Volume 4.07 | Feb 21

Mesenchymal Cell News 4.07, February 21, 2012
     In this issue: Publications Science News Industry News | Policy News | Events | Jobs 
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A Novel Function for the Hematopoietic Supportive Murine Bone Marrow MS-5 Mesenchymal Stromal Cell Line in Promoting Human Vasculogenesis and Angiogenesis
Researchers suggest that the clonal nestin+ MS-5 murine bone marrow stromal cell line not only promotes human hematopoiesis but also induces human vasculogenesis, with CXCL12 playing important roles in both processes. [Br J Haematol] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Epidermal Growth Factor Receptor Ligands Drive Multipotential Stromal Cells to Produce Multiple Growth Factors and Cytokines via Early Growth Response-1
The strong paracrine capability of various growth factors and cytokines is a key mechanism of adult bone marrow multipotential stromal cell/mesenchymal stem cell (MSC)-mediated wound healing and tissue regeneration, and the goal of this study was to understand the underlying mechanism that supports the strong paracrine machineries in MSCs. [Stem Cells Dev] Abstract

Human Adipose-Derived Mesenchymal Stem Cells Systemically Injected Promote Peripheral Nerve Regeneration in the Mouse Model of Sciatic Crush
Researchers show that systemically injected adipose-derived mesenchymal stem cells have a clear therapeutic potential in an acute model of axonal damage. [Tissue Eng Part A] Abstract

Autologous Adipocyte Derived Stem Cells Favor Healing in a Minipig Model of Cutaneous Radiation Syndrome
Here researchers examined for the first time in a large animal model the therapeutic potential of autologous adipose tissue-derived stroma cells. [PLoS One] Abstract

Analysis of Circulating Mesenchymal Progenitor Cells in Arterial and Venous Blood after Fracture
In this study, researchers investigated the number of mesenchymal progenitor cells in arterial blood, venous blood and bone marrow after fracture in rabbits via the colony-forming unit-fibroblasts assay, and clarified the time-course change. [J Tissue Eng Regen Med] Abstract

Neovascular Potential of Adipose-Derived Stromal Cells (ASCs) from Diabetic Patients
Researchers explored the vascular biology of ASCs from diabetic patients and applied these cells to a murine ischemic flap model to assess the comparative angiogenic potentials between normal and diabetic human ASCs. [Wound Repair Regen] Abstract

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Increases Engraftment and Inhibits Lineage Commitment of Mesenchymal Stem Cells (MSCs)
In the present study, researchers hypothesized that pyrvinium would enhance MSC self-renewal to improve the clinical efficacy of MSC therapy. [Wound Repair Regen] Abstract

Differentiation of Umbilical Cord Mesenchymal Stem Cells into Steroidogenic Cells in Comparison to Bone Marrow Mesenchymal Stem Cells
In this study, umbilical cord Wharton’s jelly-derived mesenchymal stem cells (MSCs) were induced to become steroidogenic cells and compared to bone marrow-derived MSCs. [Cell Prolif] Abstract

Activated T-Cells and Pro-Inflammatory Cytokines Differentially Regulate Prostaglandin E2 Secretion by Mesenchymal Stem Cells
Here researchers investigated prostaglandin E2 production of murine bone marrow- and adipose tissue-derived mesenchymal stem or stromal cells stimulated with pro-inflammatory cytokines tumor necrosis factor-α and interferon-γ, or co-cultured with ConA-induced T-cell blasts. [Biochem Biophys Res Commun] Abstract

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ARMC Stem Cell Clinical Trial Reveals Outstanding Results for Chronic Wounds
Physicians recently completed a clinical trial involving autologous stem cell therapy that showed outstanding success in the treatment of chronic wounds and pressure ulcers. [Arrowhead Regional Medical Center (ARMC)] Press Release


Harvard Scientist to Lead USC Center in Stem Cell Research
Biologist Andrew P. McMahon will leave Harvard University to join the Keck School of Medicine of University of Southern California (USC) as a Provost Professor and the inaugural holder of the W. M. Keck Professorship of Stem Cell Biology and Regenerative Medicine. [University of Southern California]
Press Release

Queen’s Soft Tissue Replacement Technology Gets a Funding Boost
A new process for transforming discarded human fat into a soft-tissue substitute for use in reconstructive surgery is laying the groundwork for creating an Ontario-based regenerative medicine initiative focused on developing products for reconstructive and cosmetic surgery. [Queen’s University] Press Release

NSF Tops Research Agencies With a $340-Million Boost
President Barack Obama proposed a 4.8% increase in funding for the National Science Foundation (NSF) as part of his $3.8-trillion budget request for 2013. The $340-million boost is the largest absolute increase in spending for any federal research agency. [National Science Foundation, United States] Press Release

Stemedica Granted US Patent for Cellular Scaffold
Stemedica Cell Technologies, Inc. announced that the Company has been issued United States (US) Patent #8,105,380 by the US Patent and Trademark Office. This broad-based patent covers the combination of scaffolds with stem cells derived from ectodermal and mesenchymal tissue. [Stemedica Cell Technologies, Inc.] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW European Molecular Biology Laboratory (EMBL) Conference: Stem Cells in Cancer and Regenerative Medicine
August 29-September 1, 2012
Heidelberg, Germany

NEW 3rd International Congress on Responsible Stem Cell Research (RSCR)
Vatican City, Italy
April 25-28, 2012

Visit our events page to see a complete list of events in the mesenchymal cell community.


Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientific Marketing Communications Specialist (STEMCELL Technologies, Inc.)

Research Technologist (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Research Associates/Scientist/Senior Scientist – Stem Cell Research (Advanced Cell Technology) 

PhD Student – Immunotherapy Using Mesenchymal Stem Cells (Charles University)

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Postdoctoral Fellow (University of Rochester Medical Center)

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