Volume 3.43 | Nov 1

Mesenchymal Cell News 3.43, November 1, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs 
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TOP STORY
p53 Activation of Mesenchymal Stromal Cells Partially Abrogates Microenvironment-Mediated Resistance to FLT3 Inhibition in AML through HIF-–Mediated Down-Regulation of CXCL12
Researchers investigated the role of p53 in bone marrow stromal cells in stromal cell-mediated resistance to Fms-like tyrosine kinase-3 (FLT3) inhibition in FLT3 mutant acute myeloid leukemia (AML). [Blood] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

SIRT1 Is Required for Long-Term Growth of Human Mesenchymal Stem Cells
In this study, researchers find that NAD-dependent protein deacetylase SIRT1 is differentially expressed in both human bone marrow-derived mesenchymal stem cells and adipose tissue-derived mesenchymal stem cells after increasing passages of cell culture. [J Mol Med] Abstract

Activation of DNA Damage Response Pathways in Human Mesenchymal Stem Cells Exposed to Cisplatin or Gamma-Irradiation
To elucidate the response of undifferentiated human mesenchymal stem cells (hMSCs) to gamma-irradiation and cisplatin, key DNA damage responses were characterised in hMSCs from normal adult donors. [Cell Cycle] Abstract

Adipocytes Differentiated In Vitro from Rat Mesenchymal Stem Cells Lack Essential Free Fatty Acids Compared to Adult Adipocytes
Researchers used gas chromatography-mass spectrometry to identify free fatty acid (FFA) species in bone marrow mesenchymal stem cells-derived adipocytes and compared them to FFAs found in adipocytes derived from adult adipose tissue. [Stem Cells Dev] Abstract

Human Umbilical Cord Blood-Derived Stromal Cells Are Superior to Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Inducing Myeloid Lineage Differentiation In Vitro
Researchers conclude that human umbilical cord blood-derived stromal cells are superior to human umbilical cord blood-derived mesenchymal stem cells in supporting hematopoiesis stem/progenitor cells differentiation into myeloid lineage cells at an early stage in vitro. [Stem Cells Dev] Abstract

Bone Marrow Mesenchymal Stem Cells for Improving Hematopoietic Function: An In Vitro and In Vivo Model – Part II: Effect on Bone Marrow Microenvironment

The aim of this present study was to determine how mesenchymal stem cells could improve bone marrow stroma function after damage, both in vitro and in vivo. [PLoS One]
Abstract

BMP4 Increases Expression of HMGA2 in Mesenchymal Stem Cells
Researchers investigated whether or not the expression of high mobility group protein HMGA2, another protein linked to proliferation and differentiation within the process of adipogenesis, may be influenced by BMP4 signaling in adipose tissue derived stem cells. [Cytokine] Abstract

Effect of Cx43 Gene-Modified Leukemic Bone Marrow Stromal Cells on the Regulation of Jurkat Cell Line In Vitro
In this study, researchers show that following transfection with the Cx43 gene, gap junction intercellular communication function was increased between leukemic bone marrow stromal cells. [Leuk Res] Abstract

In Vitro Study of the Differentiation of Bone Marrow Stromal Cells Into Cardiomyocyte-Like Cells
In this study, researchers aimed to differentiate bone marrow multipotent stromal cells into cardiomyocyte. [Mol Cell Biochem] Abstract

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INDUSTRY NEWS

ViaCord Nabs Rights to TRT’s Platform for Extracting Stem Cells from Cord Tissue
ViaCord® negotiated exclusive U.S. rights to Tissue Regeneration Therapeutics’ (TRT) human umbilical cord perivascular cell technology for extracting mesenchymal stem cells from the tissue surrounding umbilical cord vessels. [Genetic Engineering & Biotechnology News] Press Release

La Jolla Institute Joins Sanford Consortium for Regenerative Medicine
The La Jolla Institute for Allergy & Immunology has become the fifth organization in the prestigious Sanford Consortium for Regenerative Medicine, joining colleagues from the Salk Institute for Biological Studies, The Scripps Research Institute, University of California, San Diego and the Sanford-Burnham Medical Research Institute in the first-of-its-kind multi-institutional stem cell research collaboration. [La Jolla Institute for Allergy & Immunology] Press Release

CCMTR Begins Collaboration with Wake Forest University Institute for Regenerative Medicine
NC State’s Center for Comparative Medicine and Translational Research (CCMTR) and the Institute for Regenerative Medicine at Wake Forest’s Baptist Medical Center are pooling resources in order to find safe and effective ways to use stem cells to regenerate damaged organs in people and pets. [North Carolina (NC) State University College of Veterinary Medicine] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW International Society for Stem Cell Research 10th Annual Meeting
June 13-16, 2012
Yokohama, Japan

Visit our events page to see a complete list of events in the mesenchymal cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

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