myogenic cells, without gene overexpression. [Chem Biol] Abstract | Press Release

Maintenance of Human Embryonic Stem Cells in Mesenchymal Stem Cell-Conditioned Media Augments Hematopoietic Specification
Here, researchers hypothesized that human embryonic stem cells (hESCs) maintained in human mesenchymal stem cell-conditioned media may be more prone to differentiation towards hematopoietic lineage than hESCs grown in standard human foreskin fibroblast-conditioned media. [Stem Cells Dev] Abstract


Intrinsic Growth Deficiencies of Mesenchymal Stromal Cells (MSCs) in Myelodysplastic Syndromes (MDS)
Herein, researchers present a novel selection protocol for obtaining a standards-compliant MSC preparation. [Stem Cells Dev] Abstract

Patterns of Amino Acid Metabolism by Proliferating Human Mesenchymal Stem Cells
In this study, researchers investigated the amino acid metabolism of human mesenchymal stem cells (hMSCs), with focus on two questions: Which amino acids are consumed and/or secreted by hMSCs and at what rates? [Tissue Eng Part A] Abstract

Forskolin Enhances In Vivo Bone Formation by Human Mesenchymal Stromal Cells
Data shows forskolin as a novel agent that can be used to increase bone formation and also suggests a role for protein kinase A in the delicate balance between adipogenic and osteogenic differentiation. [Tissue Eng Part A] Abstract

Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice
Researchers examined whether bone marrow-derived adherent stromal cell transplantation could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome. [PLoS ONE] Abstract

Transcriptome Analysis of MSC and MSC-Derived Osteoblasts on Resomer® LT706 and PCL: Impact of Biomaterial Substrate on Osteogenic Differentiation
In the present study, researchers analysed two synthetic, long-term degradable polymers for their impact on mesenchymal stem cell-based bone tissue engineering: PLLA-co-TMC (Resomer® LT706) and poly(ε-caprolactone) (PCL). [PLoS ONE] Abstract

The Combination of Angiotensin II and 5-Azacytidine Promotes Cardiomyocyte Differentiation of Rat Bone Marrow Mesenchymal Stem Cells
In this study, researchers investigated the effects of angiotensin II on the proliferation and differentiation of bone marrow mesenchymal stem cells induced by 5-aza in vitro. [Mol Cell Biochem] Abstract

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INDUSTRY NEWS

Three U-M Researchers Named 2011 MacArthur Fellows
Three University of Michigan (U-M) researchers are among the 22 new MacArthur Fellows announced by the John D. and Catherine T. MacArthur Foundation. [University of Michigan Health System] Press Release

NIH Announces 79 Awards to Encourage Creative Ideas in Science
The National Institutes of Health announced that it is awarding $143.8 million to challenge the status quo with innovative ideas that have the potential to propel fields forward and speed the translation of research into improved health for the American public. [National Institutes of Health] Press Release

Three UC Davis Researchers Win Prestigious NIH Awards
The National Institutes of Health (NIH) named three University of California (UC) Davis researchers recipients of highly competitive awards designed to encourage innovative, high-risk research and accelerate the translation of science into improved health. [University of California, Davis] Press Release

BrainStorm Receives Grant from Israel’s Office of the Chief Scientist
BrainStorm Cell Therapeutics Inc. announced that it received notice from Israel’s Office of the Chief Scientist (OCS) of its commitment to grant the Company approximately $1.1 million (NIS 3.8 million) in accordance with OCS requirements. [BrainStorm Cell Therapeutics Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Stem Cells in Drug Discovery and Development Conference
November 2-3, 2011
San Diego, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)


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