Volume 4.13 | Apr 3

Mesenchymal Cell News 4.13, April 3, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
Therapeutic Effects of Intrabone and Systemic Mesenchymal Stem Cell Cytotherapy on Myeloma Bone Disease and Tumor Growth
Scientists evaluated the effects of intrabone and systemic injections of mesenchymal stem cells (MSCs) on multiple myeloma bone disease, tumor growth, and tumor regrowth in the SCID-rab model and to shed light on the exact localization of systemically injected MSCs. [J Bone Miner Res] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Influence of Decellularized Matrix Derived from Human Mesenchymal Stem Cells on Their Proliferation, Migration and Multi-Lineage Differentiation Potential
Investigators aimed to characterize the biological nature and specificity of the influence of the mesenchymal stem cell (MSC) extracellular matrix on MSCs. [Biomaterials] Abstract

Spherical Bullet Formation via E-cadherin Promotes Therapeutic Potency of Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood for Myocardial Infarction
Researchers developed a spheroid three dimensional bullet as a delivery method for human umbilical cord blood-derived mesenchymal stem cells through the maintenance of cell-cell interactions without additional xenofactors, cytokines, or matrix. [Mol Ther] Abstract

Systemic Administration of Autologous Adipose-Derived Mesenchymal Stem Cells Alleviates Hepatic Ischemia-Reperfusion Injury in Rats
Researchers investigated the therapeutic role of adipose tissue-derived mesenchymal stem cells in hepatic ischemia-reperfusion injury and the underlying mechanisms. [Crit Care Med] Abstract

Tailored Integrin-Extracellular Matrix Interactions to Direct Human Mesenchymal Stem Cell Differentiation
Researchers confirm that integrin-extracellular matrix contacts change throughout human bone marrow-derived mesenchymal stem cell (hMSC) differentiation and show that surfaces presenting defined peptide sequences can be used to target specific integrins and ultimately influence hMSC differentiation. [Stem Cells Dev]
Abstract

Vascular Morphogenesis of Adipose-Derived Stem Cells Is Mediated by Heterotypic Cell-Cell Interactions
Scientists report the novel finding that adipose-derived stromal/stem cells grown in monolayer in the presence of angiogenic cues are capable of self-assembling into complex, three-dimensional vascular structures. [Tissue Eng Part A] Abstract

Engineering of Bone Using Porous Calcium Phosphate Cement and Bone Marrow Stromal Cells for Maxillary Sinus Augmentation with Simultaneous Implant Placement in Goats
The aim of this study was to explore the effects of maxillary sinus floor elevation and simultaneous dental implantation with a tissue engineered bone complex of calcium phosphate cement scaffolds combined with bone marrow stromal cells. [Tissue Eng Part A] Abstract

Human Chorionic Villus Mesenchymal Stromal Cells Reveal Strong Endothelial Conversion Properties
Researchers demonstrated that, despite of fetal origin, chorionic villi mesenchymal stromal cells (StC) exhibit restricted plasticity, distinct from that of bone marrow StC and predominantly directed toward the endothelial lineage. [Differentiation] Abstract

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INDUSTRY NEWS

AlloCure Raises $25 Million Series B Venture Financing – New Funding to Support Phase II Trial of Novel Therapy for Acute Kidney Injury
AlloCure, Inc. announced the closing of a $25 million Series B venture financing. AlloCure is developing AC607, an allogeneic mesenchymal stem cell therapy, for acute kidney injury. [AlloCure, Inc.] Press Release


$63 Million NIH Grant Helps UF, National Consortium Explore Cell Regeneration Therapies for Heart Disease
University of Florida (UF) researchers and colleagues at six other institutions have received a $63 million, seven-year grant from the NIH National Heart, Lung and Blood Institute to develop heart disease therapies that use a patient’s own bone marrow and heart cells to generate new healthy heart cells and restore function. [University of Florida] Press Release


Bioquark Inc., Organ Regeneration and Tissue Repair Company, Retains JSBarkats PLLC for Public Offering and PIPE Financing
Bioquark Inc. announced that it has retained the services of JSBarkats PLLC to represent Bioquark in all aspects of the company’s SEC compliance and securities legal work, as well as help with structuring future financing for the company. [PR Newswire] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 6th Mesenchymal Stem Cell Conference
June 15, 2012
Southampton, United Kingdom


Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)


Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)


Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 


Postdoctoral Fellow (Erasmus MC)

Research Associate(s) (Imperial College London) 

PhD Student (University of Liège) 


Postdoctoral Position (GENyO)

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