Volume 4.02 | Jan 17

Mesenchymal Cell News 4.02, January 17, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Osteogenic Differentiation of Mesenchymal Stem Cells Is Regulated by Osteocyte and Osteoblast Cells in a Simplified Bone Niche
In this study researchers delineate the role of biochemical signaling from osteocytes and osteoblasts, using conditioned media and co-culture experiments, to understand how they can direct osteogenic differentiation of mesenchymal stem cells. [Eur Cell Mater] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Bone Marrow- and Subcutaneous Adipose Tissue-Derived Mesenchymal Stem Cells: Differences and Similarities
Researchers data demonstrate that specific properties of mesenchymal stem cells (MSCs) from different sources should be always taken into account, when developing and optimizing the specific protocols for MSC expansion and evaluation for each particular clinical application. [Cell Cycle] Abstract

Proliferation as a Requirement for In Vitro Chondrogenesis of Human Mesenchymal Stem Cells
During embryonic cartilage development proliferation and differentiation are tightly linked with a transient cell cycle arrest observed during determination and before main extracellular matrix production.The aim of this study was to address whether these steps are imitated during in vitro differentiation of mesenchymal stem cells and are crucial for a proper chondrogenesis. [Stem Cells Dev] Abstract

Distinct Differentiation Potential of “MSC” Derived from Cord Blood and Umbilical Cord: Are Cord-Derived Cells True Mesenchymal Stromal Cells?
In order to determine whether cells isolated from human umbilical cord fulfill the criteria defined for mesenchymal stromal cells (MSC), the immunophenotype and differentiation potential including gene expression analysis of the most relevant lineage-specific markers were analyzed in the presented report in combination with the HOX-gene expression. [Stem Cells Dev] Abstract

Mesenchymal Stem Cells Induce Functionally Active T Regulatory Lymphocytes in a Paracrine Fashion and Ameliorate Experimental Autoimmune Uveitis
Here researchers studied the effect of mesenchymal stem/progenitor cells (MSCs) on induction of  CD4+CD25+FoxP3+ T lymphocytes with regulatory functions (Treg) and on development of autoimmunity, and examined the possibility that MSC-mediated Treg induction could be due to the secretion of soluble factors. [Invest Ophthalmol Vis Sci] Abstract

Transplantation of Mesenchymal Stem Cells Promotes the Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury
The present study was designed to investigate the effects of mesenchymal stem cell transplantation with a special focus on their effect on macrophage activation after spinal cord injury. [J Neurotrauma] Abstract

Human Umbilical Cord Wharton’s Jelly Mesenchymal Stem Cells Do Not Transform to Tumor-Associated Fibroblasts in the Presence of Breast and Ovarian Cancer Cells Unlike Bone Marrow Mesenchymal Stem Cells
Researchers confirmed that human Wharton’s jelly stem cells do not transform to the tumor-associated fibroblast phenotype and may therefore not be associated with enhanced growth of solid tumors making them a safe mesenchymal stem cell for cell based therapies. [J Cell Biochem] Abstract

Mesenchymal Stem Cell Transplantation to Promote Bone Healing
The objective of this current study was to determine if transplantation of mesenchymal stromal cells from a healthy, young donor mouse into an osteopenic recipient mouse could enhance osseointegration of a femoral implant. [J Orthop Res] Abstract

Extracellular Signal-Regulated Kinase (ERK) Dictates Osteogenic and/or Chondrogenic Lineage Commitment of Mesenchymal Stem Cells Under Dynamic Compression
Here researchers explore the role of the ERK1/2 pathway on the mechanical induction of chondrogenesis of bone marrow mesenchymal stem cells. [Biochem Biophys Res Commun] Abstract

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INDUSTRY NEWS

BrainStorm Sees Positive Data in ALS Stem Cell Trial
Data from the first amyotrophic lateral sclerosis (ALS) patients in a clinical trial treated with BrainStorm Cell Therapeutics adult stem cell therapy did not show significant side effects and the treatment has so far proven to be safe. [Reuters] Press Release

CIFAR Announces Dr. Alan Bernstein, O.C. As New President and CEO
On behalf of the Board of the Canadian Institute for Advanced Research (CIFAR), David Dodge announced the appointment of Dr. Alan Bernstein as the Institute’s new President and CEO. [Canadian Institute for Advanced Research] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Keystone Symposia on Molecular and Cellular Biology: Pulmonary Vascular Disease and Right Ventricular Dysfunction – Current Concepts and Future Therapies
September 10-15, 2012
Monterey, United States

NEW OMICS Group: 2nd World Congress on Cell Science & Stem Cell Research
San Antonio, United States
November 12-14, 2012

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)


Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Positions – Stem Cell Biology (Columbia University)

PhD Position – Mechanobiology (University College Dublin)


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