Volume 3.48 | Dec 6

Mesenchymal Cell News 3.48, December 6, 2011
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Culture of Human Mesenchymal Stem Cells at Low Oxygen Tension Improves Growth and Genetic Stability by Activating Glycolysis
Here, researchers demonstrate that culture of human mesenchymal stem cells at lower, physiological oxygen concentrations significantly increases lifespan, limiting oxidative stress, DNA damage, telomere shortening and chromosomal aberrations. [Cell Death Differ] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Pharmacological Modulation of Human Mesenchymal Stem Cell Chondrogenesis by a Chemically Over-Sulphated Polysaccharide of Marine Origin: Potential Application to Cartilage Regenerative Medicine
Here, researchers hypothesize that growth factor-induced differentiation of mesenchymal stem cells can be increased by chemically over-sulphated marine polysaccharides. [Stem Cells] Abstract

Changes in Expression of the Antioxidant Enzyme SOD3 Occur upon Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells In Vitro
The aim of this study was to investigate in vitro if mesenchymal stem cell differentiation down the adipogenic, chondrogenic and osteogenic lineages influences the expression of the antioxidant molecule SOD3. [Stem Cells Dev] Abstract

Temporal Activation of ß-Catenin Signaling in the Chondrogenic Process of Mesenchymal Stem Cells Affects the Phenotype of the Cartilage Generated
This study investigated the temporal effect of transforming growth factor-ß and ß-catenin signaling co-activation during mesenchymal stem cell chondrogenic differentiation and evaluated the influence of these pre-differentiation conditions to subsequent phenotypic development of the cartilage. [Stem Cells Dev] Abstract

Molecular Imaging of Mesenchymal Stem Cell: Mechanistic Insight into Cardiac Repair following Experimental Myocardial Infarction
In this study, researchers found increased angiogenesis and decreased fibrosis were associated with cardiac functional improvement following human mesenchymal stem cell transplantation. [Circ Cardiovasc Imaging] Abstract

Hypoxia Inhibits the Spontaneous Calcification of Bone Marrow-Derived Mesenchymal Stem Cells
In this study, spontaneous calcification of bone marrow-derived mesenchymal stem cells from rats was evaluated in normoxia without osteogenic medium after continuous culture for 21 days. [J Cell Biochem] Abstract

TSH-Induced Gene Expression Involves Regulation of Self-Renewal and Differentiation-Related Genes in Human Bone Marrow-Derived Mesenchymal Stem Cells
In this study, researchers investigated expression and biological consequence of thyroid-stimulating hormone (TSH) receptor interactions in mesenchymal stem cells of cultured human bone marrow. [J Endocrinol] Abstract

Adipose-Derived Stem Cells Promote Lymphangiogenesis in Response to VEGF-C Stimulation or TGF-ß1 Inhibition
The purpose of this study was to determine whether adipose-derived stem cells can be used in lymphatic tissue-engineering by altering the balance between pro- and anti-lymphangiogenic cytokines. [Future Oncol] Abstract

Simvastatin Inhibits Sphingosylphosphorylcholine-Induced Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle Cells
In the present study, researchers examined the effects of simvastatin on the sphingosylphosphorylcholine-induced α-smooth muscle actin expression and Smad2 phosphorylation in human adipose tissue-derived mesenchymal stem cells. [Exp Mol Med] Abstract

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INDUSTRY NEWS

Karolinska Institutet and Mayo Clinic Strengthen Their Cooperation
The scope of Karolinska Institutet’s cooperation with one of the world’s leading health organizations, Mayo Clinic, is now being extended through a formal contract. [Karolinska Institutet] Press Release

Sanford Consortium Opening Celebrates Stem Cell Research on the Mesa
The Scripps Research Institute joined four other institutions on San Diego’s Torrey Pines mesa in a ceremony celebrating the opening of The Sanford Consortium for Regenerative Medicine. [The Scripps Research Institute] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Gordon Research Conference: Craniofacial Morphogenesis & Tissue Regeneration
March 18-23, 2012
Ventura, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)


Business Analyst – Product Management (STEMSOFT Software)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

Assistant Professor – Regenerative Medicine/Stem Cell Biology (University of Pennyslvania)

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