Volume 3.47 | Nov 29

Mesenchymal Cell News 3.47, November 29, 2011
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Ionizing Radiation-Induced Expression of INK4a/ARF in Murine Bone Marrow-Derived Stromal Cell Populations Interferes with Bone Marrow Homeostasis
Here, researchers show evidence that exposure to ionizing radiation leads murine stromal bone marrow cells to express senescence markers, namely senescence-associated ß-galactosidase and increased p16INK4a/p19ARF expression. [Blood] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Differential Effects of Dexamethasone on the Chondrogenesis of Mesenchymal Stromal Cells: Influence of Microenvironment, Tissue Origin and Growth Factor
Researchers hypothesize that the influence of dexamethasone on the chondrogenesis of mesenchymal stromal cells depends upon their tissue origin and microenvironment (absence or presence of an extracellular matrix), as well as upon the nature of transforming-growth-factor-β. [Eur Cell Mater] Abstract

Preconditioning by Phosphodiesterase-5 Inhibition Improves Therapeutic Efficacy of Adipose Derived Stem Cells following Myocardial Infarction in Mice
Researchers tested the hypothesis that inhibition of phosphodiesterase-5 with sildenafil or knockdown with a silencing vector in adipose derived stem cells would improve their survival and enhance cardiac function following myocardial implantation in vivo. [Stem Cells] Abstract

Bone Marrow Derived Mesenchymal Stromal Cells Are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo
In this study, in vitro and in vivo migration assays revealed that mesenchymal stromal cells (MSCs) have tropism towards multiple myeloma (MM) cells and CCL25 was identified as a major MM cell-produced chemoattractant for MSCs. [Stem Cells] Abstract

Dedifferentiation-Reprogrammed Mesenchymal Stem Cells with Improved Therapeutic Potential
Here researchers show that, after in vitro induction of neuronal differentiation and dedifferentiation, on withdrawal of extrinsic factors, mesenchymal stem cells derived from bone marrow, which have already committed to neuronal lineage, revert to a primitive cell population retaining stem cell characteristics but exhibiting a reprogrammed phenotype distinct from their original counterparts. [Stem Cells] Abstract

Mesenchymal Stem Cells Enhance Recovery and Repair following Ventilator-Induced Lung Injury in the Rat
This study was undertaken to determine the potential for mesenchymal stem cells to enhance repair after ventilator-induced lung injury and elucidate the mechanisms underlying these effects. [Thorax] Abstract

PPARγ Suppression Inhibits Adipogenesis but Does Not Promote Osteogenesis of Human Mesenchymal Stem Cells
In this study, using human mesenchymal stem cells (hMSCs) as an in vitro model, researchers showed that the two isoforms of proliferator-activated receptor γ (PPARγ), PPARγ1 and PPARγ2, were differentially induced during hMSC adipogenesis, whereas only PPARγ1 was detected during osteogenesis. [Int J Biochem Cell Biol] Abstract

Differential Mesengenic Potential and Expression of Stem Cell Fate Modulators in Mesenchymal Stromal Cells from Human Term Placenta and Bone Marrow
In this study, scientists characterized ex vivo expanded mesenchymal stromal cells (MSCs) from the human amniotic and chorionic membranes of human full term placentas and adult bone marrow. [J Cell Physiol] Abstract

Suppression of Allergic Airway Inflammation in a Mouse Model of Asthma by Exogenous Mesenchymal Stem Cells
Researchers investigated whether exogenous mesenchymal stem cells (MSCs) can relocate to lung tissues in asthmatic mice, analyzed this chemotactic mechanism and evaluated the in vivo immunomodulatory effect of exogenous MSCs in asthma. [Exp Biol Med] Abstract

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INDUSTRY NEWS
UC Davis to Test Stem Cell Therapy to Regenerate Lumbar Discs
Researchers at UC Davis Health System will be part of a nationwide study to examine whether one single injection of adult stem cells directly into diseased lumbar discs can repair and regenerate them, relieve chronic low-back pain and possibly avert spine surgery. [UC Davis Health System] Press Release

Sanford Consortium Opens New “Collaboratory”: First of Its Kind Stem Cell Science Facility Will Harness Intellectual Capital of Five World-Class Research Institutions
The Sanford Consortium for Regenerative Medicine opened a new collaborative research building, formally launching California’s newest facility dedicated to stem cell science. [Sanford Consortium for Regenerative Medicine] Press Release
POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW European School of Haematology – European Haematology Association: Scientific Workshop on Mesenchymal Stem Cells
April 20-22, 2012
Mandelieu, France

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our events page to see a complete list of events in the mesenchymal cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

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