Volume 3.41 | Oct 18

Mesenchymal Cell News 3.41, October 18, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs 
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TOP STORY
Therapeutic Potential of a Distinct Population of Human Amniotic Fluid Mesenchymal Stem Cells and Their Secreted Molecules in Mice with Acute Hepatic Failure
Amniotic fluid-mesenchymal stem cells (AF-MSCs), hepatic progenitor-like cells and hepatocyte-like cells derived from AF-MSCs were transplanted into CCl4-injured NOD/SCID mice with the acute hepatic failure phenotype in order to evaluate their therapeutic potential. [Gut] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Composition of the Mesenchymal Stromal Cell Compartment in Human Bone Marrow Changes During Development and Aging
Researchers show that CD271 and CD146 define distinct colony-forming-unit-fibroblast containing mesenchymal stromal cell subpopulations. [Haematologica] Abstract

Human Amniotic Fluid-Derived Mesenchymal Stem Cells As Therapeutic Vehicles: A Novel Approach For the Treatment of Bladder Cancer
In this study, researchers document the great potential of amniotic fluid-derived mesenchymal stem cells as anti-cancer vehicles, implemented by the targeting of the tumor site and further facilitated by their high proliferation rate and expansion efficiency in culture. [Stem Cells Dev] Abstract

Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis
Researchers investigated whether the expression of scleraxis can lead to the direct commitment of mesenchymal stem cells into tendon progenitors. [Stem Cells Dev] Abstract

Effects of Glucocorticoid Receptor siRNA Delivered by Poly Lactic-Co-Glycolic Acid (PLGA) Microparticles on Proliferation and Differentiation Capabilities of Human Mesenchymal Stromal Cells
This study investigated the effects of the blockage of endogenous glucocorticoids using glucocorticoid receptor small interfering RNA (siRNA) delivered by biodegradable PLGA microparticles on proliferation and differentiation capabilities of human mesenchymal stem cells in vitro. [Tissue Eng Part A] Abstract

Towards an In Vitro Vasculature: Differentiation of Mesenchymal Stromal Cells Within an Endothelial Cell-Seeded Modular Construct in a Microfluidic Flow Chamber
Researchers suggest that mesenchymal stem cell embedded modules may be useful for the formation of functional vasculature in tissue engineered constructs. [Tissue Eng Part A] Abstract

Pullulan Hydrogels Improve Mesenchymal Stem Cell Delivery into High-Oxidative-Stress Wounds
Researchers show that pullulan hydrogels are an effective cell delivery system and improve mesenchymal stem cell survival and engraftment in high-oxidative-stress environments. [Macromol Biosci] Abstract

MRI of the Proximal Femur Predicts Marrow Cellularity and the Number of Mesenchymal Stem Cells
The purpose of this study was to determine whether the marrow conversion index in MRI is related to the total number of mononuclear and mesenchymal stem cells in proximal femoral metaphysis of patients with hip osteoarthritis. [J Magn Reson Imaging] Abstract

Age-Related Changes in Rat Bone-Marrow Mesenchymal Stem Cell Plasticity
In this study, researchers demonstrated that the expression profile of stemness markers was altered in bone-marrow mesenchymal stem cells derived from old rats. [BMC Cell Biol] Abstract

Imatinib Inhibits Proliferation of Human Mesenchymal Stem Cells and Promotes Early but Not Late Osteoblast Differentiation In Vitro
In this study osteoblast differentiation was induced in human mesenchymal stem cells by treatment with bone morphogenetic protein 2 in vitro. [J Bone Miner Metab] Abstract

Neurotrophin-3 Gene Modified Mesenchymal Stem Cells Promote Remyelination and Functional Recovery in the Demyelinated Spinal Cord of Rats
Researchers show that implantation of neurotrophin-3 gene-modified mesenchymal stem cells via a recombinant adenoviral vector into a region of ethidium bromide-induced demyelination in the spinal cord resulted in significant improvement of locomotor function and restoration of electrophysiological properties in rats. [J Neurol Sci] Abstract

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INDUSTRY NEWS

Maryland Stem Cell Research Commission Issues Requests for Applications
Per the Maryland Stem Cell Commission (Commission) meeting on Sept.15, 2010, the Commission has issued three official Requests for Applications for funding through the Maryland Stem Cell Research Fund under the Maryland Stem Cell Research Act. [Maryland Stem Cell Research Fund] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Select Biosciences STEMCELLS 2012 
February 2-3, 2012 
San Diego, United States 

NEW 7th Annual Stem Cell Summit 2012
February 21, 2012 
New York, United States 

NEW American Association for Cancer Research Annual Meeting 2012 
March 31-April 4, 2012 
Chicago, United States 

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

Postdoctoral Research Assistant Grade 7 (University of Oxford)

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