Volume 4.00 | Jan 3

Mesenchymal Cell News 4.00, January 3, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells
Here, adipose-derived stem cells are shown to not just simply reflect the qualitative stiffness sensitivity of bone marrow-derived stem cells (BMSCs) but to exceed BMSC myogenic capacity, expressing the appropriate temporal sequence of muscle transcriptional regulators on muscle-mimicking extracellular matrix in a tension and focal adhesion-dependent manner. [Biomaterials] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Effects of Micropitted/Nanotubular Titania Topographies on Bone Mesenchymal Stem Cell Osteogenic Differentiation
The effects of micropitted/nanotubular titania topographies on bone mesenchymal stem cell osteogenic differentiation was studied systematically by various microscopic and biological characterization techniques. [Biomaterials] Abstract

Comparative Analysis of Paracrine Factor Expression in Human Adult Mesenchymal Stem Cells Derived from Bone Marrow, Adipose and Dermal Tissue
Scientists evaluated paracrine factor expression patterns in mesenchymal stem cells isolated from adipose tissue, bone marrow and dermal tissues. [Stem Cells Dev] Abstract

Nanomechanics of Human Adipose Derived Stem Cells: Small GTPases Impact Chondrogenic Differentiation
The aim of this study was to investigate the impact of small GTPases on TGF-ß1 mediated chondrogenic differentiation of human adipose derived stem cells and compare it with BMP-2 induced hypertrophy, by assessing effects on intracellular and extracellular matrix. [Tissue Eng Part A] Abstract

Evaluation of Bone Marrow-Derived MSC after Cryopreservation and Hypothermic Storage in Clinically Safe Medium
Efficacy of cryopreservation of human bone marrow-derived mesenchymal stem cells (MSC) in clinically safe, animal product free medium containing 2, 5, and 10% DMSO was evaluated by measuring cell recovery, viability, apoptosis, proliferation rate, expression of a broad panel of MSC markers and osteogenic differentiation. [Tissue Eng Part C Methods] Abstract

Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy
In this study, researchers hypothesized whether freshly isolated human bone marrow mesenchymal stem cells and mature murine stromal cells primed in vitro with anti-cancer drugs and then localized near cancer cells, could inhibit proliferation. [PLoS One] Abstract

LPS-Pretreated Bone Marrow Stem Cells as Potential Treatment for Myocardial Infarction
The purpose of this study was to investigate the distribution, the number, and the survival time of rat bone marrow mesenchymal stem cells, implanted in rats with myocardial infarction, that were initially pretreated with low dose of LPS. [Front Biosci] Abstract

Human Adipose Tissue-Derived Mesenchymal Stem Cells Protect Kidneys from Cisplatin Nephrotoxicity in Rats
Researchers tested whether human adipose tissue-derived mesenchymal stem cells can affect multiple target sites and protect against cisplatin-induced kidney damage. [Am J Physiol Renal Physiol] Abstract

Rosuvastatin Elicits Kinase Insert Domain Receptor-Dependent Vasculogenic Response of Human Placental Stem Cells through PI3K/AKT Pathway
Researchers assessed whether rosuvastatin may drive a gene program of vascular commitment and the secretion of trophic mediators with antiapoptotic, angiogenic and antifibrotic activities in human mesenchymal stem cells from full-term placentas. [Pharmacol Res] Abstract

Spontaneous Transformation of Cynomolgus Mesenchymal Stem Cells In Vitro: Further Confirmation by Short Tandem Repeat Analysis
In this study researchers provided evidence, using short tandem repeat analysis, that transformed mesenchymal stem cells are derived from cynomolgus mesenchymal stem cells. [Exp Cell Res] Abstract

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TiGenix Obtains €2.9 Million FP7 Grant to Fund Development of Cx611 in Rheumatoid Arthritis
TiGenix announced it has obtained a substantial grant from the European Seventh Framework Programme (FP7) to support the development of its Cx611 program of allogeneic expanded adipose derived stem cells for the treatment of rheumatoid arthritis. [TiGenix] Press Release

PerkinElmer’s ViaCord® Cord Blood Banking Business Collaborates with Miracle Babies to Improve Collection of Stem Cells from Premature Births for Potential Therapeutic Use
PerkinElmer, Inc. announced that its family cord blood banking business, ViaCord®, entered into a collaborative study with Miracle Babies. This collaboration will study and promote the discovery of methods for optimizing collection of umbilical cord blood and cord tissue stem cells following premature births, providing a valuable resource for potential therapeutic use. [PerkinElmer, Inc.] Press Release

Osiris Therapeutics Provides Update on Groundbreaking Stem Cell Trial for Type 1 Diabetes
Osiris Therapeutics, Inc. provided an update on its Phase II trial evaluating Prochymal, a formulation of adult mesenchymal stem cells, in patients with newly diagnosed type 1 diabetes. [Osiris Therapeutics, Inc.]
Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 3rd International Conference on Stem Cells and Cancer 2012: Proliferation, Differentiation and Apoptosis
October 27-30, 2012
Pune, India

Visit our events page to see a complete list of events in the mesenchymal cell community.

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Assistant Professor – Regenerative Medicine/Stem Cell Biology (University of Pennsylvania)

Postdoctoral Positions – Stem Cell Biology (Columbia University)

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